Tertiary lymphoid organs in infection and autoimmunity

The lymph nodes (LNs) and spleen have an optimal structure that allows the interaction between T cells, B cells and antigen-presenting dendritic cells (DCs) on a matrix made up by stromal cells. Such a highly organized structure can also be formed in tertiary lymphoid organs (TLOs) at sites of infec...

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Detalles Bibliográficos
Autores principales: Neyt, Katrijn, Perros, Frédéric, GeurtsvanKessel, Corine H., Hammad, Hamida, Lambrecht, Bart N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7106385/
https://www.ncbi.nlm.nih.gov/pubmed/22622061
http://dx.doi.org/10.1016/j.it.2012.04.006
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author Neyt, Katrijn
Perros, Frédéric
GeurtsvanKessel, Corine H.
Hammad, Hamida
Lambrecht, Bart N.
author_facet Neyt, Katrijn
Perros, Frédéric
GeurtsvanKessel, Corine H.
Hammad, Hamida
Lambrecht, Bart N.
author_sort Neyt, Katrijn
collection PubMed
description The lymph nodes (LNs) and spleen have an optimal structure that allows the interaction between T cells, B cells and antigen-presenting dendritic cells (DCs) on a matrix made up by stromal cells. Such a highly organized structure can also be formed in tertiary lymphoid organs (TLOs) at sites of infection or chronic immune stimulation. This review focuses on the molecular mechanisms of TLO formation and maintenance, the controversies surrounding the nature of the inducing events, and the functions of these structures in infection, transplantation and autoimmunity.
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spelling pubmed-71063852020-03-31 Tertiary lymphoid organs in infection and autoimmunity Neyt, Katrijn Perros, Frédéric GeurtsvanKessel, Corine H. Hammad, Hamida Lambrecht, Bart N. Trends Immunol Article The lymph nodes (LNs) and spleen have an optimal structure that allows the interaction between T cells, B cells and antigen-presenting dendritic cells (DCs) on a matrix made up by stromal cells. Such a highly organized structure can also be formed in tertiary lymphoid organs (TLOs) at sites of infection or chronic immune stimulation. This review focuses on the molecular mechanisms of TLO formation and maintenance, the controversies surrounding the nature of the inducing events, and the functions of these structures in infection, transplantation and autoimmunity. Elsevier Ltd. 2012-06 2012-05-21 /pmc/articles/PMC7106385/ /pubmed/22622061 http://dx.doi.org/10.1016/j.it.2012.04.006 Text en Copyright © 2012 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Neyt, Katrijn
Perros, Frédéric
GeurtsvanKessel, Corine H.
Hammad, Hamida
Lambrecht, Bart N.
Tertiary lymphoid organs in infection and autoimmunity
title Tertiary lymphoid organs in infection and autoimmunity
title_full Tertiary lymphoid organs in infection and autoimmunity
title_fullStr Tertiary lymphoid organs in infection and autoimmunity
title_full_unstemmed Tertiary lymphoid organs in infection and autoimmunity
title_short Tertiary lymphoid organs in infection and autoimmunity
title_sort tertiary lymphoid organs in infection and autoimmunity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7106385/
https://www.ncbi.nlm.nih.gov/pubmed/22622061
http://dx.doi.org/10.1016/j.it.2012.04.006
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