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Active transport of rhodamine 123 by the human multidrug transporter P‐glycoprotein involves two independent outer gates

Human P‐glycoprotein (P‐gp) is a multispecific drug‐efflux transporter, which plays an important role in drug resistance and drug disposition. Recent cryo‐electron microscopy structures confirmed its rotationally symmetric architecture, which allows dual interaction with ATP and substrates. We here...

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Detalles Bibliográficos
Autores principales:	Nasim, Fauzia, Schmid, Diethart, Szakács, Gergely, Sohail, Azmat, Sitte, Harald H., Chiba, Peter, Stockner, Thomas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2020
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7105846/ https://www.ncbi.nlm.nih.gov/pubmed/32232949 http://dx.doi.org/10.1002/prp2.572

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