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The Role of PD-1 in Acute and Chronic Infection

PD-1 as an immune checkpoint molecule down-regulates T cell activity during immune responses in order to prevent autoimmune tissue damage. In chronic infections or tumors, lasting antigen-exposure leads to permanent PD-1 expression that can limit immune-mediated clearance of pathogens or degenerated...

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Detalles Bibliográficos
Autores principales:	Jubel, Jil M., Barbati, Zachary R., Burger, Christof, Wirtz, Dieter C., Schildberg, Frank A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7105608/ https://www.ncbi.nlm.nih.gov/pubmed/32265932 http://dx.doi.org/10.3389/fimmu.2020.00487

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