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Prevalence and clinical characteristics of human CoV-HKU1 in children with acute respiratory tract infections in China

BACKGROUND: Human CoV-HKU1 (HCoV-HKU1) has been isolated from a 71-year-old man with pneumonia; however, the impact and role of emerging HCoV-HKU1 have not been defined in children with acute respiratory tract infection (ARTI). OBJECTIVE: To investigate the Prevalence and clinical characteristics of...

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Autores principales: Jin, Yu, Song, Jing-Rong, Xie, Zhi-Ping, Gao, Han-Chun, Yuan, Xin-Hui, Xu, Zi-Qian, Yan, Kun-Long, Zhao, Yang, Xiao, Ni-Guang, Hou, Yun-De, Duan, Zhao-Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier B.V. 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7108232/
https://www.ncbi.nlm.nih.gov/pubmed/20702134
http://dx.doi.org/10.1016/j.jcv.2010.07.002
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author Jin, Yu
Song, Jing-Rong
Xie, Zhi-Ping
Gao, Han-Chun
Yuan, Xin-Hui
Xu, Zi-Qian
Yan, Kun-Long
Zhao, Yang
Xiao, Ni-Guang
Hou, Yun-De
Duan, Zhao-Jun
author_facet Jin, Yu
Song, Jing-Rong
Xie, Zhi-Ping
Gao, Han-Chun
Yuan, Xin-Hui
Xu, Zi-Qian
Yan, Kun-Long
Zhao, Yang
Xiao, Ni-Guang
Hou, Yun-De
Duan, Zhao-Jun
author_sort Jin, Yu
collection PubMed
description BACKGROUND: Human CoV-HKU1 (HCoV-HKU1) has been isolated from a 71-year-old man with pneumonia; however, the impact and role of emerging HCoV-HKU1 have not been defined in children with acute respiratory tract infection (ARTI). OBJECTIVE: To investigate the Prevalence and clinical characteristics of HCoV-HKU1 in children with ARTI in Lanzhou, China. STUDY DESIGN: The reverse transcription polymerase chain reaction (RT-PCR) or PCR was employed to screen HCoV-HKU1 and other common respiratory viruses in 645 nasopharyngeal aspirate (NPA) specimens collected from children with ARTI from November 2006 to October 2008. All PCR positive products were sequenced. And the demographic and clinical data were collected for all patients. RESULTS: Nineteen of 645 (2.95%) specimens tested positive for HCoV-HKU1, and all HCoV-HKU1 positive specimens were distributed in the winter and spring season. The HCoV-HKU1 co-infection rate with other respiratory viruses was 47.37% (9/19). There was no statistically significant difference in the detection rate between groups by age or gender, except between patients with and without underlying diseases. The phylogenetic analysis indicated that HCoV-HKU1 genotype B was circulating in the years 2007 and 2008 in children with ARTI in Lanzhou, China. CONCLUSIONS: HCoV-HKU1 is an uncommon virus existing among Chinese children with ARTI. Children with underlying diseases are more vulnerable to viral infection. Only HCoV-HKU1 genotype B circulated locally.
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spelling pubmed-71082322020-03-31 Prevalence and clinical characteristics of human CoV-HKU1 in children with acute respiratory tract infections in China Jin, Yu Song, Jing-Rong Xie, Zhi-Ping Gao, Han-Chun Yuan, Xin-Hui Xu, Zi-Qian Yan, Kun-Long Zhao, Yang Xiao, Ni-Guang Hou, Yun-De Duan, Zhao-Jun J Clin Virol Article BACKGROUND: Human CoV-HKU1 (HCoV-HKU1) has been isolated from a 71-year-old man with pneumonia; however, the impact and role of emerging HCoV-HKU1 have not been defined in children with acute respiratory tract infection (ARTI). OBJECTIVE: To investigate the Prevalence and clinical characteristics of HCoV-HKU1 in children with ARTI in Lanzhou, China. STUDY DESIGN: The reverse transcription polymerase chain reaction (RT-PCR) or PCR was employed to screen HCoV-HKU1 and other common respiratory viruses in 645 nasopharyngeal aspirate (NPA) specimens collected from children with ARTI from November 2006 to October 2008. All PCR positive products were sequenced. And the demographic and clinical data were collected for all patients. RESULTS: Nineteen of 645 (2.95%) specimens tested positive for HCoV-HKU1, and all HCoV-HKU1 positive specimens were distributed in the winter and spring season. The HCoV-HKU1 co-infection rate with other respiratory viruses was 47.37% (9/19). There was no statistically significant difference in the detection rate between groups by age or gender, except between patients with and without underlying diseases. The phylogenetic analysis indicated that HCoV-HKU1 genotype B was circulating in the years 2007 and 2008 in children with ARTI in Lanzhou, China. CONCLUSIONS: HCoV-HKU1 is an uncommon virus existing among Chinese children with ARTI. Children with underlying diseases are more vulnerable to viral infection. Only HCoV-HKU1 genotype B circulated locally. Published by Elsevier B.V. 2010-10 2010-08-10 /pmc/articles/PMC7108232/ /pubmed/20702134 http://dx.doi.org/10.1016/j.jcv.2010.07.002 Text en Copyright © 2010 Published by Elsevier B.V. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Jin, Yu
Song, Jing-Rong
Xie, Zhi-Ping
Gao, Han-Chun
Yuan, Xin-Hui
Xu, Zi-Qian
Yan, Kun-Long
Zhao, Yang
Xiao, Ni-Guang
Hou, Yun-De
Duan, Zhao-Jun
Prevalence and clinical characteristics of human CoV-HKU1 in children with acute respiratory tract infections in China
title Prevalence and clinical characteristics of human CoV-HKU1 in children with acute respiratory tract infections in China
title_full Prevalence and clinical characteristics of human CoV-HKU1 in children with acute respiratory tract infections in China
title_fullStr Prevalence and clinical characteristics of human CoV-HKU1 in children with acute respiratory tract infections in China
title_full_unstemmed Prevalence and clinical characteristics of human CoV-HKU1 in children with acute respiratory tract infections in China
title_short Prevalence and clinical characteristics of human CoV-HKU1 in children with acute respiratory tract infections in China
title_sort prevalence and clinical characteristics of human cov-hku1 in children with acute respiratory tract infections in china
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7108232/
https://www.ncbi.nlm.nih.gov/pubmed/20702134
http://dx.doi.org/10.1016/j.jcv.2010.07.002
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