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Human metapneumovirus in paediatric intensive care unit (PICU) admissions in the United Kingdom (UK) 2006–2014
BACKGROUND: Human metapneumovirus (HMPV) is a pneumovirus known to cause respiratory disease in children. It was identified as a pathogen in 2001 and its healthcare burden and associated costs are not fully understood. OBJECTIVES: This study aimed to assess the clinical characteristics of children w...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier B.V.
2019
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7106375/ https://www.ncbi.nlm.nih.gov/pubmed/30669024 http://dx.doi.org/10.1016/j.jcv.2019.01.006 |
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author | Barr, Rachael McGalliard, Rachel Drysdale, Simon B |
author_facet | Barr, Rachael McGalliard, Rachel Drysdale, Simon B |
author_sort | Barr, Rachael |
collection | PubMed |
description | BACKGROUND: Human metapneumovirus (HMPV) is a pneumovirus known to cause respiratory disease in children. It was identified as a pathogen in 2001 and its healthcare burden and associated costs are not fully understood. OBJECTIVES: This study aimed to assess the clinical characteristics of children with HMPV infection admitted to paediatric intensive care units (PICUs) across the United Kingdom (UK) over a nine-year period and to estimate the associated costs of care. STUDY DESIGN: Data were collected from the UK paediatric intensive care audit network (PICANet) and costs calculated using the National Health Service (NHS) reference costing scheme. RESULTS: There were 114 admissions in which HMPV was detected. The number of admissions associated with a code of HMPV rose steadily over the study period (three in 2006 to 28 in 2014) and showed significant seasonal variability, with the peak season being from November to May. Children required varying levels of intensive care support from minimal to complex support including invasive ventilation, inotropes, renal replacement therapy and extracorporeal membrane oxygenation (ECMO). HMPV was associated with five deaths during the study period. The associated costs of PICU admissions were estimated to be between £2,256,823 and £3,997,823 over the study period, with estimated annual costs rising over the study period due to increasing HMPV admissions. CONCLUSIONS: HMPV is associated with a significant healthcare burden and associated cost of care in PICUs in the UK. |
format | Online Article Text |
id | pubmed-7106375 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Elsevier B.V. |
record_format | MEDLINE/PubMed |
spelling | pubmed-71063752020-03-31 Human metapneumovirus in paediatric intensive care unit (PICU) admissions in the United Kingdom (UK) 2006–2014 Barr, Rachael McGalliard, Rachel Drysdale, Simon B J Clin Virol Article BACKGROUND: Human metapneumovirus (HMPV) is a pneumovirus known to cause respiratory disease in children. It was identified as a pathogen in 2001 and its healthcare burden and associated costs are not fully understood. OBJECTIVES: This study aimed to assess the clinical characteristics of children with HMPV infection admitted to paediatric intensive care units (PICUs) across the United Kingdom (UK) over a nine-year period and to estimate the associated costs of care. STUDY DESIGN: Data were collected from the UK paediatric intensive care audit network (PICANet) and costs calculated using the National Health Service (NHS) reference costing scheme. RESULTS: There were 114 admissions in which HMPV was detected. The number of admissions associated with a code of HMPV rose steadily over the study period (three in 2006 to 28 in 2014) and showed significant seasonal variability, with the peak season being from November to May. Children required varying levels of intensive care support from minimal to complex support including invasive ventilation, inotropes, renal replacement therapy and extracorporeal membrane oxygenation (ECMO). HMPV was associated with five deaths during the study period. The associated costs of PICU admissions were estimated to be between £2,256,823 and £3,997,823 over the study period, with estimated annual costs rising over the study period due to increasing HMPV admissions. CONCLUSIONS: HMPV is associated with a significant healthcare burden and associated cost of care in PICUs in the UK. Elsevier B.V. 2019-03 2019-01-16 /pmc/articles/PMC7106375/ /pubmed/30669024 http://dx.doi.org/10.1016/j.jcv.2019.01.006 Text en © 2019 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Barr, Rachael McGalliard, Rachel Drysdale, Simon B Human metapneumovirus in paediatric intensive care unit (PICU) admissions in the United Kingdom (UK) 2006–2014 |
title | Human metapneumovirus in paediatric intensive care unit (PICU) admissions in the United Kingdom (UK) 2006–2014 |
title_full | Human metapneumovirus in paediatric intensive care unit (PICU) admissions in the United Kingdom (UK) 2006–2014 |
title_fullStr | Human metapneumovirus in paediatric intensive care unit (PICU) admissions in the United Kingdom (UK) 2006–2014 |
title_full_unstemmed | Human metapneumovirus in paediatric intensive care unit (PICU) admissions in the United Kingdom (UK) 2006–2014 |
title_short | Human metapneumovirus in paediatric intensive care unit (PICU) admissions in the United Kingdom (UK) 2006–2014 |
title_sort | human metapneumovirus in paediatric intensive care unit (picu) admissions in the united kingdom (uk) 2006–2014 |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7106375/ https://www.ncbi.nlm.nih.gov/pubmed/30669024 http://dx.doi.org/10.1016/j.jcv.2019.01.006 |
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