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Comparison of Short and Long-Term Outcomes of Metabolic and Bariatric Surgery in Adolescents and Adults

Objective: We sought to compare the short and long-term outcomes of MBS in adolescents vs. adults who have undergone a Roux-en-Y gastric bypass (RYGB) or Sleeve gastrectomy (SG). Design: Retrospective cohort study. Setting: Single tertiary care academic referral center. Participants: One hundred fif...

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Autores principales: Stanford, Fatima Cody, Mushannen, Tasnim, Cortez, Priscilla, Campoverde Reyes, Karen J., Lee, Hang, Gee, Denise W., Pratt, Janey S., Boepple, Paul A., Bredella, Miriam A., Misra, Madhusmita, Singhal, Vibha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7105703/
https://www.ncbi.nlm.nih.gov/pubmed/32265846
http://dx.doi.org/10.3389/fendo.2020.00157
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author Stanford, Fatima Cody
Mushannen, Tasnim
Cortez, Priscilla
Campoverde Reyes, Karen J.
Lee, Hang
Gee, Denise W.
Pratt, Janey S.
Boepple, Paul A.
Bredella, Miriam A.
Misra, Madhusmita
Singhal, Vibha
author_facet Stanford, Fatima Cody
Mushannen, Tasnim
Cortez, Priscilla
Campoverde Reyes, Karen J.
Lee, Hang
Gee, Denise W.
Pratt, Janey S.
Boepple, Paul A.
Bredella, Miriam A.
Misra, Madhusmita
Singhal, Vibha
author_sort Stanford, Fatima Cody
collection PubMed
description Objective: We sought to compare the short and long-term outcomes of MBS in adolescents vs. adults who have undergone a Roux-en-Y gastric bypass (RYGB) or Sleeve gastrectomy (SG). Design: Retrospective cohort study. Setting: Single tertiary care academic referral center. Participants: One hundred fifty adolescent (≤ 21-years) and adult (>21-years) subjects with severe obesity between 15 and 70 years of age who underwent RYGB or SG. Outcomes: Metabolic parameters, weight and height measures were obtained pre-and post-surgery (at 3 and 6 months, and then annually for 4 years). Results: Median pre-surgical body mass index (BMI) was higher in adolescents (n = 76) vs. adults (n = 74): 50 (45–57) vs. 44 (40–51) kg/m(2) (p < 0.0001). However, obesity related complications were greater in adults vs. adolescents: 66 vs. 21% had hypertension, 68 vs. 28% had dyslipidemia, and 42 vs. 21% had type 2 diabetes mellitus (all p < 0.010). % BMI reduction and % weight loss (WL) were greater in adolescents vs. adults at all time points (p < 0.050). %WL was higher in adolescents who underwent SG at each time point (p < 0.050), and trended higher among adolescents who underwent RYGB (p = 0.060), compared to adults with the respective procedure. Follow-up data showed greater resolution of type 2 diabetes and hypertension in adolescents than adults (87.5 vs. 54.8%; p = 0.04, and 68.7 vs. 35.4%; p = 0.040). Conclusion: Adolescents compared to adults had greater reductions in BMI and weight, even at 4 years, and greater resolution of type 2 diabetes and hypertension. Earlier intervention in the treatment of severe obesity with MBS may lead to better outcomes.
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spelling pubmed-71057032020-04-07 Comparison of Short and Long-Term Outcomes of Metabolic and Bariatric Surgery in Adolescents and Adults Stanford, Fatima Cody Mushannen, Tasnim Cortez, Priscilla Campoverde Reyes, Karen J. Lee, Hang Gee, Denise W. Pratt, Janey S. Boepple, Paul A. Bredella, Miriam A. Misra, Madhusmita Singhal, Vibha Front Endocrinol (Lausanne) Endocrinology Objective: We sought to compare the short and long-term outcomes of MBS in adolescents vs. adults who have undergone a Roux-en-Y gastric bypass (RYGB) or Sleeve gastrectomy (SG). Design: Retrospective cohort study. Setting: Single tertiary care academic referral center. Participants: One hundred fifty adolescent (≤ 21-years) and adult (>21-years) subjects with severe obesity between 15 and 70 years of age who underwent RYGB or SG. Outcomes: Metabolic parameters, weight and height measures were obtained pre-and post-surgery (at 3 and 6 months, and then annually for 4 years). Results: Median pre-surgical body mass index (BMI) was higher in adolescents (n = 76) vs. adults (n = 74): 50 (45–57) vs. 44 (40–51) kg/m(2) (p < 0.0001). However, obesity related complications were greater in adults vs. adolescents: 66 vs. 21% had hypertension, 68 vs. 28% had dyslipidemia, and 42 vs. 21% had type 2 diabetes mellitus (all p < 0.010). % BMI reduction and % weight loss (WL) were greater in adolescents vs. adults at all time points (p < 0.050). %WL was higher in adolescents who underwent SG at each time point (p < 0.050), and trended higher among adolescents who underwent RYGB (p = 0.060), compared to adults with the respective procedure. Follow-up data showed greater resolution of type 2 diabetes and hypertension in adolescents than adults (87.5 vs. 54.8%; p = 0.04, and 68.7 vs. 35.4%; p = 0.040). Conclusion: Adolescents compared to adults had greater reductions in BMI and weight, even at 4 years, and greater resolution of type 2 diabetes and hypertension. Earlier intervention in the treatment of severe obesity with MBS may lead to better outcomes. Frontiers Media S.A. 2020-03-24 /pmc/articles/PMC7105703/ /pubmed/32265846 http://dx.doi.org/10.3389/fendo.2020.00157 Text en Copyright © 2020 Stanford, Mushannen, Cortez, Campoverde Reyes, Lee, Gee, Pratt, Boepple, Bredella, Misra and Singhal. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Stanford, Fatima Cody
Mushannen, Tasnim
Cortez, Priscilla
Campoverde Reyes, Karen J.
Lee, Hang
Gee, Denise W.
Pratt, Janey S.
Boepple, Paul A.
Bredella, Miriam A.
Misra, Madhusmita
Singhal, Vibha
Comparison of Short and Long-Term Outcomes of Metabolic and Bariatric Surgery in Adolescents and Adults
title Comparison of Short and Long-Term Outcomes of Metabolic and Bariatric Surgery in Adolescents and Adults
title_full Comparison of Short and Long-Term Outcomes of Metabolic and Bariatric Surgery in Adolescents and Adults
title_fullStr Comparison of Short and Long-Term Outcomes of Metabolic and Bariatric Surgery in Adolescents and Adults
title_full_unstemmed Comparison of Short and Long-Term Outcomes of Metabolic and Bariatric Surgery in Adolescents and Adults
title_short Comparison of Short and Long-Term Outcomes of Metabolic and Bariatric Surgery in Adolescents and Adults
title_sort comparison of short and long-term outcomes of metabolic and bariatric surgery in adolescents and adults
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7105703/
https://www.ncbi.nlm.nih.gov/pubmed/32265846
http://dx.doi.org/10.3389/fendo.2020.00157
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