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Computational study on the haemodynamic and mechanical performance of electrospun polyurethane dialysis grafts
Compliance mismatch between an arteriovenous dialysis graft (AVG) and the connected vein is believed to result in disturbed haemodynamics around the graft–vein anastomosis and increased mechanical loading of the vein. Both phenomena are associated with neointimal hyperplasia development, which is th...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7105427/ https://www.ncbi.nlm.nih.gov/pubmed/31679093 http://dx.doi.org/10.1007/s10237-019-01242-1 |
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author | Quicken, Sjeng de Bruin, Yeshi Mees, Barend Tordoir, Jan Delhaas, Tammo Huberts, Wouter |
author_facet | Quicken, Sjeng de Bruin, Yeshi Mees, Barend Tordoir, Jan Delhaas, Tammo Huberts, Wouter |
author_sort | Quicken, Sjeng |
collection | PubMed |
description | Compliance mismatch between an arteriovenous dialysis graft (AVG) and the connected vein is believed to result in disturbed haemodynamics around the graft–vein anastomosis and increased mechanical loading of the vein. Both phenomena are associated with neointimal hyperplasia development, which is the main reason for AVG patency loss. In this study, we use a patient-specific fluid structure interaction AVG model to assess whether AVG haemodynamics and mechanical loading can be optimised by using novel electrospun polyurethane (ePU) grafts, since their compliance can be better tuned to match that of the native veins, compared to gold standard, expanded polytetrafluoroethylene (ePTFE) grafts. It was observed that the magnitude of flow disturbances in the vein and the size of anastomotic areas exposed to highly oscillatory shear ([Formula: see text] ) and very high wall shear stress ([Formula: see text] ) were largest for the ePTFE graft. Median strain and von Mises stress in the vein were similar for both graft types, whereas highest stress and strain were observed in the anastomosis of the ePU graft. Since haemodynamics were most favourable for the ePU graft simulation, AVG longevity might be improved by the use of ePU grafts. |
format | Online Article Text |
id | pubmed-7105427 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-71054272020-04-03 Computational study on the haemodynamic and mechanical performance of electrospun polyurethane dialysis grafts Quicken, Sjeng de Bruin, Yeshi Mees, Barend Tordoir, Jan Delhaas, Tammo Huberts, Wouter Biomech Model Mechanobiol Original Paper Compliance mismatch between an arteriovenous dialysis graft (AVG) and the connected vein is believed to result in disturbed haemodynamics around the graft–vein anastomosis and increased mechanical loading of the vein. Both phenomena are associated with neointimal hyperplasia development, which is the main reason for AVG patency loss. In this study, we use a patient-specific fluid structure interaction AVG model to assess whether AVG haemodynamics and mechanical loading can be optimised by using novel electrospun polyurethane (ePU) grafts, since their compliance can be better tuned to match that of the native veins, compared to gold standard, expanded polytetrafluoroethylene (ePTFE) grafts. It was observed that the magnitude of flow disturbances in the vein and the size of anastomotic areas exposed to highly oscillatory shear ([Formula: see text] ) and very high wall shear stress ([Formula: see text] ) were largest for the ePTFE graft. Median strain and von Mises stress in the vein were similar for both graft types, whereas highest stress and strain were observed in the anastomosis of the ePU graft. Since haemodynamics were most favourable for the ePU graft simulation, AVG longevity might be improved by the use of ePU grafts. Springer Berlin Heidelberg 2019-11-02 2020 /pmc/articles/PMC7105427/ /pubmed/31679093 http://dx.doi.org/10.1007/s10237-019-01242-1 Text en © The Author(s) 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Original Paper Quicken, Sjeng de Bruin, Yeshi Mees, Barend Tordoir, Jan Delhaas, Tammo Huberts, Wouter Computational study on the haemodynamic and mechanical performance of electrospun polyurethane dialysis grafts |
title | Computational study on the haemodynamic and mechanical performance of electrospun polyurethane dialysis grafts |
title_full | Computational study on the haemodynamic and mechanical performance of electrospun polyurethane dialysis grafts |
title_fullStr | Computational study on the haemodynamic and mechanical performance of electrospun polyurethane dialysis grafts |
title_full_unstemmed | Computational study on the haemodynamic and mechanical performance of electrospun polyurethane dialysis grafts |
title_short | Computational study on the haemodynamic and mechanical performance of electrospun polyurethane dialysis grafts |
title_sort | computational study on the haemodynamic and mechanical performance of electrospun polyurethane dialysis grafts |
topic | Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7105427/ https://www.ncbi.nlm.nih.gov/pubmed/31679093 http://dx.doi.org/10.1007/s10237-019-01242-1 |
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