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A multicenter surveillance of antimicrobial resistance in Serratia marcescens in Taiwan
BACKGROUND: Serratia marcescens is an important nosocomial pathogen and the characteristic property of resistance conferred by extended-spectrum beta-lactamase or a novel AmpC cephalosporinase was not unusual in Taiwan. This study investigated the trends in antimicrobial resistance in S. marcescens...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Published by Elsevier Taiwan LLC.
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7105062/ https://www.ncbi.nlm.nih.gov/pubmed/23751769 http://dx.doi.org/10.1016/j.jmii.2013.04.003 |
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author | Liou, Bo-Huang Duh, Ruay-Wang Lin, Yi-Tsung Yang Lauderdale, Tsai-Ling Fung, Chang-Phone |
author_facet | Liou, Bo-Huang Duh, Ruay-Wang Lin, Yi-Tsung Yang Lauderdale, Tsai-Ling Fung, Chang-Phone |
author_sort | Liou, Bo-Huang |
collection | PubMed |
description | BACKGROUND: Serratia marcescens is an important nosocomial pathogen and the characteristic property of resistance conferred by extended-spectrum beta-lactamase or a novel AmpC cephalosporinase was not unusual in Taiwan. This study investigated the trends in antimicrobial resistance in S. marcescens from a nationwide surveillance in Taiwan. MATERIALS AND METHODS: S. marcescens isolates were collected biennially between 2002 and 2010 from medical centers and regional hospitals throughout Taiwan, as part of the Taiwan Surveillance of Antimicrobial Resistance program. Minimal inhibitory concentrations were determined by the Clinical and Laboratory Standards Institute reference broth microdilution method. RESULTS: A total of 403 nonduplicate S. marcescens isolates were collected, mostly from respiratory samples (157, 39.0%), followed by the urinary tract samples (90, 22.3%). Overall, 99.3% isolates were susceptible to imipenem, 93.8% to ceftazidime, 89.2% to minocycline, 87.8% to amikacin, 86.8% to cefepime, 82.9% to aztreonam, 73.2% to ceftriaxone, 72.7% to levofloxacin, 63.8% to ciprofloxacin, 60.8% to trimethoprim/sulfamethoxazole (TMP/SMX), and 59.6% to gentamicin. A significantly increased susceptibility rate after 2004 was observed for the following antibiotics: amikacin (73.8% vs. 97.1%), gentamicin (40.0% vs. 72.4%), ciprofloxacin (53.8% vs. 70.4%), ceftriaxone (53.8% vs. 86.0%), cefepime (74.4% vs. 95.1%), aztreonam (72.5% vs. 89.7%), and TMP/SMX (41.3% vs. 73.7%). CONCLUSION: In this 8-year study, the susceptibility of S. marcescens to ceftazidime and imipenem remained consistently high in Taiwan. S. marcescens isolates demonstrated relatively higher resistance to ciprofloxacin and levofloxacin, and therefore continued surveillance of antimicrobial resistance, especially for fluoroquinolone, is warranted. |
format | Online Article Text |
id | pubmed-7105062 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Published by Elsevier Taiwan LLC. |
record_format | MEDLINE/PubMed |
spelling | pubmed-71050622020-03-31 A multicenter surveillance of antimicrobial resistance in Serratia marcescens in Taiwan Liou, Bo-Huang Duh, Ruay-Wang Lin, Yi-Tsung Yang Lauderdale, Tsai-Ling Fung, Chang-Phone J Microbiol Immunol Infect Article BACKGROUND: Serratia marcescens is an important nosocomial pathogen and the characteristic property of resistance conferred by extended-spectrum beta-lactamase or a novel AmpC cephalosporinase was not unusual in Taiwan. This study investigated the trends in antimicrobial resistance in S. marcescens from a nationwide surveillance in Taiwan. MATERIALS AND METHODS: S. marcescens isolates were collected biennially between 2002 and 2010 from medical centers and regional hospitals throughout Taiwan, as part of the Taiwan Surveillance of Antimicrobial Resistance program. Minimal inhibitory concentrations were determined by the Clinical and Laboratory Standards Institute reference broth microdilution method. RESULTS: A total of 403 nonduplicate S. marcescens isolates were collected, mostly from respiratory samples (157, 39.0%), followed by the urinary tract samples (90, 22.3%). Overall, 99.3% isolates were susceptible to imipenem, 93.8% to ceftazidime, 89.2% to minocycline, 87.8% to amikacin, 86.8% to cefepime, 82.9% to aztreonam, 73.2% to ceftriaxone, 72.7% to levofloxacin, 63.8% to ciprofloxacin, 60.8% to trimethoprim/sulfamethoxazole (TMP/SMX), and 59.6% to gentamicin. A significantly increased susceptibility rate after 2004 was observed for the following antibiotics: amikacin (73.8% vs. 97.1%), gentamicin (40.0% vs. 72.4%), ciprofloxacin (53.8% vs. 70.4%), ceftriaxone (53.8% vs. 86.0%), cefepime (74.4% vs. 95.1%), aztreonam (72.5% vs. 89.7%), and TMP/SMX (41.3% vs. 73.7%). CONCLUSION: In this 8-year study, the susceptibility of S. marcescens to ceftazidime and imipenem remained consistently high in Taiwan. S. marcescens isolates demonstrated relatively higher resistance to ciprofloxacin and levofloxacin, and therefore continued surveillance of antimicrobial resistance, especially for fluoroquinolone, is warranted. Published by Elsevier Taiwan LLC. 2014-10 2013-06-14 /pmc/articles/PMC7105062/ /pubmed/23751769 http://dx.doi.org/10.1016/j.jmii.2013.04.003 Text en Copyright © 2013 Published by Elsevier Taiwan LLC. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Liou, Bo-Huang Duh, Ruay-Wang Lin, Yi-Tsung Yang Lauderdale, Tsai-Ling Fung, Chang-Phone A multicenter surveillance of antimicrobial resistance in Serratia marcescens in Taiwan |
title | A multicenter surveillance of antimicrobial resistance in Serratia marcescens in Taiwan |
title_full | A multicenter surveillance of antimicrobial resistance in Serratia marcescens in Taiwan |
title_fullStr | A multicenter surveillance of antimicrobial resistance in Serratia marcescens in Taiwan |
title_full_unstemmed | A multicenter surveillance of antimicrobial resistance in Serratia marcescens in Taiwan |
title_short | A multicenter surveillance of antimicrobial resistance in Serratia marcescens in Taiwan |
title_sort | multicenter surveillance of antimicrobial resistance in serratia marcescens in taiwan |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7105062/ https://www.ncbi.nlm.nih.gov/pubmed/23751769 http://dx.doi.org/10.1016/j.jmii.2013.04.003 |
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