Nuclear Factor κB (NF-κB)–Mediated Inflammation in Multiple Sclerosis

The nuclear factor κB (NF-κB) signaling cascade has been implicating in a broad range of biological processes, including inflammation, cell proliferation, differentiation, and apoptosis. The past three decades have witnessed a great progress in understanding the impact of aberrant NF-κB regulation o...

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Autores principales: Zhou, Yifan, Cui, Chunping, Ma, Xiaoyu, Luo, Wenjing, Zheng, Song Guo, Qiu, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7105607/
https://www.ncbi.nlm.nih.gov/pubmed/32265906
http://dx.doi.org/10.3389/fimmu.2020.00391
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author Zhou, Yifan
Cui, Chunping
Ma, Xiaoyu
Luo, Wenjing
Zheng, Song Guo
Qiu, Wei
author_facet Zhou, Yifan
Cui, Chunping
Ma, Xiaoyu
Luo, Wenjing
Zheng, Song Guo
Qiu, Wei
author_sort Zhou, Yifan
collection PubMed
description The nuclear factor κB (NF-κB) signaling cascade has been implicating in a broad range of biological processes, including inflammation, cell proliferation, differentiation, and apoptosis. The past three decades have witnessed a great progress in understanding the impact of aberrant NF-κB regulation on human autoimmune and inflammatory disorders. In this review, we discuss how aberrant NF-κB activation contributes to multiple sclerosis, a typical inflammatory demyelinating disease of the central nervous system, and its involvement in developing potential therapeutic targets.
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spelling pubmed-71056072020-04-07 Nuclear Factor κB (NF-κB)–Mediated Inflammation in Multiple Sclerosis Zhou, Yifan Cui, Chunping Ma, Xiaoyu Luo, Wenjing Zheng, Song Guo Qiu, Wei Front Immunol Immunology The nuclear factor κB (NF-κB) signaling cascade has been implicating in a broad range of biological processes, including inflammation, cell proliferation, differentiation, and apoptosis. The past three decades have witnessed a great progress in understanding the impact of aberrant NF-κB regulation on human autoimmune and inflammatory disorders. In this review, we discuss how aberrant NF-κB activation contributes to multiple sclerosis, a typical inflammatory demyelinating disease of the central nervous system, and its involvement in developing potential therapeutic targets. Frontiers Media S.A. 2020-03-24 /pmc/articles/PMC7105607/ /pubmed/32265906 http://dx.doi.org/10.3389/fimmu.2020.00391 Text en Copyright © 2020 Zhou, Cui, Ma, Luo, Zheng and Qiu. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Zhou, Yifan
Cui, Chunping
Ma, Xiaoyu
Luo, Wenjing
Zheng, Song Guo
Qiu, Wei
Nuclear Factor κB (NF-κB)–Mediated Inflammation in Multiple Sclerosis
title Nuclear Factor κB (NF-κB)–Mediated Inflammation in Multiple Sclerosis
title_full Nuclear Factor κB (NF-κB)–Mediated Inflammation in Multiple Sclerosis
title_fullStr Nuclear Factor κB (NF-κB)–Mediated Inflammation in Multiple Sclerosis
title_full_unstemmed Nuclear Factor κB (NF-κB)–Mediated Inflammation in Multiple Sclerosis
title_short Nuclear Factor κB (NF-κB)–Mediated Inflammation in Multiple Sclerosis
title_sort nuclear factor κb (nf-κb)–mediated inflammation in multiple sclerosis
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7105607/
https://www.ncbi.nlm.nih.gov/pubmed/32265906
http://dx.doi.org/10.3389/fimmu.2020.00391
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