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Respiratory viruses among children with non-severe community-acquired pneumonia: A prospective cohort study

BACKGROUND: Community-acquired pneumonia (CAP) causes a major burden to the health care system among children under-5 years worldwide. Information on respiratory viruses in non-severe CAP cases is scarce. OBJECTIVES: To estimate the frequency of respiratory viruses among non-severe CAP cases. STUDY...

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Autores principales: Nascimento-Carvalho, Amanda C., Vilas-Boas, Ana-Luisa, Fontoura, Maria-Socorro H., Vuorinen, Tytti, Nascimento-Carvalho, Cristiana M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7106541/
https://www.ncbi.nlm.nih.gov/pubmed/29908521
http://dx.doi.org/10.1016/j.jcv.2018.06.003
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author Nascimento-Carvalho, Amanda C.
Vilas-Boas, Ana-Luisa
Fontoura, Maria-Socorro H.
Vuorinen, Tytti
Nascimento-Carvalho, Cristiana M.
author_facet Nascimento-Carvalho, Amanda C.
Vilas-Boas, Ana-Luisa
Fontoura, Maria-Socorro H.
Vuorinen, Tytti
Nascimento-Carvalho, Cristiana M.
author_sort Nascimento-Carvalho, Amanda C.
collection PubMed
description BACKGROUND: Community-acquired pneumonia (CAP) causes a major burden to the health care system among children under-5 years worldwide. Information on respiratory viruses in non-severe CAP cases is scarce. OBJECTIVES: To estimate the frequency of respiratory viruses among non-severe CAP cases. STUDY DESIGN: Prospective study conducted in Salvador, Brazil. Out of 820 children aged 2–59 months with non-severe CAP diagnosed by pediatricians (respiratory complaints and radiographic pulmonary infiltrate/consolidation), recruited in a clinical trial (ClinicalTrials.gov Identifier NCT01200706), nasopharyngeal aspirate samples were obtained from 774 (94.4%) patients and tested for 16 respiratory viruses by PCRs. RESULTS: Viruses were detected in 708 (91.5%; 95%CI: 89.3–93.3) cases, out of which 491 (69.4%; 95%CI: 65.9–72.7) harbored multiple viruses. Rhinovirus (46.1%; 95%CI: 42.6–49.6), adenovirus (38.4%; 95%CI: 35.0–41.8), and enterovirus (26.5%; 95%CI: 23.5–29.7) were the most commonly found viruses. The most frequent combination comprised rhinovirus plus adenovirus. No difference was found in the frequency of RSVA (16.1% vs. 14.6%; P = 0.6), RSVB (10.9% vs. 13.2%; P = 0.4) influenza (Flu) A (6.3% vs. 5.1%; P = 0.5), FluB (4.5% vs. 1.8%; P = 0.09), parainfluenza virus (PIV) 1 (5.1% vs. 2.8%; P = 0.2), or PIV4 (7.7% vs. 4.1%; P = 0.08), when children with multiple or sole virus detection were compared. Conversely, rhinovirus, adenovirus, enterovirus, bocavirus, PIV2, PIV3, metapneumovirus, coronavirus OC43, NL63, 229E were significantly more frequent among cases with multiple virus detection. CONCLUSIONS: Respiratory viruses were detected in over 90% of the cases, out of which 70% had multiple viruses. Several viruses are more commonly found in multiple virus detection whereas other viruses are similarly found in sole and in multiple virus detection.
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spelling pubmed-71065412020-03-31 Respiratory viruses among children with non-severe community-acquired pneumonia: A prospective cohort study Nascimento-Carvalho, Amanda C. Vilas-Boas, Ana-Luisa Fontoura, Maria-Socorro H. Vuorinen, Tytti Nascimento-Carvalho, Cristiana M. J Clin Virol Article BACKGROUND: Community-acquired pneumonia (CAP) causes a major burden to the health care system among children under-5 years worldwide. Information on respiratory viruses in non-severe CAP cases is scarce. OBJECTIVES: To estimate the frequency of respiratory viruses among non-severe CAP cases. STUDY DESIGN: Prospective study conducted in Salvador, Brazil. Out of 820 children aged 2–59 months with non-severe CAP diagnosed by pediatricians (respiratory complaints and radiographic pulmonary infiltrate/consolidation), recruited in a clinical trial (ClinicalTrials.gov Identifier NCT01200706), nasopharyngeal aspirate samples were obtained from 774 (94.4%) patients and tested for 16 respiratory viruses by PCRs. RESULTS: Viruses were detected in 708 (91.5%; 95%CI: 89.3–93.3) cases, out of which 491 (69.4%; 95%CI: 65.9–72.7) harbored multiple viruses. Rhinovirus (46.1%; 95%CI: 42.6–49.6), adenovirus (38.4%; 95%CI: 35.0–41.8), and enterovirus (26.5%; 95%CI: 23.5–29.7) were the most commonly found viruses. The most frequent combination comprised rhinovirus plus adenovirus. No difference was found in the frequency of RSVA (16.1% vs. 14.6%; P = 0.6), RSVB (10.9% vs. 13.2%; P = 0.4) influenza (Flu) A (6.3% vs. 5.1%; P = 0.5), FluB (4.5% vs. 1.8%; P = 0.09), parainfluenza virus (PIV) 1 (5.1% vs. 2.8%; P = 0.2), or PIV4 (7.7% vs. 4.1%; P = 0.08), when children with multiple or sole virus detection were compared. Conversely, rhinovirus, adenovirus, enterovirus, bocavirus, PIV2, PIV3, metapneumovirus, coronavirus OC43, NL63, 229E were significantly more frequent among cases with multiple virus detection. CONCLUSIONS: Respiratory viruses were detected in over 90% of the cases, out of which 70% had multiple viruses. Several viruses are more commonly found in multiple virus detection whereas other viruses are similarly found in sole and in multiple virus detection. Elsevier B.V. 2018-08 2018-06-06 /pmc/articles/PMC7106541/ /pubmed/29908521 http://dx.doi.org/10.1016/j.jcv.2018.06.003 Text en © 2018 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Nascimento-Carvalho, Amanda C.
Vilas-Boas, Ana-Luisa
Fontoura, Maria-Socorro H.
Vuorinen, Tytti
Nascimento-Carvalho, Cristiana M.
Respiratory viruses among children with non-severe community-acquired pneumonia: A prospective cohort study
title Respiratory viruses among children with non-severe community-acquired pneumonia: A prospective cohort study
title_full Respiratory viruses among children with non-severe community-acquired pneumonia: A prospective cohort study
title_fullStr Respiratory viruses among children with non-severe community-acquired pneumonia: A prospective cohort study
title_full_unstemmed Respiratory viruses among children with non-severe community-acquired pneumonia: A prospective cohort study
title_short Respiratory viruses among children with non-severe community-acquired pneumonia: A prospective cohort study
title_sort respiratory viruses among children with non-severe community-acquired pneumonia: a prospective cohort study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7106541/
https://www.ncbi.nlm.nih.gov/pubmed/29908521
http://dx.doi.org/10.1016/j.jcv.2018.06.003
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