Reversible inhibitor of CRM1 sensitizes glioblastoma cells to radiation by blocking the NF-κB signaling pathway

BACKGROUND: Activation of nuclear factor-kappa B (NF-κΒ) through DNA damage is one of the causes of tumor cell resistance to radiotherapy. Chromosome region 1 (CRM1) regulates tumor cell proliferation, drug resistance, and radiation resistance by regulating the nuclear-cytoplasmic translocation of i...

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Detalles Bibliográficos
Autores principales: Liu, Xuejiao, Tu, Yiming, Wang, Yifeng, Zhou, Di, Chong, Yulong, Shi, Lin, Liu, Guanzheng, Zhang, Xu, Wu, Sijin, Li, Huan, Gao, Shangfeng, Niu, Mingshan, Yu, Rutong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Primary Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7106748/
https://www.ncbi.nlm.nih.gov/pubmed/32256206
http://dx.doi.org/10.1186/s12935-020-01186-y

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