The Emerging Roles of NDR1/2 in Infection and Inflammation

The nuclear Dbf2-related (NDR) kinases NDR1 and NDR2 belong to the NDR/LATS (large tumor suppressor) subfamily in the Hippo signaling pathway. They are highly conserved from yeast to humans. It is well-known that NDR1/2 control important cellular processes, such as morphological changes, centrosome...

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Autores principales: Ye, Xiaolan, Ong, Naomi, An, Huazhang, Zheng, Yuejuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7105721/
https://www.ncbi.nlm.nih.gov/pubmed/32265942
http://dx.doi.org/10.3389/fimmu.2020.00534
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author Ye, Xiaolan
Ong, Naomi
An, Huazhang
Zheng, Yuejuan
author_facet Ye, Xiaolan
Ong, Naomi
An, Huazhang
Zheng, Yuejuan
author_sort Ye, Xiaolan
collection PubMed
description The nuclear Dbf2-related (NDR) kinases NDR1 and NDR2 belong to the NDR/LATS (large tumor suppressor) subfamily in the Hippo signaling pathway. They are highly conserved from yeast to humans. It is well-known that NDR1/2 control important cellular processes, such as morphological changes, centrosome duplication, cell proliferation, and apoptosis. Recent studies revealed that NDR1/2 also play important roles in the regulation of infection and inflammation. In this review, we summarized the roles of NDR1/2 in the modulation of inflammation induced by cytokines and innate immune response against the infection of bacteria and viruses, emphasizing on how NDR1/2 regulate signaling transduction through Hippo pathway-dependent and -independent manners.
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spelling pubmed-71057212020-04-07 The Emerging Roles of NDR1/2 in Infection and Inflammation Ye, Xiaolan Ong, Naomi An, Huazhang Zheng, Yuejuan Front Immunol Immunology The nuclear Dbf2-related (NDR) kinases NDR1 and NDR2 belong to the NDR/LATS (large tumor suppressor) subfamily in the Hippo signaling pathway. They are highly conserved from yeast to humans. It is well-known that NDR1/2 control important cellular processes, such as morphological changes, centrosome duplication, cell proliferation, and apoptosis. Recent studies revealed that NDR1/2 also play important roles in the regulation of infection and inflammation. In this review, we summarized the roles of NDR1/2 in the modulation of inflammation induced by cytokines and innate immune response against the infection of bacteria and viruses, emphasizing on how NDR1/2 regulate signaling transduction through Hippo pathway-dependent and -independent manners. Frontiers Media S.A. 2020-03-24 /pmc/articles/PMC7105721/ /pubmed/32265942 http://dx.doi.org/10.3389/fimmu.2020.00534 Text en Copyright © 2020 Ye, Ong, An and Zheng. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Ye, Xiaolan
Ong, Naomi
An, Huazhang
Zheng, Yuejuan
The Emerging Roles of NDR1/2 in Infection and Inflammation
title The Emerging Roles of NDR1/2 in Infection and Inflammation
title_full The Emerging Roles of NDR1/2 in Infection and Inflammation
title_fullStr The Emerging Roles of NDR1/2 in Infection and Inflammation
title_full_unstemmed The Emerging Roles of NDR1/2 in Infection and Inflammation
title_short The Emerging Roles of NDR1/2 in Infection and Inflammation
title_sort emerging roles of ndr1/2 in infection and inflammation
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7105721/
https://www.ncbi.nlm.nih.gov/pubmed/32265942
http://dx.doi.org/10.3389/fimmu.2020.00534
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