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Intensity of statin therapy and renal outcome in chronic kidney disease: Results from the Korean Cohort Study for Outcome in Patients With Chronic Kidney Disease
BACKGROUND: Higher statin intensity is associated with a lower risk of mortality in patients with cardiovascular disease. However, little is known about the relationship between statin intensity and chronic kidney disease (CKD) progression. METHODS: We studied whether statin intensity affects kidney...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Society of Nephrology
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7105621/ https://www.ncbi.nlm.nih.gov/pubmed/32182639 http://dx.doi.org/10.23876/j.krcp.20.007 |
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author | Jhee, Jong Hyun Joo, Young Su Park, Jung Tak Yoo, Tae-Hyun Park, Sue Kyung Jung, Ji Yong Kim, Soo Wan Oh, Yun Kyu Oh, Kook-Hwan Kang, Shin-Wook Choi, Kyu Hun Ahn, Curie Han, Seung Hyeok |
author_facet | Jhee, Jong Hyun Joo, Young Su Park, Jung Tak Yoo, Tae-Hyun Park, Sue Kyung Jung, Ji Yong Kim, Soo Wan Oh, Yun Kyu Oh, Kook-Hwan Kang, Shin-Wook Choi, Kyu Hun Ahn, Curie Han, Seung Hyeok |
author_sort | Jhee, Jong Hyun |
collection | PubMed |
description | BACKGROUND: Higher statin intensity is associated with a lower risk of mortality in patients with cardiovascular disease. However, little is known about the relationship between statin intensity and chronic kidney disease (CKD) progression. METHODS: We studied whether statin intensity affects kidney function decline in 1,073 patients from the Korean Cohort Study for Outcome in Patients With Chronic Kidney Disease. The participants were classified based on statin intensity as low, moderate, and high. The study endpoint was CKD progression (composite of doubling of serum creatinine, ≥ 50% decrease in estimated glomerular filtration rate [eGFR] from baseline, or end-stage renal disease). RESULTS: The mean age was 56.0 ± 11.4 years, and 665 (62.0%) participants were male. The mean eGFR was 51.7 ± 26.7 mL/min/1.73 m(2); there were no differences in baseline eGFR among statin intensity groups. During the median follow-up of 39.9 (25.4-61.6) months, 255 (23.8%) patients reached the study endpoint. In multivariable Cox model after adjustment of confounders, the hazard ratios (95% confidence interval) for adverse kidney outcome were 0.97 (0.72-1.30) and 1.15 (0.60-2.20) in moderate and high statin intensity groups, respectively, compared with the low intensity group. In addition, no significant association was observed in subgroups stratified by age, sex, eGFR, and atherosclerotic cardiovascular disease risk scores. CONCLUSION: We did not observe any significant association between intensity of statin therapy and progression of CKD. Long-term kidney outcomes may not be affected by statin intensity. |
format | Online Article Text |
id | pubmed-7105621 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Korean Society of Nephrology |
record_format | MEDLINE/PubMed |
spelling | pubmed-71056212020-04-09 Intensity of statin therapy and renal outcome in chronic kidney disease: Results from the Korean Cohort Study for Outcome in Patients With Chronic Kidney Disease Jhee, Jong Hyun Joo, Young Su Park, Jung Tak Yoo, Tae-Hyun Park, Sue Kyung Jung, Ji Yong Kim, Soo Wan Oh, Yun Kyu Oh, Kook-Hwan Kang, Shin-Wook Choi, Kyu Hun Ahn, Curie Han, Seung Hyeok Kidney Res Clin Pract Original Article BACKGROUND: Higher statin intensity is associated with a lower risk of mortality in patients with cardiovascular disease. However, little is known about the relationship between statin intensity and chronic kidney disease (CKD) progression. METHODS: We studied whether statin intensity affects kidney function decline in 1,073 patients from the Korean Cohort Study for Outcome in Patients With Chronic Kidney Disease. The participants were classified based on statin intensity as low, moderate, and high. The study endpoint was CKD progression (composite of doubling of serum creatinine, ≥ 50% decrease in estimated glomerular filtration rate [eGFR] from baseline, or end-stage renal disease). RESULTS: The mean age was 56.0 ± 11.4 years, and 665 (62.0%) participants were male. The mean eGFR was 51.7 ± 26.7 mL/min/1.73 m(2); there were no differences in baseline eGFR among statin intensity groups. During the median follow-up of 39.9 (25.4-61.6) months, 255 (23.8%) patients reached the study endpoint. In multivariable Cox model after adjustment of confounders, the hazard ratios (95% confidence interval) for adverse kidney outcome were 0.97 (0.72-1.30) and 1.15 (0.60-2.20) in moderate and high statin intensity groups, respectively, compared with the low intensity group. In addition, no significant association was observed in subgroups stratified by age, sex, eGFR, and atherosclerotic cardiovascular disease risk scores. CONCLUSION: We did not observe any significant association between intensity of statin therapy and progression of CKD. Long-term kidney outcomes may not be affected by statin intensity. Korean Society of Nephrology 2020-03-31 2020-03-31 /pmc/articles/PMC7105621/ /pubmed/32182639 http://dx.doi.org/10.23876/j.krcp.20.007 Text en Copyright © 2020 by The Korean Society of Nephrology This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Jhee, Jong Hyun Joo, Young Su Park, Jung Tak Yoo, Tae-Hyun Park, Sue Kyung Jung, Ji Yong Kim, Soo Wan Oh, Yun Kyu Oh, Kook-Hwan Kang, Shin-Wook Choi, Kyu Hun Ahn, Curie Han, Seung Hyeok Intensity of statin therapy and renal outcome in chronic kidney disease: Results from the Korean Cohort Study for Outcome in Patients With Chronic Kidney Disease |
title | Intensity of statin therapy and renal outcome in chronic kidney disease: Results from the Korean Cohort Study for Outcome in Patients With Chronic Kidney Disease |
title_full | Intensity of statin therapy and renal outcome in chronic kidney disease: Results from the Korean Cohort Study for Outcome in Patients With Chronic Kidney Disease |
title_fullStr | Intensity of statin therapy and renal outcome in chronic kidney disease: Results from the Korean Cohort Study for Outcome in Patients With Chronic Kidney Disease |
title_full_unstemmed | Intensity of statin therapy and renal outcome in chronic kidney disease: Results from the Korean Cohort Study for Outcome in Patients With Chronic Kidney Disease |
title_short | Intensity of statin therapy and renal outcome in chronic kidney disease: Results from the Korean Cohort Study for Outcome in Patients With Chronic Kidney Disease |
title_sort | intensity of statin therapy and renal outcome in chronic kidney disease: results from the korean cohort study for outcome in patients with chronic kidney disease |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7105621/ https://www.ncbi.nlm.nih.gov/pubmed/32182639 http://dx.doi.org/10.23876/j.krcp.20.007 |
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