The role of the cancer testis antigen PRAME in tumorigenesis and immunotherapy in human cancer

Preferentially expressed antigen in melanoma (PRAME), which belongs to the cancer/testis antigen (CTA) gene family, plays a pivotal role in multiple cellular processes and immunotherapy response in human cancers. PRAME is highly expressed in different types of cancers and is involved in cell prolife...

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Detalles Bibliográficos
Autores principales: Xu, Yichi, Zou, Ruanmin, Wang, Jing, Wang, Zhi‐wei, Zhu, Xueqiong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7106952/
https://www.ncbi.nlm.nih.gov/pubmed/32022332
http://dx.doi.org/10.1111/cpr.12770
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author Xu, Yichi
Zou, Ruanmin
Wang, Jing
Wang, Zhi‐wei
Zhu, Xueqiong
author_facet Xu, Yichi
Zou, Ruanmin
Wang, Jing
Wang, Zhi‐wei
Zhu, Xueqiong
author_sort Xu, Yichi
collection PubMed
description Preferentially expressed antigen in melanoma (PRAME), which belongs to the cancer/testis antigen (CTA) gene family, plays a pivotal role in multiple cellular processes and immunotherapy response in human cancers. PRAME is highly expressed in different types of cancers and is involved in cell proliferation, apoptosis, differentiation and metastasis as well as the outcomes of patients with cancer. In this review article, we discuss the potential roles and physiological functions of PRAME in various types of cancers. Moreover, this review highlights immunotherapeutic strategies that target PRAME in human malignancies. Therefore, the modulation of PRAME might be useful for the treatment of patients with cancer.
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spelling pubmed-71069522020-04-01 The role of the cancer testis antigen PRAME in tumorigenesis and immunotherapy in human cancer Xu, Yichi Zou, Ruanmin Wang, Jing Wang, Zhi‐wei Zhu, Xueqiong Cell Prolif Reviews Preferentially expressed antigen in melanoma (PRAME), which belongs to the cancer/testis antigen (CTA) gene family, plays a pivotal role in multiple cellular processes and immunotherapy response in human cancers. PRAME is highly expressed in different types of cancers and is involved in cell proliferation, apoptosis, differentiation and metastasis as well as the outcomes of patients with cancer. In this review article, we discuss the potential roles and physiological functions of PRAME in various types of cancers. Moreover, this review highlights immunotherapeutic strategies that target PRAME in human malignancies. Therefore, the modulation of PRAME might be useful for the treatment of patients with cancer. John Wiley and Sons Inc. 2020-02-05 /pmc/articles/PMC7106952/ /pubmed/32022332 http://dx.doi.org/10.1111/cpr.12770 Text en © 2020 The Authors. Cell Proliferation Published by John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Reviews
Xu, Yichi
Zou, Ruanmin
Wang, Jing
Wang, Zhi‐wei
Zhu, Xueqiong
The role of the cancer testis antigen PRAME in tumorigenesis and immunotherapy in human cancer
title The role of the cancer testis antigen PRAME in tumorigenesis and immunotherapy in human cancer
title_full The role of the cancer testis antigen PRAME in tumorigenesis and immunotherapy in human cancer
title_fullStr The role of the cancer testis antigen PRAME in tumorigenesis and immunotherapy in human cancer
title_full_unstemmed The role of the cancer testis antigen PRAME in tumorigenesis and immunotherapy in human cancer
title_short The role of the cancer testis antigen PRAME in tumorigenesis and immunotherapy in human cancer
title_sort role of the cancer testis antigen prame in tumorigenesis and immunotherapy in human cancer
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7106952/
https://www.ncbi.nlm.nih.gov/pubmed/32022332
http://dx.doi.org/10.1111/cpr.12770
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