The renin–angiotensin system in acute respiratory distress syndrome

Angiotensin-converting enzyme 2 (ACE2) counterbalances with ACE and functions as a negative regulator of the renin–angiotensin system (RAS). The importance of RAS in acute respiratory distress syndrome (ARDS) has recently re-emerged owing to the identification of ACE2 as a receptor for the SARS-coro...

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Detalles Bibliográficos
Autores principales: Imai, Yumiko, Kuba, Keiji, Penninger, Josef M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2006
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7105919/
https://www.ncbi.nlm.nih.gov/pubmed/32288774
http://dx.doi.org/10.1016/j.ddmec.2006.06.012
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author Imai, Yumiko
Kuba, Keiji
Penninger, Josef M.
author_facet Imai, Yumiko
Kuba, Keiji
Penninger, Josef M.
author_sort Imai, Yumiko
collection PubMed
description Angiotensin-converting enzyme 2 (ACE2) counterbalances with ACE and functions as a negative regulator of the renin–angiotensin system (RAS). The importance of RAS in acute respiratory distress syndrome (ARDS) has recently re-emerged owing to the identification of ACE2 as a receptor for the SARS-coronavirus. Recent studies have demonstrated that ACE2 protects mice from acute lung injury as well as SARS-mediated lung injury. We review the role of the RAS, in particular ACE2, in the pathogenesis of ARDS.
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spelling pubmed-71059192020-03-31 The renin–angiotensin system in acute respiratory distress syndrome Imai, Yumiko Kuba, Keiji Penninger, Josef M. Drug Discov Today Dis Mech Article Angiotensin-converting enzyme 2 (ACE2) counterbalances with ACE and functions as a negative regulator of the renin–angiotensin system (RAS). The importance of RAS in acute respiratory distress syndrome (ARDS) has recently re-emerged owing to the identification of ACE2 as a receptor for the SARS-coronavirus. Recent studies have demonstrated that ACE2 protects mice from acute lung injury as well as SARS-mediated lung injury. We review the role of the RAS, in particular ACE2, in the pathogenesis of ARDS. Elsevier Ltd. 2006 2006-08-07 /pmc/articles/PMC7105919/ /pubmed/32288774 http://dx.doi.org/10.1016/j.ddmec.2006.06.012 Text en Copyright © 2006 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Imai, Yumiko
Kuba, Keiji
Penninger, Josef M.
The renin–angiotensin system in acute respiratory distress syndrome
title The renin–angiotensin system in acute respiratory distress syndrome
title_full The renin–angiotensin system in acute respiratory distress syndrome
title_fullStr The renin–angiotensin system in acute respiratory distress syndrome
title_full_unstemmed The renin–angiotensin system in acute respiratory distress syndrome
title_short The renin–angiotensin system in acute respiratory distress syndrome
title_sort renin–angiotensin system in acute respiratory distress syndrome
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7105919/
https://www.ncbi.nlm.nih.gov/pubmed/32288774
http://dx.doi.org/10.1016/j.ddmec.2006.06.012
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