siRNA and the lung: research tool or therapeutic drug?

Oligonucleotide-based therapeutics have been hailed as ‘the next great wave of the biotechnology revolution’ starting with antisense oligonucleotides (ASOs) nearly 20 years ago to RNA interference (RNAi) currently. Is RNAi just the latest research tool or does it have real potential as a therapeutic...

Descripción completa

Detalles Bibliográficos
Autores principales: de Fougerolles, Antonin, Novobrantseva, Tatiana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2008
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7106383/
https://www.ncbi.nlm.nih.gov/pubmed/18485820
http://dx.doi.org/10.1016/j.coph.2008.04.005
_version_ 1783512598322348032
author de Fougerolles, Antonin
Novobrantseva, Tatiana
author_facet de Fougerolles, Antonin
Novobrantseva, Tatiana
author_sort de Fougerolles, Antonin
collection PubMed
description Oligonucleotide-based therapeutics have been hailed as ‘the next great wave of the biotechnology revolution’ starting with antisense oligonucleotides (ASOs) nearly 20 years ago to RNA interference (RNAi) currently. Is RNAi just the latest research tool or does it have real potential as a therapeutic drug modality? As a research tool, it is evident that RNAi has revolutionized the biological sciences by allowing selective silencing of messenger RNA (mRNA) expression. With the advent of the postgenomic era, RNAi offers a therapeutic platform on which to identify potential picomolar active drug candidates to any target, including those that are conventionally undruggable. In this review, we will discuss the progress made in developing RNAi therapeutics for the treatment of respiratory diseases.
format Online
Article
Text
id pubmed-7106383
institution National Center for Biotechnology Information
language English
publishDate 2008
publisher Elsevier Ltd.
record_format MEDLINE/PubMed
spelling pubmed-71063832020-03-31 siRNA and the lung: research tool or therapeutic drug? de Fougerolles, Antonin Novobrantseva, Tatiana Curr Opin Pharmacol Article Oligonucleotide-based therapeutics have been hailed as ‘the next great wave of the biotechnology revolution’ starting with antisense oligonucleotides (ASOs) nearly 20 years ago to RNA interference (RNAi) currently. Is RNAi just the latest research tool or does it have real potential as a therapeutic drug modality? As a research tool, it is evident that RNAi has revolutionized the biological sciences by allowing selective silencing of messenger RNA (mRNA) expression. With the advent of the postgenomic era, RNAi offers a therapeutic platform on which to identify potential picomolar active drug candidates to any target, including those that are conventionally undruggable. In this review, we will discuss the progress made in developing RNAi therapeutics for the treatment of respiratory diseases. Elsevier Ltd. 2008-06 2008-05-14 /pmc/articles/PMC7106383/ /pubmed/18485820 http://dx.doi.org/10.1016/j.coph.2008.04.005 Text en Copyright © 2008 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
de Fougerolles, Antonin
Novobrantseva, Tatiana
siRNA and the lung: research tool or therapeutic drug?
title siRNA and the lung: research tool or therapeutic drug?
title_full siRNA and the lung: research tool or therapeutic drug?
title_fullStr siRNA and the lung: research tool or therapeutic drug?
title_full_unstemmed siRNA and the lung: research tool or therapeutic drug?
title_short siRNA and the lung: research tool or therapeutic drug?
title_sort sirna and the lung: research tool or therapeutic drug?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7106383/
https://www.ncbi.nlm.nih.gov/pubmed/18485820
http://dx.doi.org/10.1016/j.coph.2008.04.005
work_keys_str_mv AT defougerollesantonin sirnaandthelungresearchtoolortherapeuticdrug
AT novobrantsevatatiana sirnaandthelungresearchtoolortherapeuticdrug

Ejemplares similares