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Nuclear Factor κB (NF-κB)–Mediated Inflammation in Multiple Sclerosis
The nuclear factor κB (NF-κB) signaling cascade has been implicating in a broad range of biological processes, including inflammation, cell proliferation, differentiation, and apoptosis. The past three decades have witnessed a great progress in understanding the impact of aberrant NF-κB regulation o...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7105607/ https://www.ncbi.nlm.nih.gov/pubmed/32265906 http://dx.doi.org/10.3389/fimmu.2020.00391 |
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author | Zhou, Yifan Cui, Chunping Ma, Xiaoyu Luo, Wenjing Zheng, Song Guo Qiu, Wei |
author_facet | Zhou, Yifan Cui, Chunping Ma, Xiaoyu Luo, Wenjing Zheng, Song Guo Qiu, Wei |
author_sort | Zhou, Yifan |
collection | PubMed |
description | The nuclear factor κB (NF-κB) signaling cascade has been implicating in a broad range of biological processes, including inflammation, cell proliferation, differentiation, and apoptosis. The past three decades have witnessed a great progress in understanding the impact of aberrant NF-κB regulation on human autoimmune and inflammatory disorders. In this review, we discuss how aberrant NF-κB activation contributes to multiple sclerosis, a typical inflammatory demyelinating disease of the central nervous system, and its involvement in developing potential therapeutic targets. |
format | Online Article Text |
id | pubmed-7105607 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-71056072020-04-07 Nuclear Factor κB (NF-κB)–Mediated Inflammation in Multiple Sclerosis Zhou, Yifan Cui, Chunping Ma, Xiaoyu Luo, Wenjing Zheng, Song Guo Qiu, Wei Front Immunol Immunology The nuclear factor κB (NF-κB) signaling cascade has been implicating in a broad range of biological processes, including inflammation, cell proliferation, differentiation, and apoptosis. The past three decades have witnessed a great progress in understanding the impact of aberrant NF-κB regulation on human autoimmune and inflammatory disorders. In this review, we discuss how aberrant NF-κB activation contributes to multiple sclerosis, a typical inflammatory demyelinating disease of the central nervous system, and its involvement in developing potential therapeutic targets. Frontiers Media S.A. 2020-03-24 /pmc/articles/PMC7105607/ /pubmed/32265906 http://dx.doi.org/10.3389/fimmu.2020.00391 Text en Copyright © 2020 Zhou, Cui, Ma, Luo, Zheng and Qiu. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Zhou, Yifan Cui, Chunping Ma, Xiaoyu Luo, Wenjing Zheng, Song Guo Qiu, Wei Nuclear Factor κB (NF-κB)–Mediated Inflammation in Multiple Sclerosis |
title | Nuclear Factor κB (NF-κB)–Mediated Inflammation in Multiple Sclerosis |
title_full | Nuclear Factor κB (NF-κB)–Mediated Inflammation in Multiple Sclerosis |
title_fullStr | Nuclear Factor κB (NF-κB)–Mediated Inflammation in Multiple Sclerosis |
title_full_unstemmed | Nuclear Factor κB (NF-κB)–Mediated Inflammation in Multiple Sclerosis |
title_short | Nuclear Factor κB (NF-κB)–Mediated Inflammation in Multiple Sclerosis |
title_sort | nuclear factor κb (nf-κb)–mediated inflammation in multiple sclerosis |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7105607/ https://www.ncbi.nlm.nih.gov/pubmed/32265906 http://dx.doi.org/10.3389/fimmu.2020.00391 |
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