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Importance of homo-dimerization of Fanconi-associated nuclease 1 in DNA flap cleavage

Fanconi-associated nuclease 1 (FAN1) removes interstrand DNA crosslinks (ICLs) through its DNA flap endonuclease and exonuclease activities. Crystal structures of human and bacterial FAN1 bound to a DNA flap have been solved. The Pseudomonas aeruginosa bacterial FAN1 and human FAN1 (hFAN1) missing a...

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Detalles Bibliográficos
Autores principales:	Rao, Timsi, Longerich, Simonne, Zhao, Weixing, Aihara, Hideki, Sung, Patrick, Xiong, Yong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier B.V. 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7105229/ https://www.ncbi.nlm.nih.gov/pubmed/29518739 http://dx.doi.org/10.1016/j.dnarep.2018.02.007

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