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Crimean-Congo hemorrhagic fever in children

BACKGROUND: Crimean-Congo hemorrhagic fever (CCHF) virus causes a severe disease in humans with a mortality up to 30%. In Turkey there has been an increase in the number of cases during years since 2002. Humans of all ages living in endemic areas,especially those who are working as shepherds and tod...

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Autores principales: Tezer, Hasan, Sucaklı, Iclal Ayrancı, Saylı, Tulin Revide, Celikel, Elif, Yakut, Ibrahim, Kara, Ateş, Tunc, Bahattin, Ergonul, Onder
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7108219/
https://www.ncbi.nlm.nih.gov/pubmed/20444644
http://dx.doi.org/10.1016/j.jcv.2010.04.001
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author Tezer, Hasan
Sucaklı, Iclal Ayrancı
Saylı, Tulin Revide
Celikel, Elif
Yakut, Ibrahim
Kara, Ateş
Tunc, Bahattin
Ergonul, Onder
author_facet Tezer, Hasan
Sucaklı, Iclal Ayrancı
Saylı, Tulin Revide
Celikel, Elif
Yakut, Ibrahim
Kara, Ateş
Tunc, Bahattin
Ergonul, Onder
author_sort Tezer, Hasan
collection PubMed
description BACKGROUND: Crimean-Congo hemorrhagic fever (CCHF) virus causes a severe disease in humans with a mortality up to 30%. In Turkey there has been an increase in the number of cases during years since 2002. Humans of all ages living in endemic areas,especially those who are working as shepherds and toddlers, have high risk of acquiring CCHF. OBJECTIVES: The epidemiological, clinical, and laboratory characteristics of the children, who were diagnosed as Crimean-Congo hemorrhagic fever (CCHF) were described. STUDY DESIGN: The children infected with CCHF virus between April 2008 and October 2009, and hospitalised in Ankara Dışkapı Children's and Research Hospital were included. RESULTS: Laboratory diagnosis was set by detection of CCHF IgM antibodies and/or genetic detection of CCHF virus. Thirtyone cases included to the study, and all were from the northeastern Anatolia and the southern parts of Black sea region. The mean age was 9.45 ± 4.9 years, the proportion of females was 38.7%. The majority (87%) of the cases had the history of tick bite. There was no fatal case. All the patients had the history of fever. Malaise,tonsillopharyngitis, nausea-vomiting, headache, diarrhea, myalgia and rash were the most common symptoms. The mean AST and ALT levels on the admission were 116 (range 25–389) and 61 (range 8–180) U/L respectively. The mean platelet count on admission was 125,000/mm(3), and the lowest was 23,000/mm(3). The mean of the lowest white blood cell count was 2353/mm(3) and the mean of the highest lactate dehydrogenase was 861 IU/L. CONCLUSIONS: The clinical course of CCHF among children seems to be milder than in adults. Tonsillopharyngitis is a common symptom among children with CCHF.
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spelling pubmed-71082192020-03-31 Crimean-Congo hemorrhagic fever in children Tezer, Hasan Sucaklı, Iclal Ayrancı Saylı, Tulin Revide Celikel, Elif Yakut, Ibrahim Kara, Ateş Tunc, Bahattin Ergonul, Onder J Clin Virol Article BACKGROUND: Crimean-Congo hemorrhagic fever (CCHF) virus causes a severe disease in humans with a mortality up to 30%. In Turkey there has been an increase in the number of cases during years since 2002. Humans of all ages living in endemic areas,especially those who are working as shepherds and toddlers, have high risk of acquiring CCHF. OBJECTIVES: The epidemiological, clinical, and laboratory characteristics of the children, who were diagnosed as Crimean-Congo hemorrhagic fever (CCHF) were described. STUDY DESIGN: The children infected with CCHF virus between April 2008 and October 2009, and hospitalised in Ankara Dışkapı Children's and Research Hospital were included. RESULTS: Laboratory diagnosis was set by detection of CCHF IgM antibodies and/or genetic detection of CCHF virus. Thirtyone cases included to the study, and all were from the northeastern Anatolia and the southern parts of Black sea region. The mean age was 9.45 ± 4.9 years, the proportion of females was 38.7%. The majority (87%) of the cases had the history of tick bite. There was no fatal case. All the patients had the history of fever. Malaise,tonsillopharyngitis, nausea-vomiting, headache, diarrhea, myalgia and rash were the most common symptoms. The mean AST and ALT levels on the admission were 116 (range 25–389) and 61 (range 8–180) U/L respectively. The mean platelet count on admission was 125,000/mm(3), and the lowest was 23,000/mm(3). The mean of the lowest white blood cell count was 2353/mm(3) and the mean of the highest lactate dehydrogenase was 861 IU/L. CONCLUSIONS: The clinical course of CCHF among children seems to be milder than in adults. Tonsillopharyngitis is a common symptom among children with CCHF. Elsevier B.V. 2010-07 2010-05-04 /pmc/articles/PMC7108219/ /pubmed/20444644 http://dx.doi.org/10.1016/j.jcv.2010.04.001 Text en Copyright © 2010 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Tezer, Hasan
Sucaklı, Iclal Ayrancı
Saylı, Tulin Revide
Celikel, Elif
Yakut, Ibrahim
Kara, Ateş
Tunc, Bahattin
Ergonul, Onder
Crimean-Congo hemorrhagic fever in children
title Crimean-Congo hemorrhagic fever in children
title_full Crimean-Congo hemorrhagic fever in children
title_fullStr Crimean-Congo hemorrhagic fever in children
title_full_unstemmed Crimean-Congo hemorrhagic fever in children
title_short Crimean-Congo hemorrhagic fever in children
title_sort crimean-congo hemorrhagic fever in children
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7108219/
https://www.ncbi.nlm.nih.gov/pubmed/20444644
http://dx.doi.org/10.1016/j.jcv.2010.04.001
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