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Inactivation of airborne viruses using a packed bed non-thermal plasma reactor

Outbreaks of airborne infectious diseases such as measles or severe acute respiratory syndrome can cause significant public alarm. Where ventilation systems facilitate disease transmission to humans or animals, there exists a need for control measures that provide effective protection while imposing...

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Detalles Bibliográficos
Autores principales: Xia, T, Kleinheksel, A, Lee, E M, Qiao, Z, Wigginton, K R, Clack, H L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOP Publishing 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7106774/
https://www.ncbi.nlm.nih.gov/pubmed/32287389
http://dx.doi.org/10.1088/1361-6463/ab1466
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author Xia, T
Kleinheksel, A
Lee, E M
Qiao, Z
Wigginton, K R
Clack, H L
author_facet Xia, T
Kleinheksel, A
Lee, E M
Qiao, Z
Wigginton, K R
Clack, H L
author_sort Xia, T
collection PubMed
description Outbreaks of airborne infectious diseases such as measles or severe acute respiratory syndrome can cause significant public alarm. Where ventilation systems facilitate disease transmission to humans or animals, there exists a need for control measures that provide effective protection while imposing minimal pressure differential. In the present study, viral aerosols in an airstream were subjected to non-thermal plasma (NTP) exposure within a packed-bed dielectric barrier discharge reactor. Comparisons of plaque assays before and after NTP treatment found exponentially increasing inactivation of aerosolized MS2 phage with increasing applied voltage. At 30 kV and an air flow rate of 170 standard liters per minute, a greater than 2.3 log reduction of infective virus was achieved across the reactor. This reduction represented ~2 log of the MS2 inactivated and ~0.35 log physically removed in the packed bed. Increasing the air flow rate from 170 to 330 liters per minute did not significantly impact virus inactivation effectiveness. Activated carbon-based ozone filters greatly reduced residual ozone, in some cases down to background levels, while adding less than 20 Pa pressure differential to the 45 Pa differential pressure across the packed bed at the flow rate of 170 standard liters per minute.
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spelling pubmed-71067742020-04-03 Inactivation of airborne viruses using a packed bed non-thermal plasma reactor Xia, T Kleinheksel, A Lee, E M Qiao, Z Wigginton, K R Clack, H L J Phys D Appl Phys Paper Outbreaks of airborne infectious diseases such as measles or severe acute respiratory syndrome can cause significant public alarm. Where ventilation systems facilitate disease transmission to humans or animals, there exists a need for control measures that provide effective protection while imposing minimal pressure differential. In the present study, viral aerosols in an airstream were subjected to non-thermal plasma (NTP) exposure within a packed-bed dielectric barrier discharge reactor. Comparisons of plaque assays before and after NTP treatment found exponentially increasing inactivation of aerosolized MS2 phage with increasing applied voltage. At 30 kV and an air flow rate of 170 standard liters per minute, a greater than 2.3 log reduction of infective virus was achieved across the reactor. This reduction represented ~2 log of the MS2 inactivated and ~0.35 log physically removed in the packed bed. Increasing the air flow rate from 170 to 330 liters per minute did not significantly impact virus inactivation effectiveness. Activated carbon-based ozone filters greatly reduced residual ozone, in some cases down to background levels, while adding less than 20 Pa pressure differential to the 45 Pa differential pressure across the packed bed at the flow rate of 170 standard liters per minute. IOP Publishing 2019-06-19 2019-04-23 /pmc/articles/PMC7106774/ /pubmed/32287389 http://dx.doi.org/10.1088/1361-6463/ab1466 Text en © 2019 IOP Publishing Ltd This article is made available via the PMC Open Access Subset for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source.
spellingShingle Paper
Xia, T
Kleinheksel, A
Lee, E M
Qiao, Z
Wigginton, K R
Clack, H L
Inactivation of airborne viruses using a packed bed non-thermal plasma reactor
title Inactivation of airborne viruses using a packed bed non-thermal plasma reactor
title_full Inactivation of airborne viruses using a packed bed non-thermal plasma reactor
title_fullStr Inactivation of airborne viruses using a packed bed non-thermal plasma reactor
title_full_unstemmed Inactivation of airborne viruses using a packed bed non-thermal plasma reactor
title_short Inactivation of airborne viruses using a packed bed non-thermal plasma reactor
title_sort inactivation of airborne viruses using a packed bed non-thermal plasma reactor
topic Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7106774/
https://www.ncbi.nlm.nih.gov/pubmed/32287389
http://dx.doi.org/10.1088/1361-6463/ab1466
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