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Multi-scale problem in the model of RNA virus evolution

A mathematical or computational model in evolutionary biology should necessary combine several comparatively fast processes, which actually drive natural selection and evolution, with a very slow process of evolution. As a result, several very different time scales are simultaneously present in the...

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Detalles Bibliográficos
Autores principales: Korobeinikov, Andrei, Archibasov, Aleksei, Sobolev, Vladimir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOP Publishing 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7106948/
https://www.ncbi.nlm.nih.gov/pubmed/32288778
http://dx.doi.org/10.1088/1742-6596/727/1/012007
Descripción
Sumario:A mathematical or computational model in evolutionary biology should necessary combine several comparatively fast processes, which actually drive natural selection and evolution, with a very slow process of evolution. As a result, several very different time scales are simultaneously present in the model; this makes its analytical study an extremely difficult task. However, the significant difference of the time scales implies the existence of a possibility of the model order reduction through a process of time separation. In this paper we conduct the procedure of model order reduction for a reasonably simple model of RNA virus evolution reducing the original system of three integro-partial derivative equations to a single equation. Computations confirm that there is a good fit between the results for the original and reduced models.