Cargando…

Computational study on the haemodynamic and mechanical performance of electrospun polyurethane dialysis grafts

Compliance mismatch between an arteriovenous dialysis graft (AVG) and the connected vein is believed to result in disturbed haemodynamics around the graft–vein anastomosis and increased mechanical loading of the vein. Both phenomena are associated with neointimal hyperplasia development, which is th...

Descripción completa

Detalles Bibliográficos
Autores principales: Quicken, Sjeng, de Bruin, Yeshi, Mees, Barend, Tordoir, Jan, Delhaas, Tammo, Huberts, Wouter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7105427/
https://www.ncbi.nlm.nih.gov/pubmed/31679093
http://dx.doi.org/10.1007/s10237-019-01242-1
_version_ 1783512398573862912
author Quicken, Sjeng
de Bruin, Yeshi
Mees, Barend
Tordoir, Jan
Delhaas, Tammo
Huberts, Wouter
author_facet Quicken, Sjeng
de Bruin, Yeshi
Mees, Barend
Tordoir, Jan
Delhaas, Tammo
Huberts, Wouter
author_sort Quicken, Sjeng
collection PubMed
description Compliance mismatch between an arteriovenous dialysis graft (AVG) and the connected vein is believed to result in disturbed haemodynamics around the graft–vein anastomosis and increased mechanical loading of the vein. Both phenomena are associated with neointimal hyperplasia development, which is the main reason for AVG patency loss. In this study, we use a patient-specific fluid structure interaction AVG model to assess whether AVG haemodynamics and mechanical loading can be optimised by using novel electrospun polyurethane (ePU) grafts, since their compliance can be better tuned to match that of the native veins, compared to gold standard, expanded polytetrafluoroethylene (ePTFE) grafts. It was observed that the magnitude of flow disturbances in the vein and the size of anastomotic areas exposed to highly oscillatory shear ([Formula: see text] ) and very high wall shear stress ([Formula: see text] ) were largest for the ePTFE graft. Median strain and von Mises stress in the vein were similar for both graft types, whereas highest stress and strain were observed in the anastomosis of the ePU graft. Since haemodynamics were most favourable for the ePU graft simulation, AVG longevity might be improved by the use of ePU grafts.
format Online
Article
Text
id pubmed-7105427
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Springer Berlin Heidelberg
record_format MEDLINE/PubMed
spelling pubmed-71054272020-04-03 Computational study on the haemodynamic and mechanical performance of electrospun polyurethane dialysis grafts Quicken, Sjeng de Bruin, Yeshi Mees, Barend Tordoir, Jan Delhaas, Tammo Huberts, Wouter Biomech Model Mechanobiol Original Paper Compliance mismatch between an arteriovenous dialysis graft (AVG) and the connected vein is believed to result in disturbed haemodynamics around the graft–vein anastomosis and increased mechanical loading of the vein. Both phenomena are associated with neointimal hyperplasia development, which is the main reason for AVG patency loss. In this study, we use a patient-specific fluid structure interaction AVG model to assess whether AVG haemodynamics and mechanical loading can be optimised by using novel electrospun polyurethane (ePU) grafts, since their compliance can be better tuned to match that of the native veins, compared to gold standard, expanded polytetrafluoroethylene (ePTFE) grafts. It was observed that the magnitude of flow disturbances in the vein and the size of anastomotic areas exposed to highly oscillatory shear ([Formula: see text] ) and very high wall shear stress ([Formula: see text] ) were largest for the ePTFE graft. Median strain and von Mises stress in the vein were similar for both graft types, whereas highest stress and strain were observed in the anastomosis of the ePU graft. Since haemodynamics were most favourable for the ePU graft simulation, AVG longevity might be improved by the use of ePU grafts. Springer Berlin Heidelberg 2019-11-02 2020 /pmc/articles/PMC7105427/ /pubmed/31679093 http://dx.doi.org/10.1007/s10237-019-01242-1 Text en © The Author(s) 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Original Paper
Quicken, Sjeng
de Bruin, Yeshi
Mees, Barend
Tordoir, Jan
Delhaas, Tammo
Huberts, Wouter
Computational study on the haemodynamic and mechanical performance of electrospun polyurethane dialysis grafts
title Computational study on the haemodynamic and mechanical performance of electrospun polyurethane dialysis grafts
title_full Computational study on the haemodynamic and mechanical performance of electrospun polyurethane dialysis grafts
title_fullStr Computational study on the haemodynamic and mechanical performance of electrospun polyurethane dialysis grafts
title_full_unstemmed Computational study on the haemodynamic and mechanical performance of electrospun polyurethane dialysis grafts
title_short Computational study on the haemodynamic and mechanical performance of electrospun polyurethane dialysis grafts
title_sort computational study on the haemodynamic and mechanical performance of electrospun polyurethane dialysis grafts
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7105427/
https://www.ncbi.nlm.nih.gov/pubmed/31679093
http://dx.doi.org/10.1007/s10237-019-01242-1
work_keys_str_mv AT quickensjeng computationalstudyonthehaemodynamicandmechanicalperformanceofelectrospunpolyurethanedialysisgrafts
AT debruinyeshi computationalstudyonthehaemodynamicandmechanicalperformanceofelectrospunpolyurethanedialysisgrafts
AT meesbarend computationalstudyonthehaemodynamicandmechanicalperformanceofelectrospunpolyurethanedialysisgrafts
AT tordoirjan computationalstudyonthehaemodynamicandmechanicalperformanceofelectrospunpolyurethanedialysisgrafts
AT delhaastammo computationalstudyonthehaemodynamicandmechanicalperformanceofelectrospunpolyurethanedialysisgrafts
AT hubertswouter computationalstudyonthehaemodynamicandmechanicalperformanceofelectrospunpolyurethanedialysisgrafts