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Nsp1 proteins of group I and SARS coronaviruses share structural and functional similarities

The nsp1 protein of the highly pathogenic SARS coronavirus suppresses host protein synthesis, including genes involved in the innate immune system. A bioinformatic analysis revealed that the nsp1 proteins of group I and SARS coronaviruses have similar structures. Nsp1 proteins of group I coronavirus...

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Autores principales: Wang, Yongjin, Shi, Huiling, Rigolet, Pascal, Wu, Nannan, Zhu, Lichen, Xi, Xu-Guang, Vabret, Astrid, Wang, Xiaoming, Wang, Tianhou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7106014/
https://www.ncbi.nlm.nih.gov/pubmed/20609418
http://dx.doi.org/10.1016/j.meegid.2010.05.014
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author Wang, Yongjin
Shi, Huiling
Rigolet, Pascal
Wu, Nannan
Zhu, Lichen
Xi, Xu-Guang
Vabret, Astrid
Wang, Xiaoming
Wang, Tianhou
author_facet Wang, Yongjin
Shi, Huiling
Rigolet, Pascal
Wu, Nannan
Zhu, Lichen
Xi, Xu-Guang
Vabret, Astrid
Wang, Xiaoming
Wang, Tianhou
author_sort Wang, Yongjin
collection PubMed
description The nsp1 protein of the highly pathogenic SARS coronavirus suppresses host protein synthesis, including genes involved in the innate immune system. A bioinformatic analysis revealed that the nsp1 proteins of group I and SARS coronaviruses have similar structures. Nsp1 proteins of group I coronaviruses interacted with host ribosomal 40S subunit and did not inhibit IRF-3 activation. However, synthesis of host immune and non-immune proteins was inhibited by nsp1 proteins at both transcriptional and translational levels, similar to SARS coronavirus nsp1. These results indicate that different coronaviruses might employ the same nsp1 mechanism to antagonize host innate immunity and cell proliferation. However, nsp1 may not be the key determinant of viral pathogenicity, or the factor used by the SARS coronavirus to evade host innate immunity.
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spelling pubmed-71060142020-03-31 Nsp1 proteins of group I and SARS coronaviruses share structural and functional similarities Wang, Yongjin Shi, Huiling Rigolet, Pascal Wu, Nannan Zhu, Lichen Xi, Xu-Guang Vabret, Astrid Wang, Xiaoming Wang, Tianhou Infect Genet Evol Article The nsp1 protein of the highly pathogenic SARS coronavirus suppresses host protein synthesis, including genes involved in the innate immune system. A bioinformatic analysis revealed that the nsp1 proteins of group I and SARS coronaviruses have similar structures. Nsp1 proteins of group I coronaviruses interacted with host ribosomal 40S subunit and did not inhibit IRF-3 activation. However, synthesis of host immune and non-immune proteins was inhibited by nsp1 proteins at both transcriptional and translational levels, similar to SARS coronavirus nsp1. These results indicate that different coronaviruses might employ the same nsp1 mechanism to antagonize host innate immunity and cell proliferation. However, nsp1 may not be the key determinant of viral pathogenicity, or the factor used by the SARS coronavirus to evade host innate immunity. Elsevier B.V. 2010-10 2010-06-02 /pmc/articles/PMC7106014/ /pubmed/20609418 http://dx.doi.org/10.1016/j.meegid.2010.05.014 Text en Copyright © 2010 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Wang, Yongjin
Shi, Huiling
Rigolet, Pascal
Wu, Nannan
Zhu, Lichen
Xi, Xu-Guang
Vabret, Astrid
Wang, Xiaoming
Wang, Tianhou
Nsp1 proteins of group I and SARS coronaviruses share structural and functional similarities
title Nsp1 proteins of group I and SARS coronaviruses share structural and functional similarities
title_full Nsp1 proteins of group I and SARS coronaviruses share structural and functional similarities
title_fullStr Nsp1 proteins of group I and SARS coronaviruses share structural and functional similarities
title_full_unstemmed Nsp1 proteins of group I and SARS coronaviruses share structural and functional similarities
title_short Nsp1 proteins of group I and SARS coronaviruses share structural and functional similarities
title_sort nsp1 proteins of group i and sars coronaviruses share structural and functional similarities
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7106014/
https://www.ncbi.nlm.nih.gov/pubmed/20609418
http://dx.doi.org/10.1016/j.meegid.2010.05.014
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