Combination immunotherapy with anti-PD-L1 antibody and depletion of regulatory T cells during acute viral infections results in improved virus control but lethal immunopathology

Combination immunotherapy (CIT) is currently applied as a treatment for different cancers and is proposed as a cure strategy for chronic viral infections. Whether such therapies are efficient during an acute infection remains elusive. To address this, inhibitory receptors were blocked and regulatory...

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Detalles Bibliográficos
Autores principales: David, Paul, Drabczyk-Pluta, Malgorzata, Pastille, Eva, Knuschke, Torben, Werner, Tanja, Honke, Nadine, Megger, Dominik A., Akhmetzyanova, Ilseyar, Shaabani, Namir, Eyking-Singer, Annette, Cario, Elke, Kershaw, Olivia, Gruber, Achim D., Tenbusch, Matthias, Dietze, Kirsten K., Trilling, Mirko, Liu, Jia, Schadendorf, Dirk, Streeck, Hendrik, Lang, Karl S., Xie, Youhua, Zimmer, Lisa, Sitek, Barbara, Paschen, Annette, Westendorf, Astrid M., Dittmer, Ulf, Zelinskyy, Gennadiy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7105110/
https://www.ncbi.nlm.nih.gov/pubmed/32226027
http://dx.doi.org/10.1371/journal.ppat.1008340

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