One-year Mortality Outcomes From the Advancing Cryptococcal Meningitis Treatment for Africa Trial of Cryptococcal Meningitis Treatment in Malawi

In Malawi, 236 participants from the Advancing Cryptococcal Meningitis Treatment for Africa trial were followed for 12 months. The trial outcomes reported at 10 weeks were sustained to 1 year. One-week amphotericin B plus flucytosine was associated with the lowest 1 year mortality (27.5% [95% confid...

Descripción completa

Detalles Bibliográficos
Autores principales: Kanyama, Cecilia, Molloy, Síle F, Chan, Adrienne K, Lupiya, Duncan, Chawinga, Chimwemwe, Adams, Jack, Bright, Philip, Lalloo, David G, Heyderman, Robert S, Lortholary, Olivier, Jaffar, Shabbar, Loyse, Angela, van Oosterhout, Joep J, Hosseinipour, Mina C, Harrison, Thomas S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7105249/
https://www.ncbi.nlm.nih.gov/pubmed/31155650
http://dx.doi.org/10.1093/cid/ciz454
_version_ 1783512368340271104
author Kanyama, Cecilia
Molloy, Síle F
Chan, Adrienne K
Lupiya, Duncan
Chawinga, Chimwemwe
Adams, Jack
Bright, Philip
Lalloo, David G
Heyderman, Robert S
Lortholary, Olivier
Jaffar, Shabbar
Loyse, Angela
van Oosterhout, Joep J
Hosseinipour, Mina C
Harrison, Thomas S
author_facet Kanyama, Cecilia
Molloy, Síle F
Chan, Adrienne K
Lupiya, Duncan
Chawinga, Chimwemwe
Adams, Jack
Bright, Philip
Lalloo, David G
Heyderman, Robert S
Lortholary, Olivier
Jaffar, Shabbar
Loyse, Angela
van Oosterhout, Joep J
Hosseinipour, Mina C
Harrison, Thomas S
author_sort Kanyama, Cecilia
collection PubMed
description In Malawi, 236 participants from the Advancing Cryptococcal Meningitis Treatment for Africa trial were followed for 12 months. The trial outcomes reported at 10 weeks were sustained to 1 year. One-week amphotericin B plus flucytosine was associated with the lowest 1 year mortality (27.5% [95% confidence interval, 16.3 to 44.1]).
format Online
Article
Text
id pubmed-7105249
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Oxford University Press
record_format MEDLINE/PubMed
spelling pubmed-71052492020-04-06 One-year Mortality Outcomes From the Advancing Cryptococcal Meningitis Treatment for Africa Trial of Cryptococcal Meningitis Treatment in Malawi Kanyama, Cecilia Molloy, Síle F Chan, Adrienne K Lupiya, Duncan Chawinga, Chimwemwe Adams, Jack Bright, Philip Lalloo, David G Heyderman, Robert S Lortholary, Olivier Jaffar, Shabbar Loyse, Angela van Oosterhout, Joep J Hosseinipour, Mina C Harrison, Thomas S Clin Infect Dis Brief Reports In Malawi, 236 participants from the Advancing Cryptococcal Meningitis Treatment for Africa trial were followed for 12 months. The trial outcomes reported at 10 weeks were sustained to 1 year. One-week amphotericin B plus flucytosine was associated with the lowest 1 year mortality (27.5% [95% confidence interval, 16.3 to 44.1]). Oxford University Press 2020-02-01 2019-06-01 /pmc/articles/PMC7105249/ /pubmed/31155650 http://dx.doi.org/10.1093/cid/ciz454 Text en © The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Reports
Kanyama, Cecilia
Molloy, Síle F
Chan, Adrienne K
Lupiya, Duncan
Chawinga, Chimwemwe
Adams, Jack
Bright, Philip
Lalloo, David G
Heyderman, Robert S
Lortholary, Olivier
Jaffar, Shabbar
Loyse, Angela
van Oosterhout, Joep J
Hosseinipour, Mina C
Harrison, Thomas S
One-year Mortality Outcomes From the Advancing Cryptococcal Meningitis Treatment for Africa Trial of Cryptococcal Meningitis Treatment in Malawi
title One-year Mortality Outcomes From the Advancing Cryptococcal Meningitis Treatment for Africa Trial of Cryptococcal Meningitis Treatment in Malawi
title_full One-year Mortality Outcomes From the Advancing Cryptococcal Meningitis Treatment for Africa Trial of Cryptococcal Meningitis Treatment in Malawi
title_fullStr One-year Mortality Outcomes From the Advancing Cryptococcal Meningitis Treatment for Africa Trial of Cryptococcal Meningitis Treatment in Malawi
title_full_unstemmed One-year Mortality Outcomes From the Advancing Cryptococcal Meningitis Treatment for Africa Trial of Cryptococcal Meningitis Treatment in Malawi
title_short One-year Mortality Outcomes From the Advancing Cryptococcal Meningitis Treatment for Africa Trial of Cryptococcal Meningitis Treatment in Malawi
title_sort one-year mortality outcomes from the advancing cryptococcal meningitis treatment for africa trial of cryptococcal meningitis treatment in malawi
topic Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7105249/
https://www.ncbi.nlm.nih.gov/pubmed/31155650
http://dx.doi.org/10.1093/cid/ciz454
work_keys_str_mv AT kanyamacecilia oneyearmortalityoutcomesfromtheadvancingcryptococcalmeningitistreatmentforafricatrialofcryptococcalmeningitistreatmentinmalawi
AT molloysilef oneyearmortalityoutcomesfromtheadvancingcryptococcalmeningitistreatmentforafricatrialofcryptococcalmeningitistreatmentinmalawi
AT chanadriennek oneyearmortalityoutcomesfromtheadvancingcryptococcalmeningitistreatmentforafricatrialofcryptococcalmeningitistreatmentinmalawi
AT lupiyaduncan oneyearmortalityoutcomesfromtheadvancingcryptococcalmeningitistreatmentforafricatrialofcryptococcalmeningitistreatmentinmalawi
AT chawingachimwemwe oneyearmortalityoutcomesfromtheadvancingcryptococcalmeningitistreatmentforafricatrialofcryptococcalmeningitistreatmentinmalawi
AT adamsjack oneyearmortalityoutcomesfromtheadvancingcryptococcalmeningitistreatmentforafricatrialofcryptococcalmeningitistreatmentinmalawi
AT brightphilip oneyearmortalityoutcomesfromtheadvancingcryptococcalmeningitistreatmentforafricatrialofcryptococcalmeningitistreatmentinmalawi
AT lalloodavidg oneyearmortalityoutcomesfromtheadvancingcryptococcalmeningitistreatmentforafricatrialofcryptococcalmeningitistreatmentinmalawi
AT heydermanroberts oneyearmortalityoutcomesfromtheadvancingcryptococcalmeningitistreatmentforafricatrialofcryptococcalmeningitistreatmentinmalawi
AT lortholaryolivier oneyearmortalityoutcomesfromtheadvancingcryptococcalmeningitistreatmentforafricatrialofcryptococcalmeningitistreatmentinmalawi
AT jaffarshabbar oneyearmortalityoutcomesfromtheadvancingcryptococcalmeningitistreatmentforafricatrialofcryptococcalmeningitistreatmentinmalawi
AT loyseangela oneyearmortalityoutcomesfromtheadvancingcryptococcalmeningitistreatmentforafricatrialofcryptococcalmeningitistreatmentinmalawi
AT vanoosterhoutjoepj oneyearmortalityoutcomesfromtheadvancingcryptococcalmeningitistreatmentforafricatrialofcryptococcalmeningitistreatmentinmalawi
AT hosseinipourminac oneyearmortalityoutcomesfromtheadvancingcryptococcalmeningitistreatmentforafricatrialofcryptococcalmeningitistreatmentinmalawi
AT harrisonthomass oneyearmortalityoutcomesfromtheadvancingcryptococcalmeningitistreatmentforafricatrialofcryptococcalmeningitistreatmentinmalawi

Ejemplares similares