A Phase 2b, Randomized, Double-blind, Placebo-Controlled Multicenter Study Evaluating Antiviral Effects, Pharmacokinetics, Safety, and Tolerability of Presatovir in Hematopoietic Cell Transplant Recipients with Respiratory Syncytial Virus Infection of the Lower Respiratory Tract

BACKGROUND: Presatovir significantly reduced nasal viral load, signs, and symptoms of respiratory syncytial virus (RSV) infection in a human challenge study. We evaluated presatovir in hematopoietic-cell transplant (HCT) recipients with RSV lower respiratory tract infection (LRTI). METHODS: Patients...

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Detalles Bibliográficos
Autores principales: Marty, Francisco M, Chemaly, Roy F, Mullane, Kathleen M, Lee, Dong-Gun, Hirsch, Hans H, Small, Catherine B, Bergeron, Anne, Shoham, Shmuel, Ljungman, Per, Waghmare, Alpana, Blanchard, Elodie, Kim, Yae-Jean, McKevitt, Matt, Porter, Danielle P, Jordan, Robert, Guo, Ying, German, Polina, Boeckh, Michael, Watkins, Timothy R, Chien, Jason W, Dadwal, Sanjeet S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Major Articles and Commentaries
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7108198/
https://www.ncbi.nlm.nih.gov/pubmed/31915807
http://dx.doi.org/10.1093/cid/ciz1167

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