Tumoricidal activity of human dendritic cells

Dendritic cells (DCs) are a family of professional antigen-presenting cells (APCs) that are able to initiate innate and adaptive immune responses against pathogens and tumor cells. The DC family is heterogeneous and is classically divided into two main subsets, each with its unique phenotypic and fu...

Descripción completa

Detalles Bibliográficos
Autores principales: Tel, Jurjen, Anguille, Sébastien, Waterborg, Claire E.J., Smits, Evelien L., Figdor, Carl G., de Vries, I. Jolanda M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7106406/
https://www.ncbi.nlm.nih.gov/pubmed/24262387
http://dx.doi.org/10.1016/j.it.2013.10.007
_version_ 1783512602107707392
author Tel, Jurjen
Anguille, Sébastien
Waterborg, Claire E.J.
Smits, Evelien L.
Figdor, Carl G.
de Vries, I. Jolanda M.
author_facet Tel, Jurjen
Anguille, Sébastien
Waterborg, Claire E.J.
Smits, Evelien L.
Figdor, Carl G.
de Vries, I. Jolanda M.
author_sort Tel, Jurjen
collection PubMed
description Dendritic cells (DCs) are a family of professional antigen-presenting cells (APCs) that are able to initiate innate and adaptive immune responses against pathogens and tumor cells. The DC family is heterogeneous and is classically divided into two main subsets, each with its unique phenotypic and functional characteristics: myeloid DCs (mDCs) and plasmacytoid DCs (pDCs). Recent results have provided intriguing evidence that both DC subsets can also function as direct cytotoxic effector cells; in particular, against cancer cells. In this review, we delve into this understudied function of human DCs and discuss why these so-called killer DCs might become important tools in future cancer immunotherapies.
format Online
Article
Text
id pubmed-7106406
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Elsevier Ltd.
record_format MEDLINE/PubMed
spelling pubmed-71064062020-03-31 Tumoricidal activity of human dendritic cells Tel, Jurjen Anguille, Sébastien Waterborg, Claire E.J. Smits, Evelien L. Figdor, Carl G. de Vries, I. Jolanda M. Trends Immunol Article Dendritic cells (DCs) are a family of professional antigen-presenting cells (APCs) that are able to initiate innate and adaptive immune responses against pathogens and tumor cells. The DC family is heterogeneous and is classically divided into two main subsets, each with its unique phenotypic and functional characteristics: myeloid DCs (mDCs) and plasmacytoid DCs (pDCs). Recent results have provided intriguing evidence that both DC subsets can also function as direct cytotoxic effector cells; in particular, against cancer cells. In this review, we delve into this understudied function of human DCs and discuss why these so-called killer DCs might become important tools in future cancer immunotherapies. Elsevier Ltd. 2014-01 2013-11-18 /pmc/articles/PMC7106406/ /pubmed/24262387 http://dx.doi.org/10.1016/j.it.2013.10.007 Text en Copyright © 2013 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Tel, Jurjen
Anguille, Sébastien
Waterborg, Claire E.J.
Smits, Evelien L.
Figdor, Carl G.
de Vries, I. Jolanda M.
Tumoricidal activity of human dendritic cells
title Tumoricidal activity of human dendritic cells
title_full Tumoricidal activity of human dendritic cells
title_fullStr Tumoricidal activity of human dendritic cells
title_full_unstemmed Tumoricidal activity of human dendritic cells
title_short Tumoricidal activity of human dendritic cells
title_sort tumoricidal activity of human dendritic cells
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7106406/
https://www.ncbi.nlm.nih.gov/pubmed/24262387
http://dx.doi.org/10.1016/j.it.2013.10.007
work_keys_str_mv AT teljurjen tumoricidalactivityofhumandendriticcells
AT anguillesebastien tumoricidalactivityofhumandendriticcells
AT waterborgclaireej tumoricidalactivityofhumandendriticcells
AT smitsevelienl tumoricidalactivityofhumandendriticcells
AT figdorcarlg tumoricidalactivityofhumandendriticcells
AT devriesijolandam tumoricidalactivityofhumandendriticcells

Ejemplares similares