Cargando…

Application of Needleman-Wunch Algorithm to identify mutation in DNA sequences of Corona virus

—Corona virus is a virus capable of mutating very quickly and many other viruses that arise due to mutations of this virus. To find out the location of corona virus mutations of one type to another, DNA sequences can be aligned using the Needleman-Wunsch algorithm. Corona virus data was taken from G...

Descripción completa

Detalles Bibliográficos
Autores principales: Isa Irawan, Mohammad, Mukhlash, Imam, Rizky, Abduh, Ririsati Dewi, Alfiana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOP Publishing 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7106772/
https://www.ncbi.nlm.nih.gov/pubmed/32288776
http://dx.doi.org/10.1088/1742-6596/1218/1/012031
_version_ 1783512683693211648
author Isa Irawan, Mohammad
Mukhlash, Imam
Rizky, Abduh
Ririsati Dewi, Alfiana
author_facet Isa Irawan, Mohammad
Mukhlash, Imam
Rizky, Abduh
Ririsati Dewi, Alfiana
author_sort Isa Irawan, Mohammad
collection PubMed
description —Corona virus is a virus capable of mutating very quickly and many other viruses that arise due to mutations of this virus. To find out the location of corona virus mutations of one type to another, DNA sequences can be aligned using the Needleman-Wunsch algorithm. Corona virus data was taken from Genbank National Center for Biotechnology Information from 1985-1992. The Needleman-Wunsch algorithm is a global alignment algorithm in which alignment is performed to all sequences with the complexity of O (mn) and is capable of producing optimal alignment. An important step in this reserach is the sequence alignment of two corona viruses using the Needleman-Wunsch algorithm. Second, identification of the location of mutations from the DNA of the virus. The result of this reserach is an alignment and the location of mutations of both sequences. The results of identification DNA mutation can be used to find out other viruses mutation corona virus as well as can be used in the field of health as a reference for the manufacture of drugs for corona virus mutation outcome.
format Online
Article
Text
id pubmed-7106772
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher IOP Publishing
record_format MEDLINE/PubMed
spelling pubmed-71067722020-04-03 Application of Needleman-Wunch Algorithm to identify mutation in DNA sequences of Corona virus Isa Irawan, Mohammad Mukhlash, Imam Rizky, Abduh Ririsati Dewi, Alfiana J Phys Conf Ser Paper —Corona virus is a virus capable of mutating very quickly and many other viruses that arise due to mutations of this virus. To find out the location of corona virus mutations of one type to another, DNA sequences can be aligned using the Needleman-Wunsch algorithm. Corona virus data was taken from Genbank National Center for Biotechnology Information from 1985-1992. The Needleman-Wunsch algorithm is a global alignment algorithm in which alignment is performed to all sequences with the complexity of O (mn) and is capable of producing optimal alignment. An important step in this reserach is the sequence alignment of two corona viruses using the Needleman-Wunsch algorithm. Second, identification of the location of mutations from the DNA of the virus. The result of this reserach is an alignment and the location of mutations of both sequences. The results of identification DNA mutation can be used to find out other viruses mutation corona virus as well as can be used in the field of health as a reference for the manufacture of drugs for corona virus mutation outcome. IOP Publishing 2019-05 2019-05-01 /pmc/articles/PMC7106772/ /pubmed/32288776 http://dx.doi.org/10.1088/1742-6596/1218/1/012031 Text en Published under licence by IOP Publishing Ltd This article is made available via the PMC Open Access Subset for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. http://creativecommons.org/licenses/by/3.0/ Content from this work may be used under the terms of the Creative Commons Attribution 3.0 licence (http://creativecommons.org/licenses/by/3.0) . Any further distribution of this work must maintain attribution to the author(s) and the title of the work, journal citation and DOI.
spellingShingle Paper
Isa Irawan, Mohammad
Mukhlash, Imam
Rizky, Abduh
Ririsati Dewi, Alfiana
Application of Needleman-Wunch Algorithm to identify mutation in DNA sequences of Corona virus
title Application of Needleman-Wunch Algorithm to identify mutation in DNA sequences of Corona virus
title_full Application of Needleman-Wunch Algorithm to identify mutation in DNA sequences of Corona virus
title_fullStr Application of Needleman-Wunch Algorithm to identify mutation in DNA sequences of Corona virus
title_full_unstemmed Application of Needleman-Wunch Algorithm to identify mutation in DNA sequences of Corona virus
title_short Application of Needleman-Wunch Algorithm to identify mutation in DNA sequences of Corona virus
title_sort application of needleman-wunch algorithm to identify mutation in dna sequences of corona virus
topic Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7106772/
https://www.ncbi.nlm.nih.gov/pubmed/32288776
http://dx.doi.org/10.1088/1742-6596/1218/1/012031
work_keys_str_mv AT isairawanmohammad applicationofneedlemanwunchalgorithmtoidentifymutationindnasequencesofcoronavirus
AT mukhlashimam applicationofneedlemanwunchalgorithmtoidentifymutationindnasequencesofcoronavirus
AT rizkyabduh applicationofneedlemanwunchalgorithmtoidentifymutationindnasequencesofcoronavirus
AT ririsatidewialfiana applicationofneedlemanwunchalgorithmtoidentifymutationindnasequencesofcoronavirus