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Pediatric Asthma and Viral Infection()
Respiratory viral infections, particularly respiratory syncytial virus (RSV) and rhinovirus, are the most importance risk factors for the onset of wheezing in infants and small children. Bronchiolitis is the most common acute respiratory infection in children under 1 year of age, and the most common...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Published by Elsevier España, S.L.U. on behalf of SEPAR.
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7105201/ https://www.ncbi.nlm.nih.gov/pubmed/26766408 http://dx.doi.org/10.1016/j.arbr.2016.03.010 |
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author | Luz Garcia-Garcia, M. Calvo Rey, Cristina del Rosal Rabes, Teresa |
author_facet | Luz Garcia-Garcia, M. Calvo Rey, Cristina del Rosal Rabes, Teresa |
author_sort | Luz Garcia-Garcia, M. |
collection | PubMed |
description | Respiratory viral infections, particularly respiratory syncytial virus (RSV) and rhinovirus, are the most importance risk factors for the onset of wheezing in infants and small children. Bronchiolitis is the most common acute respiratory infection in children under 1 year of age, and the most common cause of hospitalization in this age group. RSV accounts for approximately 70% of all these cases, followed by rhinovirus, adenovirus, metapneumovirus and bocavirus. The association between bronchiolitis caused by RSV and the development of recurrent wheezing and/or asthma was first described more than 40 years ago, but it is still unclear whether bronchiolitis causes chronic respiratory symptoms, or if it is a marker for children with a genetic predisposition for developing asthma in the medium or long term. In any case, sufficient evidence is available to corroborate the existence of this association, which is particularly strong when the causative agent of bronchiolitis is rhinovirus. The pathogenic role of respiratory viruses as triggers for exacerbations in asthmatic patients has not been fully characterized. However, it is clear that respiratory viruses, and in particular rhinovirus, are the most common causes of exacerbation in children, and some type of respiratory virus has been identified in over 90% of children hospitalized for an episode of wheezing. Changes in the immune response to viral infections in genetically predisposed individuals are very likely to be the main factors involved in the association between viral infection and asthma. |
format | Online Article Text |
id | pubmed-7105201 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Published by Elsevier España, S.L.U. on behalf of SEPAR. |
record_format | MEDLINE/PubMed |
spelling | pubmed-71052012020-03-31 Pediatric Asthma and Viral Infection() Luz Garcia-Garcia, M. Calvo Rey, Cristina del Rosal Rabes, Teresa Arch Bronconeumol Article Respiratory viral infections, particularly respiratory syncytial virus (RSV) and rhinovirus, are the most importance risk factors for the onset of wheezing in infants and small children. Bronchiolitis is the most common acute respiratory infection in children under 1 year of age, and the most common cause of hospitalization in this age group. RSV accounts for approximately 70% of all these cases, followed by rhinovirus, adenovirus, metapneumovirus and bocavirus. The association between bronchiolitis caused by RSV and the development of recurrent wheezing and/or asthma was first described more than 40 years ago, but it is still unclear whether bronchiolitis causes chronic respiratory symptoms, or if it is a marker for children with a genetic predisposition for developing asthma in the medium or long term. In any case, sufficient evidence is available to corroborate the existence of this association, which is particularly strong when the causative agent of bronchiolitis is rhinovirus. The pathogenic role of respiratory viruses as triggers for exacerbations in asthmatic patients has not been fully characterized. However, it is clear that respiratory viruses, and in particular rhinovirus, are the most common causes of exacerbation in children, and some type of respiratory virus has been identified in over 90% of children hospitalized for an episode of wheezing. Changes in the immune response to viral infections in genetically predisposed individuals are very likely to be the main factors involved in the association between viral infection and asthma. Published by Elsevier España, S.L.U. on behalf of SEPAR. 2016-05 2016-03-26 /pmc/articles/PMC7105201/ /pubmed/26766408 http://dx.doi.org/10.1016/j.arbr.2016.03.010 Text en © 2016 Published by Elsevier España, S.L.U. on behalf of SEPAR. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Luz Garcia-Garcia, M. Calvo Rey, Cristina del Rosal Rabes, Teresa Pediatric Asthma and Viral Infection() |
title | Pediatric Asthma and Viral Infection() |
title_full | Pediatric Asthma and Viral Infection() |
title_fullStr | Pediatric Asthma and Viral Infection() |
title_full_unstemmed | Pediatric Asthma and Viral Infection() |
title_short | Pediatric Asthma and Viral Infection() |
title_sort | pediatric asthma and viral infection() |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7105201/ https://www.ncbi.nlm.nih.gov/pubmed/26766408 http://dx.doi.org/10.1016/j.arbr.2016.03.010 |
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