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O-GlcNAcase targets pyruvate kinase M2 to regulate tumor growth

Cancer cells are known to adopt aerobic glycolysis in order to fuel tumor growth, but the molecular basis of this metabolic shift remains largely undefined. O-GlcNAcase (OGA) is an enzyme harboring O-linked β-N-acetylglucosamine (O-GlcNAc) hydrolase and cryptic lysine acetyltransferase activities. H...

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Detalles Bibliográficos
Autores principales:	Singh, Jay Prakash, Qian, Kevin, Lee, Jeong-Sang, Zhou, Jinfeng, Han, Xuemei, Zhang, Bichen, Ong, Qunxiang, Ni, Weiming, Jiang, Mingzuo, Ruan, Hai-Bin, Li, Min-Dian, Zhang, Kaisi, Ding, Zhaobing, Lee, Philip, Singh, Kamini, Wu, Jing, Herzog, Raimund I., Kaech, Susan, Wendel, Hans-Guido, Yates, John R., Han, Weiping, Sherwin, Robert S., Nie, Yongzhan, Yang, Xiaoyong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7107572/ https://www.ncbi.nlm.nih.gov/pubmed/31501520 http://dx.doi.org/10.1038/s41388-019-0975-3

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