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Viral–bacterial co-infections in the respiratory tract

Preceding or concurrent viral respiratory tract infection can predispose to secondary bacterial co-infection throughout the airway. The mechanisms by which viruses promote these superinfections are diverse and replete. Whereas we understand much as to how viruses damage the airway and dysregulate bo...

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Detalles Bibliográficos
Autor principal: Bakaletz, Lauren O
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7108227/
https://www.ncbi.nlm.nih.gov/pubmed/27940028
http://dx.doi.org/10.1016/j.mib.2016.11.003
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author Bakaletz, Lauren O
author_facet Bakaletz, Lauren O
author_sort Bakaletz, Lauren O
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description Preceding or concurrent viral respiratory tract infection can predispose to secondary bacterial co-infection throughout the airway. The mechanisms by which viruses promote these superinfections are diverse and replete. Whereas we understand much as to how viruses damage the airway and dysregulate both innate and acquired immune responses which, in turn, supports bacterial growth, adherence and invasion into normally sterile sites within the respiratory tract, new information regarding these co-infections is being gained from recent advances in microbiome research and our enhanced appreciation of the contribution of bacterial biofilms, among others. The advanced understanding obtained by continued research efforts in all aspects of viral–bacterial co-infections of the respiratory tract will allow us to devise novel approaches for disease prevention as well as to develop more effective therapeutics.
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spelling pubmed-71082272020-03-31 Viral–bacterial co-infections in the respiratory tract Bakaletz, Lauren O Curr Opin Microbiol Article Preceding or concurrent viral respiratory tract infection can predispose to secondary bacterial co-infection throughout the airway. The mechanisms by which viruses promote these superinfections are diverse and replete. Whereas we understand much as to how viruses damage the airway and dysregulate both innate and acquired immune responses which, in turn, supports bacterial growth, adherence and invasion into normally sterile sites within the respiratory tract, new information regarding these co-infections is being gained from recent advances in microbiome research and our enhanced appreciation of the contribution of bacterial biofilms, among others. The advanced understanding obtained by continued research efforts in all aspects of viral–bacterial co-infections of the respiratory tract will allow us to devise novel approaches for disease prevention as well as to develop more effective therapeutics. Elsevier Ltd. 2017-02 2016-12-07 /pmc/articles/PMC7108227/ /pubmed/27940028 http://dx.doi.org/10.1016/j.mib.2016.11.003 Text en © 2016 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Bakaletz, Lauren O
Viral–bacterial co-infections in the respiratory tract
title Viral–bacterial co-infections in the respiratory tract
title_full Viral–bacterial co-infections in the respiratory tract
title_fullStr Viral–bacterial co-infections in the respiratory tract
title_full_unstemmed Viral–bacterial co-infections in the respiratory tract
title_short Viral–bacterial co-infections in the respiratory tract
title_sort viral–bacterial co-infections in the respiratory tract
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7108227/
https://www.ncbi.nlm.nih.gov/pubmed/27940028
http://dx.doi.org/10.1016/j.mib.2016.11.003
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