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Laminin 221 fragment is suitable for the differentiation of human induced pluripotent stem cells into brain microvascular endothelial-like cells with robust barrier integrity

BACKGROUND: In vitro blood–brain barrier (BBB) models using human induced pluripotent stem (iPS) cell-derived brain microvascular endothelial-like cells (iBMELCs) have been developed to predict the BBB permeability of drug candidates. For the differentiation of iBMELCs, Matrigel, which is a gelatino...

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Detalles Bibliográficos
Autores principales:	Aoki, Hiromasa, Yamashita, Misaki, Hashita, Tadahiro, Iwao, Takahiro, Matsunaga, Tamihide
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7106710/ https://www.ncbi.nlm.nih.gov/pubmed/32228708 http://dx.doi.org/10.1186/s12987-020-00186-4

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