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Multi-scale problem in the model of RNA virus evolution
A mathematical or computational model in evolutionary biology should necessary combine several comparatively fast processes, which actually drive natural selection and evolution, with a very slow process of evolution. As a result, several very different time scales are simultaneously present in the...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
IOP Publishing
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7106948/ https://www.ncbi.nlm.nih.gov/pubmed/32288778 http://dx.doi.org/10.1088/1742-6596/727/1/012007 |
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author | Korobeinikov, Andrei Archibasov, Aleksei Sobolev, Vladimir |
author_facet | Korobeinikov, Andrei Archibasov, Aleksei Sobolev, Vladimir |
author_sort | Korobeinikov, Andrei |
collection | PubMed |
description | A mathematical or computational model in evolutionary biology should necessary combine several comparatively fast processes, which actually drive natural selection and evolution, with a very slow process of evolution. As a result, several very different time scales are simultaneously present in the model; this makes its analytical study an extremely difficult task. However, the significant difference of the time scales implies the existence of a possibility of the model order reduction through a process of time separation. In this paper we conduct the procedure of model order reduction for a reasonably simple model of RNA virus evolution reducing the original system of three integro-partial derivative equations to a single equation. Computations confirm that there is a good fit between the results for the original and reduced models. |
format | Online Article Text |
id | pubmed-7106948 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | IOP Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-71069482020-04-03 Multi-scale problem in the model of RNA virus evolution Korobeinikov, Andrei Archibasov, Aleksei Sobolev, Vladimir J Phys Conf Ser Paper A mathematical or computational model in evolutionary biology should necessary combine several comparatively fast processes, which actually drive natural selection and evolution, with a very slow process of evolution. As a result, several very different time scales are simultaneously present in the model; this makes its analytical study an extremely difficult task. However, the significant difference of the time scales implies the existence of a possibility of the model order reduction through a process of time separation. In this paper we conduct the procedure of model order reduction for a reasonably simple model of RNA virus evolution reducing the original system of three integro-partial derivative equations to a single equation. Computations confirm that there is a good fit between the results for the original and reduced models. IOP Publishing 2016-06 /pmc/articles/PMC7106948/ /pubmed/32288778 http://dx.doi.org/10.1088/1742-6596/727/1/012007 Text en Published under licence by IOP Publishing Ltd https://creativecommons.org/licenses/by/3.0/Content from this work may be used under the terms of the Creative Commons Attribution 3.0 licence (https://creativecommons.org/licenses/by/3.0/) . Any further distribution of this work must maintain attribution to the author(s) and the title of the work, journal citation and DOI. |
spellingShingle | Paper Korobeinikov, Andrei Archibasov, Aleksei Sobolev, Vladimir Multi-scale problem in the model of RNA virus evolution |
title | Multi-scale problem in the model of RNA virus evolution |
title_full | Multi-scale problem in the model of RNA virus evolution |
title_fullStr | Multi-scale problem in the model of RNA virus evolution |
title_full_unstemmed | Multi-scale problem in the model of RNA virus evolution |
title_short | Multi-scale problem in the model of RNA virus evolution |
title_sort | multi-scale problem in the model of rna virus evolution |
topic | Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7106948/ https://www.ncbi.nlm.nih.gov/pubmed/32288778 http://dx.doi.org/10.1088/1742-6596/727/1/012007 |
work_keys_str_mv | AT korobeinikovandrei multiscaleprobleminthemodelofrnavirusevolution AT archibasovaleksei multiscaleprobleminthemodelofrnavirusevolution AT sobolevvladimir multiscaleprobleminthemodelofrnavirusevolution |