Cargando…

Methicillin-resistant Staphylococcus aureus nasal colonization among HIV-infected patients in Taiwan: prevalence, molecular characteristics and associated factors with nasal carriage

BACKGROUND: To evaluate nasal carriage, antibiotic susceptibility and molecular characteristics of methicillin-resistant Staphylococcus aureus (MRSA), as well as the risk factors of MRSA colonization, in human immunodeficiency virus (HIV)-infected patients in northern Taiwan. METHODS: From September...

Descripción completa

Detalles Bibliográficos
Autores principales: Hsu, Yi-Yu, Wu, David, Hung, Chien-Ching, Huang, Shie-Shian, Yuan, Fang-Hsueh, Lee, Ming-Hsun, Huang, Ching-Tai, Shie, Shian-Sen, Huang, Po-Yen, Yang, Chien-Chang, Cheng, Chun-Wen, Leu, Hsieh-Shong, Wu, Ting-Shu, Huang, Yhu-Chering
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7106609/
https://www.ncbi.nlm.nih.gov/pubmed/32228480
http://dx.doi.org/10.1186/s12879-020-04979-8
_version_ 1783512643049357312
author Hsu, Yi-Yu
Wu, David
Hung, Chien-Ching
Huang, Shie-Shian
Yuan, Fang-Hsueh
Lee, Ming-Hsun
Huang, Ching-Tai
Shie, Shian-Sen
Huang, Po-Yen
Yang, Chien-Chang
Cheng, Chun-Wen
Leu, Hsieh-Shong
Wu, Ting-Shu
Huang, Yhu-Chering
author_facet Hsu, Yi-Yu
Wu, David
Hung, Chien-Ching
Huang, Shie-Shian
Yuan, Fang-Hsueh
Lee, Ming-Hsun
Huang, Ching-Tai
Shie, Shian-Sen
Huang, Po-Yen
Yang, Chien-Chang
Cheng, Chun-Wen
Leu, Hsieh-Shong
Wu, Ting-Shu
Huang, Yhu-Chering
author_sort Hsu, Yi-Yu
collection PubMed
description BACKGROUND: To evaluate nasal carriage, antibiotic susceptibility and molecular characteristics of methicillin-resistant Staphylococcus aureus (MRSA), as well as the risk factors of MRSA colonization, in human immunodeficiency virus (HIV)-infected patients in northern Taiwan. METHODS: From September 2014 to November 2015, HIV-infected patients seeking outpatient care at four hospitals were eligible for this study. A nasal specimen was obtained from each subject for the detection of S. aureus and a questionnaire was completed by each subject. MRSA isolates once identified were characterized. RESULTS: Of 553 patients surveyed, methicillin-susceptible S. aureus (MSSA) was detected in 119 subjects (21.5%) and MRSA in 19 subjects (3.4%). Female gender, injection drug use, smoking, hepatitis C virus carrier, cancer and antibiotic use within 1 year were positively associated with MRSA colonization. By multivariate analysis, only cancer (adjust odds ratio (aOR) 7.78, [95% confidence interval (CI), 1.909–31.731]) and antibiotic use within 1 year (aOR 3.89, [95% CI, 1.219–12.433]) were significantly associated with MRSA colonization. Ten isolates were characterized as sequence type (ST) 59/staphylococcal chromosome cassette (SCC) IV or V(T), endemic community strains in Taiwan, four isolates as ST 8/SCCmec IV (USA 300) and one isolate as ST 239/SCCmec IIIA, a hospital strain. All the community-associated MRSA isolates were susceptible to trimethoprim-sulfamethoxazole (TMP-SMX). CONCLUSIONS: Nasal MRSA carriage in HIV-infected patients seeking outpatient care was low (3.4%) in northern Taiwan. Most of the colonizing isolates were genetically endemic community strains and exhibited high susceptibility to TMP-SMX and fluoroquinolones. Cancer and antibiotic use within 1 year were associated with MRSA colonization.
format Online
Article
Text
id pubmed-7106609
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-71066092020-04-01 Methicillin-resistant Staphylococcus aureus nasal colonization among HIV-infected patients in Taiwan: prevalence, molecular characteristics and associated factors with nasal carriage Hsu, Yi-Yu Wu, David Hung, Chien-Ching Huang, Shie-Shian Yuan, Fang-Hsueh Lee, Ming-Hsun Huang, Ching-Tai Shie, Shian-Sen Huang, Po-Yen Yang, Chien-Chang Cheng, Chun-Wen Leu, Hsieh-Shong Wu, Ting-Shu Huang, Yhu-Chering BMC Infect Dis Research Article BACKGROUND: To evaluate nasal carriage, antibiotic susceptibility and molecular characteristics of methicillin-resistant Staphylococcus aureus (MRSA), as well as the risk factors of MRSA colonization, in human immunodeficiency virus (HIV)-infected patients in northern Taiwan. METHODS: From September 2014 to November 2015, HIV-infected patients seeking outpatient care at four hospitals were eligible for this study. A nasal specimen was obtained from each subject for the detection of S. aureus and a questionnaire was completed by each subject. MRSA isolates once identified were characterized. RESULTS: Of 553 patients surveyed, methicillin-susceptible S. aureus (MSSA) was detected in 119 subjects (21.5%) and MRSA in 19 subjects (3.4%). Female gender, injection drug use, smoking, hepatitis C virus carrier, cancer and antibiotic use within 1 year were positively associated with MRSA colonization. By multivariate analysis, only cancer (adjust odds ratio (aOR) 7.78, [95% confidence interval (CI), 1.909–31.731]) and antibiotic use within 1 year (aOR 3.89, [95% CI, 1.219–12.433]) were significantly associated with MRSA colonization. Ten isolates were characterized as sequence type (ST) 59/staphylococcal chromosome cassette (SCC) IV or V(T), endemic community strains in Taiwan, four isolates as ST 8/SCCmec IV (USA 300) and one isolate as ST 239/SCCmec IIIA, a hospital strain. All the community-associated MRSA isolates were susceptible to trimethoprim-sulfamethoxazole (TMP-SMX). CONCLUSIONS: Nasal MRSA carriage in HIV-infected patients seeking outpatient care was low (3.4%) in northern Taiwan. Most of the colonizing isolates were genetically endemic community strains and exhibited high susceptibility to TMP-SMX and fluoroquinolones. Cancer and antibiotic use within 1 year were associated with MRSA colonization. BioMed Central 2020-03-30 /pmc/articles/PMC7106609/ /pubmed/32228480 http://dx.doi.org/10.1186/s12879-020-04979-8 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Article
Hsu, Yi-Yu
Wu, David
Hung, Chien-Ching
Huang, Shie-Shian
Yuan, Fang-Hsueh
Lee, Ming-Hsun
Huang, Ching-Tai
Shie, Shian-Sen
Huang, Po-Yen
Yang, Chien-Chang
Cheng, Chun-Wen
Leu, Hsieh-Shong
Wu, Ting-Shu
Huang, Yhu-Chering
Methicillin-resistant Staphylococcus aureus nasal colonization among HIV-infected patients in Taiwan: prevalence, molecular characteristics and associated factors with nasal carriage
title Methicillin-resistant Staphylococcus aureus nasal colonization among HIV-infected patients in Taiwan: prevalence, molecular characteristics and associated factors with nasal carriage
title_full Methicillin-resistant Staphylococcus aureus nasal colonization among HIV-infected patients in Taiwan: prevalence, molecular characteristics and associated factors with nasal carriage
title_fullStr Methicillin-resistant Staphylococcus aureus nasal colonization among HIV-infected patients in Taiwan: prevalence, molecular characteristics and associated factors with nasal carriage
title_full_unstemmed Methicillin-resistant Staphylococcus aureus nasal colonization among HIV-infected patients in Taiwan: prevalence, molecular characteristics and associated factors with nasal carriage
title_short Methicillin-resistant Staphylococcus aureus nasal colonization among HIV-infected patients in Taiwan: prevalence, molecular characteristics and associated factors with nasal carriage
title_sort methicillin-resistant staphylococcus aureus nasal colonization among hiv-infected patients in taiwan: prevalence, molecular characteristics and associated factors with nasal carriage
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7106609/
https://www.ncbi.nlm.nih.gov/pubmed/32228480
http://dx.doi.org/10.1186/s12879-020-04979-8
work_keys_str_mv AT hsuyiyu methicillinresistantstaphylococcusaureusnasalcolonizationamonghivinfectedpatientsintaiwanprevalencemolecularcharacteristicsandassociatedfactorswithnasalcarriage
AT wudavid methicillinresistantstaphylococcusaureusnasalcolonizationamonghivinfectedpatientsintaiwanprevalencemolecularcharacteristicsandassociatedfactorswithnasalcarriage
AT hungchienching methicillinresistantstaphylococcusaureusnasalcolonizationamonghivinfectedpatientsintaiwanprevalencemolecularcharacteristicsandassociatedfactorswithnasalcarriage
AT huangshieshian methicillinresistantstaphylococcusaureusnasalcolonizationamonghivinfectedpatientsintaiwanprevalencemolecularcharacteristicsandassociatedfactorswithnasalcarriage
AT yuanfanghsueh methicillinresistantstaphylococcusaureusnasalcolonizationamonghivinfectedpatientsintaiwanprevalencemolecularcharacteristicsandassociatedfactorswithnasalcarriage
AT leeminghsun methicillinresistantstaphylococcusaureusnasalcolonizationamonghivinfectedpatientsintaiwanprevalencemolecularcharacteristicsandassociatedfactorswithnasalcarriage
AT huangchingtai methicillinresistantstaphylococcusaureusnasalcolonizationamonghivinfectedpatientsintaiwanprevalencemolecularcharacteristicsandassociatedfactorswithnasalcarriage
AT shieshiansen methicillinresistantstaphylococcusaureusnasalcolonizationamonghivinfectedpatientsintaiwanprevalencemolecularcharacteristicsandassociatedfactorswithnasalcarriage
AT huangpoyen methicillinresistantstaphylococcusaureusnasalcolonizationamonghivinfectedpatientsintaiwanprevalencemolecularcharacteristicsandassociatedfactorswithnasalcarriage
AT yangchienchang methicillinresistantstaphylococcusaureusnasalcolonizationamonghivinfectedpatientsintaiwanprevalencemolecularcharacteristicsandassociatedfactorswithnasalcarriage
AT chengchunwen methicillinresistantstaphylococcusaureusnasalcolonizationamonghivinfectedpatientsintaiwanprevalencemolecularcharacteristicsandassociatedfactorswithnasalcarriage
AT leuhsiehshong methicillinresistantstaphylococcusaureusnasalcolonizationamonghivinfectedpatientsintaiwanprevalencemolecularcharacteristicsandassociatedfactorswithnasalcarriage
AT wutingshu methicillinresistantstaphylococcusaureusnasalcolonizationamonghivinfectedpatientsintaiwanprevalencemolecularcharacteristicsandassociatedfactorswithnasalcarriage
AT huangyhuchering methicillinresistantstaphylococcusaureusnasalcolonizationamonghivinfectedpatientsintaiwanprevalencemolecularcharacteristicsandassociatedfactorswithnasalcarriage