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CDKN2a/p16 Antagonizes Hepatic Stellate Cell Activation and Liver Fibrosis by Modulating ROS Levels

The lipid-storage hepatic stellate cells (HSC) play as pivotal role in liver fibrosis being able to trans-differentiate into myofibroblasts in response to various pro-fibrogenic stimuli. In the present study we investigated the role of CDKN2a/p16, a negative regulator of cell cycling, in HSC activat...

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Detalles Bibliográficos
Autores principales:	Lv, Fangqiao, Li, Nan, Kong, Ming, Wu, Jun, Fan, Zhiwen, Miao, Dengshun, Xu, Yong, Ye, Qing, Wang, Yutong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Cell and Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7105638/ https://www.ncbi.nlm.nih.gov/pubmed/32266258 http://dx.doi.org/10.3389/fcell.2020.00176

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