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Impact of respiratory viruses in hospital-acquired pneumonia in the intensive care unit: A single-center retrospective study
BACKGROUND: Data on the frequency and role of respiratory viruses (RVs) in hospital-acquired pneumonia (HAP) are still scarce. OBJECTIVES: We assessed the proportion of RVs and their impact on the outcome of hospital-acquired pneumonia (HAP) in the intensive care unit (ICU). STUDY DESIGN: Cases of H...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier B.V.
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7106511/ https://www.ncbi.nlm.nih.gov/pubmed/28494435 http://dx.doi.org/10.1016/j.jcv.2017.04.001 |
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author | Loubet, Paul Voiriot, Guillaume Houhou-Fidouh, Nadhira Neuville, Mathilde Bouadma, Lila Lescure, Francois-Xavier Descamps, Diane Timsit, Jean-François Yazdanpanah, Yazdan Visseaux, Benoit |
author_facet | Loubet, Paul Voiriot, Guillaume Houhou-Fidouh, Nadhira Neuville, Mathilde Bouadma, Lila Lescure, Francois-Xavier Descamps, Diane Timsit, Jean-François Yazdanpanah, Yazdan Visseaux, Benoit |
author_sort | Loubet, Paul |
collection | PubMed |
description | BACKGROUND: Data on the frequency and role of respiratory viruses (RVs) in hospital-acquired pneumonia (HAP) are still scarce. OBJECTIVES: We assessed the proportion of RVs and their impact on the outcome of hospital-acquired pneumonia (HAP) in the intensive care unit (ICU). STUDY DESIGN: Cases of HAP were retrospectively selected among patients who underwent screening for RVs by multiplex PCR (mPCR) in the ICU of a French tertiary care hospital from May 2014 to April 2016. ICU length of stay and in-hospital mortality were compared between four groups defined according to the identified pathogens: virus only (V), virus/bacteria (V/B), bacteria only (B) and no pathogen (Neg). When available, previous mPCR was retrieved in order to assess possible chronic viral carriage. RESULTS: Overall, 95/999 (10%) ICU patients who underwent mPCR had HAP (V(17,18%), V/B(13,14%), B(60,63%), Neg(5,5%)). Median age was 61 years and 45 (47%) were immunocompromised. Influenza (27%) and rhinovirus (27%) were the most common RVs. V/B group had higher mortality rate than B and V groups (62% vs. 40% and 35%, p = 0.3) and a significantly longer length of stay (31 days (18–48)) than V group (5 days (3–11), p = 0.0002)) and B group (14.5 days (5.5–25.5), p = 0.007)). Among the 15 patients with available mPCR tests before viral HAP, seven were negative and eight were positive corresponding to long-term carriage of community-acquired viruses. DISCUSSION: RVs were detected in 32% of HAP patients who underwent mPCR. Two situations were encountered: (i) acute acquired viral infection; (ii) long-term viral carriage (mostly rhinovirus) especially in immunocompromised patients complicated by a virus/bacteria coinfection. The latter was associated with a longer length of stay and a trend toward a higher mortality. |
format | Online Article Text |
id | pubmed-7106511 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Elsevier B.V. |
record_format | MEDLINE/PubMed |
spelling | pubmed-71065112020-03-31 Impact of respiratory viruses in hospital-acquired pneumonia in the intensive care unit: A single-center retrospective study Loubet, Paul Voiriot, Guillaume Houhou-Fidouh, Nadhira Neuville, Mathilde Bouadma, Lila Lescure, Francois-Xavier Descamps, Diane Timsit, Jean-François Yazdanpanah, Yazdan Visseaux, Benoit J Clin Virol Article BACKGROUND: Data on the frequency and role of respiratory viruses (RVs) in hospital-acquired pneumonia (HAP) are still scarce. OBJECTIVES: We assessed the proportion of RVs and their impact on the outcome of hospital-acquired pneumonia (HAP) in the intensive care unit (ICU). STUDY DESIGN: Cases of HAP were retrospectively selected among patients who underwent screening for RVs by multiplex PCR (mPCR) in the ICU of a French tertiary care hospital from May 2014 to April 2016. ICU length of stay and in-hospital mortality were compared between four groups defined according to the identified pathogens: virus only (V), virus/bacteria (V/B), bacteria only (B) and no pathogen (Neg). When available, previous mPCR was retrieved in order to assess possible chronic viral carriage. RESULTS: Overall, 95/999 (10%) ICU patients who underwent mPCR had HAP (V(17,18%), V/B(13,14%), B(60,63%), Neg(5,5%)). Median age was 61 years and 45 (47%) were immunocompromised. Influenza (27%) and rhinovirus (27%) were the most common RVs. V/B group had higher mortality rate than B and V groups (62% vs. 40% and 35%, p = 0.3) and a significantly longer length of stay (31 days (18–48)) than V group (5 days (3–11), p = 0.0002)) and B group (14.5 days (5.5–25.5), p = 0.007)). Among the 15 patients with available mPCR tests before viral HAP, seven were negative and eight were positive corresponding to long-term carriage of community-acquired viruses. DISCUSSION: RVs were detected in 32% of HAP patients who underwent mPCR. Two situations were encountered: (i) acute acquired viral infection; (ii) long-term viral carriage (mostly rhinovirus) especially in immunocompromised patients complicated by a virus/bacteria coinfection. The latter was associated with a longer length of stay and a trend toward a higher mortality. Elsevier B.V. 2017-06 2017-04-22 /pmc/articles/PMC7106511/ /pubmed/28494435 http://dx.doi.org/10.1016/j.jcv.2017.04.001 Text en © 2017 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Loubet, Paul Voiriot, Guillaume Houhou-Fidouh, Nadhira Neuville, Mathilde Bouadma, Lila Lescure, Francois-Xavier Descamps, Diane Timsit, Jean-François Yazdanpanah, Yazdan Visseaux, Benoit Impact of respiratory viruses in hospital-acquired pneumonia in the intensive care unit: A single-center retrospective study |
title | Impact of respiratory viruses in hospital-acquired pneumonia in the intensive care unit: A single-center retrospective study |
title_full | Impact of respiratory viruses in hospital-acquired pneumonia in the intensive care unit: A single-center retrospective study |
title_fullStr | Impact of respiratory viruses in hospital-acquired pneumonia in the intensive care unit: A single-center retrospective study |
title_full_unstemmed | Impact of respiratory viruses in hospital-acquired pneumonia in the intensive care unit: A single-center retrospective study |
title_short | Impact of respiratory viruses in hospital-acquired pneumonia in the intensive care unit: A single-center retrospective study |
title_sort | impact of respiratory viruses in hospital-acquired pneumonia in the intensive care unit: a single-center retrospective study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7106511/ https://www.ncbi.nlm.nih.gov/pubmed/28494435 http://dx.doi.org/10.1016/j.jcv.2017.04.001 |
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