Cargando…

Impact of respiratory viruses in hospital-acquired pneumonia in the intensive care unit: A single-center retrospective study

BACKGROUND: Data on the frequency and role of respiratory viruses (RVs) in hospital-acquired pneumonia (HAP) are still scarce. OBJECTIVES: We assessed the proportion of RVs and their impact on the outcome of hospital-acquired pneumonia (HAP) in the intensive care unit (ICU). STUDY DESIGN: Cases of H...

Descripción completa

Detalles Bibliográficos
Autores principales: Loubet, Paul, Voiriot, Guillaume, Houhou-Fidouh, Nadhira, Neuville, Mathilde, Bouadma, Lila, Lescure, Francois-Xavier, Descamps, Diane, Timsit, Jean-François, Yazdanpanah, Yazdan, Visseaux, Benoit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7106511/
https://www.ncbi.nlm.nih.gov/pubmed/28494435
http://dx.doi.org/10.1016/j.jcv.2017.04.001
_version_ 1783512620677988352
author Loubet, Paul
Voiriot, Guillaume
Houhou-Fidouh, Nadhira
Neuville, Mathilde
Bouadma, Lila
Lescure, Francois-Xavier
Descamps, Diane
Timsit, Jean-François
Yazdanpanah, Yazdan
Visseaux, Benoit
author_facet Loubet, Paul
Voiriot, Guillaume
Houhou-Fidouh, Nadhira
Neuville, Mathilde
Bouadma, Lila
Lescure, Francois-Xavier
Descamps, Diane
Timsit, Jean-François
Yazdanpanah, Yazdan
Visseaux, Benoit
author_sort Loubet, Paul
collection PubMed
description BACKGROUND: Data on the frequency and role of respiratory viruses (RVs) in hospital-acquired pneumonia (HAP) are still scarce. OBJECTIVES: We assessed the proportion of RVs and their impact on the outcome of hospital-acquired pneumonia (HAP) in the intensive care unit (ICU). STUDY DESIGN: Cases of HAP were retrospectively selected among patients who underwent screening for RVs by multiplex PCR (mPCR) in the ICU of a French tertiary care hospital from May 2014 to April 2016. ICU length of stay and in-hospital mortality were compared between four groups defined according to the identified pathogens: virus only (V), virus/bacteria (V/B), bacteria only (B) and no pathogen (Neg). When available, previous mPCR was retrieved in order to assess possible chronic viral carriage. RESULTS: Overall, 95/999 (10%) ICU patients who underwent mPCR had HAP (V(17,18%), V/B(13,14%), B(60,63%), Neg(5,5%)). Median age was 61 years and 45 (47%) were immunocompromised. Influenza (27%) and rhinovirus (27%) were the most common RVs. V/B group had higher mortality rate than B and V groups (62% vs. 40% and 35%, p = 0.3) and a significantly longer length of stay (31 days (18–48)) than V group (5 days (3–11), p = 0.0002)) and B group (14.5 days (5.5–25.5), p = 0.007)). Among the 15 patients with available mPCR tests before viral HAP, seven were negative and eight were positive corresponding to long-term carriage of community-acquired viruses. DISCUSSION: RVs were detected in 32% of HAP patients who underwent mPCR. Two situations were encountered: (i) acute acquired viral infection; (ii) long-term viral carriage (mostly rhinovirus) especially in immunocompromised patients complicated by a virus/bacteria coinfection. The latter was associated with a longer length of stay and a trend toward a higher mortality.
format Online
Article
Text
id pubmed-7106511
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Elsevier B.V.
record_format MEDLINE/PubMed
spelling pubmed-71065112020-03-31 Impact of respiratory viruses in hospital-acquired pneumonia in the intensive care unit: A single-center retrospective study Loubet, Paul Voiriot, Guillaume Houhou-Fidouh, Nadhira Neuville, Mathilde Bouadma, Lila Lescure, Francois-Xavier Descamps, Diane Timsit, Jean-François Yazdanpanah, Yazdan Visseaux, Benoit J Clin Virol Article BACKGROUND: Data on the frequency and role of respiratory viruses (RVs) in hospital-acquired pneumonia (HAP) are still scarce. OBJECTIVES: We assessed the proportion of RVs and their impact on the outcome of hospital-acquired pneumonia (HAP) in the intensive care unit (ICU). STUDY DESIGN: Cases of HAP were retrospectively selected among patients who underwent screening for RVs by multiplex PCR (mPCR) in the ICU of a French tertiary care hospital from May 2014 to April 2016. ICU length of stay and in-hospital mortality were compared between four groups defined according to the identified pathogens: virus only (V), virus/bacteria (V/B), bacteria only (B) and no pathogen (Neg). When available, previous mPCR was retrieved in order to assess possible chronic viral carriage. RESULTS: Overall, 95/999 (10%) ICU patients who underwent mPCR had HAP (V(17,18%), V/B(13,14%), B(60,63%), Neg(5,5%)). Median age was 61 years and 45 (47%) were immunocompromised. Influenza (27%) and rhinovirus (27%) were the most common RVs. V/B group had higher mortality rate than B and V groups (62% vs. 40% and 35%, p = 0.3) and a significantly longer length of stay (31 days (18–48)) than V group (5 days (3–11), p = 0.0002)) and B group (14.5 days (5.5–25.5), p = 0.007)). Among the 15 patients with available mPCR tests before viral HAP, seven were negative and eight were positive corresponding to long-term carriage of community-acquired viruses. DISCUSSION: RVs were detected in 32% of HAP patients who underwent mPCR. Two situations were encountered: (i) acute acquired viral infection; (ii) long-term viral carriage (mostly rhinovirus) especially in immunocompromised patients complicated by a virus/bacteria coinfection. The latter was associated with a longer length of stay and a trend toward a higher mortality. Elsevier B.V. 2017-06 2017-04-22 /pmc/articles/PMC7106511/ /pubmed/28494435 http://dx.doi.org/10.1016/j.jcv.2017.04.001 Text en © 2017 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Loubet, Paul
Voiriot, Guillaume
Houhou-Fidouh, Nadhira
Neuville, Mathilde
Bouadma, Lila
Lescure, Francois-Xavier
Descamps, Diane
Timsit, Jean-François
Yazdanpanah, Yazdan
Visseaux, Benoit
Impact of respiratory viruses in hospital-acquired pneumonia in the intensive care unit: A single-center retrospective study
title Impact of respiratory viruses in hospital-acquired pneumonia in the intensive care unit: A single-center retrospective study
title_full Impact of respiratory viruses in hospital-acquired pneumonia in the intensive care unit: A single-center retrospective study
title_fullStr Impact of respiratory viruses in hospital-acquired pneumonia in the intensive care unit: A single-center retrospective study
title_full_unstemmed Impact of respiratory viruses in hospital-acquired pneumonia in the intensive care unit: A single-center retrospective study
title_short Impact of respiratory viruses in hospital-acquired pneumonia in the intensive care unit: A single-center retrospective study
title_sort impact of respiratory viruses in hospital-acquired pneumonia in the intensive care unit: a single-center retrospective study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7106511/
https://www.ncbi.nlm.nih.gov/pubmed/28494435
http://dx.doi.org/10.1016/j.jcv.2017.04.001
work_keys_str_mv AT loubetpaul impactofrespiratoryvirusesinhospitalacquiredpneumoniaintheintensivecareunitasinglecenterretrospectivestudy
AT voiriotguillaume impactofrespiratoryvirusesinhospitalacquiredpneumoniaintheintensivecareunitasinglecenterretrospectivestudy
AT houhoufidouhnadhira impactofrespiratoryvirusesinhospitalacquiredpneumoniaintheintensivecareunitasinglecenterretrospectivestudy
AT neuvillemathilde impactofrespiratoryvirusesinhospitalacquiredpneumoniaintheintensivecareunitasinglecenterretrospectivestudy
AT bouadmalila impactofrespiratoryvirusesinhospitalacquiredpneumoniaintheintensivecareunitasinglecenterretrospectivestudy
AT lescurefrancoisxavier impactofrespiratoryvirusesinhospitalacquiredpneumoniaintheintensivecareunitasinglecenterretrospectivestudy
AT descampsdiane impactofrespiratoryvirusesinhospitalacquiredpneumoniaintheintensivecareunitasinglecenterretrospectivestudy
AT timsitjeanfrancois impactofrespiratoryvirusesinhospitalacquiredpneumoniaintheintensivecareunitasinglecenterretrospectivestudy
AT yazdanpanahyazdan impactofrespiratoryvirusesinhospitalacquiredpneumoniaintheintensivecareunitasinglecenterretrospectivestudy
AT visseauxbenoit impactofrespiratoryvirusesinhospitalacquiredpneumoniaintheintensivecareunitasinglecenterretrospectivestudy