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Effects of online hemodiafiltration on anemia and nutritional status in chronic hemodialysis patients
BACKGROUND: Online hemodiafiltration (OL-HDF) offers considerable advantages in clearance of molecules of various sizes. However, evidence of clinical effects of OL-HDF is scarce in Korea. In this study, we investigated changes in laboratory values over more than 12 months after switching to OL-HDF....
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Society of Nephrology
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7105619/ https://www.ncbi.nlm.nih.gov/pubmed/32036641 http://dx.doi.org/10.23876/j.krcp.19.082 |
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author | Lee, Yu Ho Shin, Yoon Soo Lee, So-Young Kim, Yang Gyun Lee, Sang Ho Moon, Ju Young Jeong, Kyung Hwan Hwang, Hyeon Seok Ahn, Shin Young Lee, Hong Joo Lee, Dong-Young Ko, Eun-Jung Cho, Hye Jeong Yang, Dong Ho Jeong, Hye Yun |
author_facet | Lee, Yu Ho Shin, Yoon Soo Lee, So-Young Kim, Yang Gyun Lee, Sang Ho Moon, Ju Young Jeong, Kyung Hwan Hwang, Hyeon Seok Ahn, Shin Young Lee, Hong Joo Lee, Dong-Young Ko, Eun-Jung Cho, Hye Jeong Yang, Dong Ho Jeong, Hye Yun |
author_sort | Lee, Yu Ho |
collection | PubMed |
description | BACKGROUND: Online hemodiafiltration (OL-HDF) offers considerable advantages in clearance of molecules of various sizes. However, evidence of clinical effects of OL-HDF is scarce in Korea. In this study, we investigated changes in laboratory values over more than 12 months after switching to OL-HDF. METHODS: Adult patients with end-stage renal disease undergoing hemodialysis (HD) were prospectively enrolled in a K-cohort (CRIS no. KCT0003281) from 6 tertiary hospitals in South Korea. We recruited 435 patients, 339 of whom were on HD at enrollment. One hundred eighty-two patients were followed for more than 24 months. Among them, 44 were switched to OL-HDF for more than 12 months without conversion to HD. We used a paired t test to compare baseline and 24-month follow-up results. RESULTS: The mean age of the subjects was 61.2 ± 12.2 years, and 62.6% were male. The baseline hemoglobin level was not significantly different between HD and OL-HDF group (10.61 ± 1.15 vs. 10.46 ± 1.03 g/dL, P = 0.437). However, the baseline serum protein and albumin levels were significantly lower in the OL-HDF group (6.82 ± 0.49 vs. 6.59 ± 0.48 g/dL, P = 0.006; 3.93 ± 0.28 vs. 3.73 ± 0.29 g/dL, P < 0.001). In patients switched to OL-HDF, levels of hemoglobin and serum albumin significantly increased (10.46 ± 1.03 vs. 11.08 ± 0.82 g/dL, P = 0.001; 3.73 ± 0.29 vs. 3.87 ± 0.30 g/dL, P = 0.001). The normalized protein catabolic rate decreased after 24 months, but the change was not significant (1.07 ± 0.25 vs. 1.03 ± 0.21 g/kg/day, P = 0.433). Although the dose of erythropoiesis-stimulating agent was lower in patients who converted to HDF, it was not significantly different (-115.7 ± 189.7 vs. -170.5 ± 257.1 P = 0.206). CONCLUSION: OL-HDF treatment over more than 12 months was associated with no harmful effects on anemia and nutritional status. |
format | Online Article Text |
id | pubmed-7105619 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Korean Society of Nephrology |
record_format | MEDLINE/PubMed |
spelling | pubmed-71056192020-04-09 Effects of online hemodiafiltration on anemia and nutritional status in chronic hemodialysis patients Lee, Yu Ho Shin, Yoon Soo Lee, So-Young Kim, Yang Gyun Lee, Sang Ho Moon, Ju Young Jeong, Kyung Hwan Hwang, Hyeon Seok Ahn, Shin Young Lee, Hong Joo Lee, Dong-Young Ko, Eun-Jung Cho, Hye Jeong Yang, Dong Ho Jeong, Hye Yun Kidney Res Clin Pract Original Article BACKGROUND: Online hemodiafiltration (OL-HDF) offers considerable advantages in clearance of molecules of various sizes. However, evidence of clinical effects of OL-HDF is scarce in Korea. In this study, we investigated changes in laboratory values over more than 12 months after switching to OL-HDF. METHODS: Adult patients with end-stage renal disease undergoing hemodialysis (HD) were prospectively enrolled in a K-cohort (CRIS no. KCT0003281) from 6 tertiary hospitals in South Korea. We recruited 435 patients, 339 of whom were on HD at enrollment. One hundred eighty-two patients were followed for more than 24 months. Among them, 44 were switched to OL-HDF for more than 12 months without conversion to HD. We used a paired t test to compare baseline and 24-month follow-up results. RESULTS: The mean age of the subjects was 61.2 ± 12.2 years, and 62.6% were male. The baseline hemoglobin level was not significantly different between HD and OL-HDF group (10.61 ± 1.15 vs. 10.46 ± 1.03 g/dL, P = 0.437). However, the baseline serum protein and albumin levels were significantly lower in the OL-HDF group (6.82 ± 0.49 vs. 6.59 ± 0.48 g/dL, P = 0.006; 3.93 ± 0.28 vs. 3.73 ± 0.29 g/dL, P < 0.001). In patients switched to OL-HDF, levels of hemoglobin and serum albumin significantly increased (10.46 ± 1.03 vs. 11.08 ± 0.82 g/dL, P = 0.001; 3.73 ± 0.29 vs. 3.87 ± 0.30 g/dL, P = 0.001). The normalized protein catabolic rate decreased after 24 months, but the change was not significant (1.07 ± 0.25 vs. 1.03 ± 0.21 g/kg/day, P = 0.433). Although the dose of erythropoiesis-stimulating agent was lower in patients who converted to HDF, it was not significantly different (-115.7 ± 189.7 vs. -170.5 ± 257.1 P = 0.206). CONCLUSION: OL-HDF treatment over more than 12 months was associated with no harmful effects on anemia and nutritional status. Korean Society of Nephrology 2020-03-31 2020-03-31 /pmc/articles/PMC7105619/ /pubmed/32036641 http://dx.doi.org/10.23876/j.krcp.19.082 Text en Copyright © 2020 by The Korean Society of Nephrology This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Lee, Yu Ho Shin, Yoon Soo Lee, So-Young Kim, Yang Gyun Lee, Sang Ho Moon, Ju Young Jeong, Kyung Hwan Hwang, Hyeon Seok Ahn, Shin Young Lee, Hong Joo Lee, Dong-Young Ko, Eun-Jung Cho, Hye Jeong Yang, Dong Ho Jeong, Hye Yun Effects of online hemodiafiltration on anemia and nutritional status in chronic hemodialysis patients |
title | Effects of online hemodiafiltration on anemia and nutritional status in chronic hemodialysis patients |
title_full | Effects of online hemodiafiltration on anemia and nutritional status in chronic hemodialysis patients |
title_fullStr | Effects of online hemodiafiltration on anemia and nutritional status in chronic hemodialysis patients |
title_full_unstemmed | Effects of online hemodiafiltration on anemia and nutritional status in chronic hemodialysis patients |
title_short | Effects of online hemodiafiltration on anemia and nutritional status in chronic hemodialysis patients |
title_sort | effects of online hemodiafiltration on anemia and nutritional status in chronic hemodialysis patients |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7105619/ https://www.ncbi.nlm.nih.gov/pubmed/32036641 http://dx.doi.org/10.23876/j.krcp.19.082 |
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