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In silico Design of Novel HIV-1 NNRTIs Based on Combined Modeling Studies of Dihydrofuro[3,4-d]pyrimidines

A novel series of dihydrofuro[3,4-d]pyrimidine (DHPY) analogs have recently been recognized as promising HIV-1 non-nucleoside reverse transcriptase (RT) inhibitors (NNRTIs) with potent antiviral activity. To better understand the pharmacological essentiality of these DHPYs and design novel NNRTI lea...

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Detalles Bibliográficos
Autores principales:	Chen, Yanming, Tian, Yafeng, Gao, Ya, Wu, Fengshou, Luo, Xiaogang, Ju, Xiulian, Liu, Genyan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7105726/ https://www.ncbi.nlm.nih.gov/pubmed/32266208 http://dx.doi.org/10.3389/fchem.2020.00164

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