p53 Acts as a Safeguard of Translational Control by Regulating Fibrillarin and rRNA Methylation in Cancer

Ribosomes are specialized entities that participate in regulation of gene expression through their rRNAs carrying ribozyme activity. Ribosome biogenesis is overactivated in p53-inactivated cancer cells, although involvement of p53 on ribosome quality is unknown. Here, we show that p53 represses expr...

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Detalles Bibliográficos
Autores principales: Marcel, Virginie, Ghayad, Sandra E., Belin, Stéphane, Therizols, Gabriel, Morel, Anne-Pierre, Solano-Gonzàlez, Eduardo, Vendrell, Julie A., Hacot, Sabine, Mertani, Hichem C., Albaret, Marie Alexandra, Bourdon, Jean-Christophe, Jordan, Lee, Thompson, Alastair, Tafer, Yasmine, Cong, Rong, Bouvet, Philippe, Saurin, Jean-Christophe, Catez, Frédéric, Prats, Anne-Catherine, Puisieux, Alain, Diaz, Jean-Jacques
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7106277/
https://www.ncbi.nlm.nih.gov/pubmed/24029231
http://dx.doi.org/10.1016/j.ccr.2013.08.013

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