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Gold Nanoclusters for Bacterial Detection and Infection Therapy

Infections caused by antibiotic-resistant bacteria have become one of the most serious global public health crises. Early detection and effective treatment can effectively prevent deterioration and further spreading of the bacterial infections. Therefore, there is an urgent need for time-saving diag...

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Autores principales: Tang, Mingxiu, Zhang, Jian, Yang, Chunyan, Zheng, Youkun, Jiang, Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7105725/
https://www.ncbi.nlm.nih.gov/pubmed/32266210
http://dx.doi.org/10.3389/fchem.2020.00181
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author Tang, Mingxiu
Zhang, Jian
Yang, Chunyan
Zheng, Youkun
Jiang, Hui
author_facet Tang, Mingxiu
Zhang, Jian
Yang, Chunyan
Zheng, Youkun
Jiang, Hui
author_sort Tang, Mingxiu
collection PubMed
description Infections caused by antibiotic-resistant bacteria have become one of the most serious global public health crises. Early detection and effective treatment can effectively prevent deterioration and further spreading of the bacterial infections. Therefore, there is an urgent need for time-saving diagnosis as well as therapeutically potent therapy approaches. Development of nanomedicine has provided more choices for detection and therapy of bacterial infections. Ultrasmall gold nanoclusters (Au NCs) are emerging as potential antibacterial agents and have drawn intense attention in the biomedical fields owing to their excellent biocompatibility and unusual physicochemical properties. Recent significant efforts have shown that these versatile Au NCs also have great application potential in the selective detection of bacteria and infection treatment. In this review, we will provide an overview of research progress on the development of versatile Au NCs for bacterial detection and infection treatment, and the mechanisms of action of designed diagnostic and therapeutic agents will be highlighted. Based on these cases, we have briefly discussed the current issues and perspective of Au NCs for bacterial detection and infection treatment applications.
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spelling pubmed-71057252020-04-07 Gold Nanoclusters for Bacterial Detection and Infection Therapy Tang, Mingxiu Zhang, Jian Yang, Chunyan Zheng, Youkun Jiang, Hui Front Chem Chemistry Infections caused by antibiotic-resistant bacteria have become one of the most serious global public health crises. Early detection and effective treatment can effectively prevent deterioration and further spreading of the bacterial infections. Therefore, there is an urgent need for time-saving diagnosis as well as therapeutically potent therapy approaches. Development of nanomedicine has provided more choices for detection and therapy of bacterial infections. Ultrasmall gold nanoclusters (Au NCs) are emerging as potential antibacterial agents and have drawn intense attention in the biomedical fields owing to their excellent biocompatibility and unusual physicochemical properties. Recent significant efforts have shown that these versatile Au NCs also have great application potential in the selective detection of bacteria and infection treatment. In this review, we will provide an overview of research progress on the development of versatile Au NCs for bacterial detection and infection treatment, and the mechanisms of action of designed diagnostic and therapeutic agents will be highlighted. Based on these cases, we have briefly discussed the current issues and perspective of Au NCs for bacterial detection and infection treatment applications. Frontiers Media S.A. 2020-03-24 /pmc/articles/PMC7105725/ /pubmed/32266210 http://dx.doi.org/10.3389/fchem.2020.00181 Text en Copyright © 2020 Tang, Zhang, Yang, Zheng and Jiang. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Chemistry
Tang, Mingxiu
Zhang, Jian
Yang, Chunyan
Zheng, Youkun
Jiang, Hui
Gold Nanoclusters for Bacterial Detection and Infection Therapy
title Gold Nanoclusters for Bacterial Detection and Infection Therapy
title_full Gold Nanoclusters for Bacterial Detection and Infection Therapy
title_fullStr Gold Nanoclusters for Bacterial Detection and Infection Therapy
title_full_unstemmed Gold Nanoclusters for Bacterial Detection and Infection Therapy
title_short Gold Nanoclusters for Bacterial Detection and Infection Therapy
title_sort gold nanoclusters for bacterial detection and infection therapy
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7105725/
https://www.ncbi.nlm.nih.gov/pubmed/32266210
http://dx.doi.org/10.3389/fchem.2020.00181
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