Design, Synthesis and Discovery of N,N’‐Carbazoyl‐aryl‐urea Inhibitors of Zika NS5 Methyltransferase and Virus Replication

The recent outbreaks of Zika virus (ZIKV) infection worldwide make the discovery of novel antivirals against flaviviruses a research priority. This work describes the identification of novel inhibitors of ZIKV through a structure‐based virtual screening approach using the ZIKV NS5‐MTase. A novel ser...

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Detalles Bibliográficos
Autores principales: Spizzichino, Sharon, Mattedi, Giulio, Lauder, Kate, Valle, Coralie, Aouadi, Wahiba, Canard, Bruno, Decroly, Etienne, Kaptein, Suzanne J. F., Neyts, Johan, Graham, Carl, Sule, Zakary, Barlow, David J., Silvestri, Romano, Castagnolo, Daniele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7106487/
https://www.ncbi.nlm.nih.gov/pubmed/31805205
http://dx.doi.org/10.1002/cmdc.201900533

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