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Inhibition of infection caused by severe acute respiratory syndrome-associated coronavirus by equine neutralizing antibody in aged mice()
The high susceptibility of elderly to severe acute respiratory syndrome-associated coronavirus (SARS-CoV) indicates how crucial it is to protect the elderly by various strategies. Aged BALB/c mice displayed a high susceptibility to SARS-CoV and have been a valuable platform for evaluation of strateg...
| Autores principales: | , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier B.V.
2007
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7106264/ https://www.ncbi.nlm.nih.gov/pubmed/17276898 http://dx.doi.org/10.1016/j.intimp.2006.10.009 |
| _version_ | 1783512577953759232 |
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| author | Zhou, Lili Ni, Bing Luo, Deyan Zhao, Guangyu Jia, Zhengcai Zhang, Liangyan Lin, Zhihua Wang, Li Zhang, Songle Xing, Li Li, Jintao Liang, Yunfei Shi, Xinfu Zhao, TingTing Zhou, Liyun Wu, Yuzhang Wang, Xiliang |
| author_facet | Zhou, Lili Ni, Bing Luo, Deyan Zhao, Guangyu Jia, Zhengcai Zhang, Liangyan Lin, Zhihua Wang, Li Zhang, Songle Xing, Li Li, Jintao Liang, Yunfei Shi, Xinfu Zhao, TingTing Zhou, Liyun Wu, Yuzhang Wang, Xiliang |
| author_sort | Zhou, Lili |
| collection | PubMed |
| description | The high susceptibility of elderly to severe acute respiratory syndrome-associated coronavirus (SARS-CoV) indicates how crucial it is to protect the elderly by various strategies. Aged BALB/c mice displayed a high susceptibility to SARS-CoV and have been a valuable platform for evaluation of strategies against SARS-CoV infection. In this study, we confirmed the validity of this model using various methods, and verified that equine anti-SARS-CoV F(ab')(2) can prevent aged animals from SARS-CoV infection. In a therapeutic setting, treatment with anti-SARS-CoV F(ab')(2) decreased viral load more than several thousand folds in the lungs. Thus, this antibody should be a potential candidate for treatment of elderly patients suffering from SARS. |
| format | Online Article Text |
| id | pubmed-7106264 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2007 |
| publisher | Elsevier B.V. |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-71062642020-03-31 Inhibition of infection caused by severe acute respiratory syndrome-associated coronavirus by equine neutralizing antibody in aged mice() Zhou, Lili Ni, Bing Luo, Deyan Zhao, Guangyu Jia, Zhengcai Zhang, Liangyan Lin, Zhihua Wang, Li Zhang, Songle Xing, Li Li, Jintao Liang, Yunfei Shi, Xinfu Zhao, TingTing Zhou, Liyun Wu, Yuzhang Wang, Xiliang Int Immunopharmacol Article The high susceptibility of elderly to severe acute respiratory syndrome-associated coronavirus (SARS-CoV) indicates how crucial it is to protect the elderly by various strategies. Aged BALB/c mice displayed a high susceptibility to SARS-CoV and have been a valuable platform for evaluation of strategies against SARS-CoV infection. In this study, we confirmed the validity of this model using various methods, and verified that equine anti-SARS-CoV F(ab')(2) can prevent aged animals from SARS-CoV infection. In a therapeutic setting, treatment with anti-SARS-CoV F(ab')(2) decreased viral load more than several thousand folds in the lungs. Thus, this antibody should be a potential candidate for treatment of elderly patients suffering from SARS. Elsevier B.V. 2007-03 2006-11-27 /pmc/articles/PMC7106264/ /pubmed/17276898 http://dx.doi.org/10.1016/j.intimp.2006.10.009 Text en Copyright © 2006 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
| spellingShingle | Article Zhou, Lili Ni, Bing Luo, Deyan Zhao, Guangyu Jia, Zhengcai Zhang, Liangyan Lin, Zhihua Wang, Li Zhang, Songle Xing, Li Li, Jintao Liang, Yunfei Shi, Xinfu Zhao, TingTing Zhou, Liyun Wu, Yuzhang Wang, Xiliang Inhibition of infection caused by severe acute respiratory syndrome-associated coronavirus by equine neutralizing antibody in aged mice() |
| title | Inhibition of infection caused by severe acute respiratory syndrome-associated coronavirus by equine neutralizing antibody in aged mice() |
| title_full | Inhibition of infection caused by severe acute respiratory syndrome-associated coronavirus by equine neutralizing antibody in aged mice() |
| title_fullStr | Inhibition of infection caused by severe acute respiratory syndrome-associated coronavirus by equine neutralizing antibody in aged mice() |
| title_full_unstemmed | Inhibition of infection caused by severe acute respiratory syndrome-associated coronavirus by equine neutralizing antibody in aged mice() |
| title_short | Inhibition of infection caused by severe acute respiratory syndrome-associated coronavirus by equine neutralizing antibody in aged mice() |
| title_sort | inhibition of infection caused by severe acute respiratory syndrome-associated coronavirus by equine neutralizing antibody in aged mice() |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7106264/ https://www.ncbi.nlm.nih.gov/pubmed/17276898 http://dx.doi.org/10.1016/j.intimp.2006.10.009 |
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