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The Role of PD-1 in Acute and Chronic Infection
PD-1 as an immune checkpoint molecule down-regulates T cell activity during immune responses in order to prevent autoimmune tissue damage. In chronic infections or tumors, lasting antigen-exposure leads to permanent PD-1 expression that can limit immune-mediated clearance of pathogens or degenerated...
Autores principales: | Jubel, Jil M., Barbati, Zachary R., Burger, Christof, Wirtz, Dieter C., Schildberg, Frank A. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7105608/ https://www.ncbi.nlm.nih.gov/pubmed/32265932 http://dx.doi.org/10.3389/fimmu.2020.00487 |
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