Optimization of parasite DNA enrichment approaches to generate whole genome sequencing data for Plasmodium falciparum from low parasitaemia samples

BACKGROUND: Owing to the large amount of host DNA in clinical samples, generation of high-quality Plasmodium falciparum whole genome sequencing (WGS) data requires enrichment for parasite DNA. Enrichment is often achieved by leukocyte depletion of infected blood prior to storage. However, leukocyte...

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Detalles Bibliográficos
Autores principales: Shah, Zalak, Adams, Matthew, Moser, Kara A., Shrestha, Biraj, Stucke, Emily M., Laufer, Miriam K., Serre, David, Silva, Joana C., Takala-Harrison, Shannon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Methodology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7106660/
https://www.ncbi.nlm.nih.gov/pubmed/32228559
http://dx.doi.org/10.1186/s12936-020-03195-8

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