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Locked nucleic acid (LNA): High affinity targeting of RNA for diagnostics and therapeutics

Locked nucleic acid (LNA) is a nucleic acid analogue containing one or more LNA nucleotide monomers with a bicyclic furanose unit locked in an RNA mimicking sugar conformation. This conformational restriction results in unprecedented hybridization affinity towards complementary single stranded RNA a...

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Detalles Bibliográficos
Autores principales:	Kauppinen, Sakari, Vester, Birte, Wengel, Jesper
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier Ltd. 2005
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7105916/ https://www.ncbi.nlm.nih.gov/pubmed/24981949 http://dx.doi.org/10.1016/j.ddtec.2005.08.012

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