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Risk of biliary tract disease in living liver donors: A population-based cohort study

BACKGROUND & AIMS: Whether living liver donors have a higher risk of biliary tract disease compared with non-donors remains unknown. METHODS: Data were collected from the Taiwan Longitudinal Health Insurance Database for the 2003–2011 period. The study cohort comprised 1,446 patients aged ≥ 18 y...

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Autores principales: Lin, Shih-Yi, Lin, Cheng-Li, Hsu, Wu-Huei, Wang, I-Kuan, Lin, Cheng-Chieh, Jeng, Long-Bing, Kao, Chia-Hung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7105125/
https://www.ncbi.nlm.nih.gov/pubmed/32226025
http://dx.doi.org/10.1371/journal.pone.0230840
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author Lin, Shih-Yi
Lin, Cheng-Li
Hsu, Wu-Huei
Wang, I-Kuan
Lin, Cheng-Chieh
Jeng, Long-Bing
Kao, Chia-Hung
author_facet Lin, Shih-Yi
Lin, Cheng-Li
Hsu, Wu-Huei
Wang, I-Kuan
Lin, Cheng-Chieh
Jeng, Long-Bing
Kao, Chia-Hung
author_sort Lin, Shih-Yi
collection PubMed
description BACKGROUND & AIMS: Whether living liver donors have a higher risk of biliary tract disease compared with non-donors remains unknown. METHODS: Data were collected from the Taiwan Longitudinal Health Insurance Database for the 2003–2011 period. The study cohort comprised 1,446 patients aged ≥ 18 years who had served as living liver donors. The primary outcome was the incidence of biliary tract disease. Cox proportional hazards modeling was used to determine the hazard ratios. RESULTS: The incidence density rate of biliary tract disease was 13.9-fold higher in the liver donor (LD) cohort than in the non-LD cohort (10.2 vs. 0.71 per 1,000 person-years), with an adjusted hazard ratio (HR) of 14.2 (95% confidence interval [CI] = 7.73–26.1). Stratified by comorbidity, the relative risk of biliary tract disease was higher in the LD cohort than in the non-LD cohort for both patients with or without comorbidity. The incidence density rate of biliary tract disease was significantly higher in the first 3 years (13.5 per 1,000 person-years in the LD cohort). The highest adjusted HR of biliary tract disease for LD patients compared with the non-LD cohort was 22.4 (95% CI = 10.8–46.1) in the follow-up ≤ 3 years. CONCLUSION: Living liver donors had a higher risk of biliary tract disease compared with non-donors.
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spelling pubmed-71051252020-04-03 Risk of biliary tract disease in living liver donors: A population-based cohort study Lin, Shih-Yi Lin, Cheng-Li Hsu, Wu-Huei Wang, I-Kuan Lin, Cheng-Chieh Jeng, Long-Bing Kao, Chia-Hung PLoS One Research Article BACKGROUND & AIMS: Whether living liver donors have a higher risk of biliary tract disease compared with non-donors remains unknown. METHODS: Data were collected from the Taiwan Longitudinal Health Insurance Database for the 2003–2011 period. The study cohort comprised 1,446 patients aged ≥ 18 years who had served as living liver donors. The primary outcome was the incidence of biliary tract disease. Cox proportional hazards modeling was used to determine the hazard ratios. RESULTS: The incidence density rate of biliary tract disease was 13.9-fold higher in the liver donor (LD) cohort than in the non-LD cohort (10.2 vs. 0.71 per 1,000 person-years), with an adjusted hazard ratio (HR) of 14.2 (95% confidence interval [CI] = 7.73–26.1). Stratified by comorbidity, the relative risk of biliary tract disease was higher in the LD cohort than in the non-LD cohort for both patients with or without comorbidity. The incidence density rate of biliary tract disease was significantly higher in the first 3 years (13.5 per 1,000 person-years in the LD cohort). The highest adjusted HR of biliary tract disease for LD patients compared with the non-LD cohort was 22.4 (95% CI = 10.8–46.1) in the follow-up ≤ 3 years. CONCLUSION: Living liver donors had a higher risk of biliary tract disease compared with non-donors. Public Library of Science 2020-03-30 /pmc/articles/PMC7105125/ /pubmed/32226025 http://dx.doi.org/10.1371/journal.pone.0230840 Text en © 2020 Lin et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Lin, Shih-Yi
Lin, Cheng-Li
Hsu, Wu-Huei
Wang, I-Kuan
Lin, Cheng-Chieh
Jeng, Long-Bing
Kao, Chia-Hung
Risk of biliary tract disease in living liver donors: A population-based cohort study
title Risk of biliary tract disease in living liver donors: A population-based cohort study
title_full Risk of biliary tract disease in living liver donors: A population-based cohort study
title_fullStr Risk of biliary tract disease in living liver donors: A population-based cohort study
title_full_unstemmed Risk of biliary tract disease in living liver donors: A population-based cohort study
title_short Risk of biliary tract disease in living liver donors: A population-based cohort study
title_sort risk of biliary tract disease in living liver donors: a population-based cohort study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7105125/
https://www.ncbi.nlm.nih.gov/pubmed/32226025
http://dx.doi.org/10.1371/journal.pone.0230840
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