Life, death, and autophagy in cancer: NF-κB turns up everywhere

Escaping programmed cell death is a hallmark of cancer. NF-κB transcription factors are key regulator of cell survival and aberrant NF-κB signaling has been involved in the pathogenesis of most human malignancies. Although NF-κB is best known for its antiapoptotic role, other processes regulating th...

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Autores principales: Verzella, Daniela, Pescatore, Alessandra, Capece, Daria, Vecchiotti, Davide, Ursini, Matilde Valeria, Franzoso, Guido, Alesse, Edoardo, Zazzeroni, Francesca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7105474/
https://www.ncbi.nlm.nih.gov/pubmed/32231206
http://dx.doi.org/10.1038/s41419-020-2399-y
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author Verzella, Daniela
Pescatore, Alessandra
Capece, Daria
Vecchiotti, Davide
Ursini, Matilde Valeria
Franzoso, Guido
Alesse, Edoardo
Zazzeroni, Francesca
author_facet Verzella, Daniela
Pescatore, Alessandra
Capece, Daria
Vecchiotti, Davide
Ursini, Matilde Valeria
Franzoso, Guido
Alesse, Edoardo
Zazzeroni, Francesca
author_sort Verzella, Daniela
collection PubMed
description Escaping programmed cell death is a hallmark of cancer. NF-κB transcription factors are key regulator of cell survival and aberrant NF-κB signaling has been involved in the pathogenesis of most human malignancies. Although NF-κB is best known for its antiapoptotic role, other processes regulating the life/death balance, such as autophagy and necroptosis, seem to network with NF-κB. This review discusses how the reciprocal regulation of NF-κB, autophagy and programmed cell death affect cancer development and progression.
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spelling pubmed-71054742020-03-31 Life, death, and autophagy in cancer: NF-κB turns up everywhere Verzella, Daniela Pescatore, Alessandra Capece, Daria Vecchiotti, Davide Ursini, Matilde Valeria Franzoso, Guido Alesse, Edoardo Zazzeroni, Francesca Cell Death Dis Review Article Escaping programmed cell death is a hallmark of cancer. NF-κB transcription factors are key regulator of cell survival and aberrant NF-κB signaling has been involved in the pathogenesis of most human malignancies. Although NF-κB is best known for its antiapoptotic role, other processes regulating the life/death balance, such as autophagy and necroptosis, seem to network with NF-κB. This review discusses how the reciprocal regulation of NF-κB, autophagy and programmed cell death affect cancer development and progression. Nature Publishing Group UK 2020-03-30 /pmc/articles/PMC7105474/ /pubmed/32231206 http://dx.doi.org/10.1038/s41419-020-2399-y Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Review Article
Verzella, Daniela
Pescatore, Alessandra
Capece, Daria
Vecchiotti, Davide
Ursini, Matilde Valeria
Franzoso, Guido
Alesse, Edoardo
Zazzeroni, Francesca
Life, death, and autophagy in cancer: NF-κB turns up everywhere
title Life, death, and autophagy in cancer: NF-κB turns up everywhere
title_full Life, death, and autophagy in cancer: NF-κB turns up everywhere
title_fullStr Life, death, and autophagy in cancer: NF-κB turns up everywhere
title_full_unstemmed Life, death, and autophagy in cancer: NF-κB turns up everywhere
title_short Life, death, and autophagy in cancer: NF-κB turns up everywhere
title_sort life, death, and autophagy in cancer: nf-κb turns up everywhere
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7105474/
https://www.ncbi.nlm.nih.gov/pubmed/32231206
http://dx.doi.org/10.1038/s41419-020-2399-y
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