Recent advances in bioinorganic chemistry of bismuth

Bismuth has been used in medicine for over two centuries for the treatment of various diseases, in particular for gastrointestinal disorders, owing to its antimicrobial activity. Recent structural characterization of bismuth drugs provides an insight into assembly and pharmacokinetic pathway of the...

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Detalles Bibliográficos
Autores principales: Li, Hongyan, Sun, Hongzhe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7108238/
https://www.ncbi.nlm.nih.gov/pubmed/22322154
http://dx.doi.org/10.1016/j.cbpa.2012.01.006
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author Li, Hongyan
Sun, Hongzhe
author_facet Li, Hongyan
Sun, Hongzhe
author_sort Li, Hongyan
collection PubMed
description Bismuth has been used in medicine for over two centuries for the treatment of various diseases, in particular for gastrointestinal disorders, owing to its antimicrobial activity. Recent structural characterization of bismuth drugs provides an insight into assembly and pharmacokinetic pathway of the drugs. Mining potential protein targets inside the pathogen via metallomic/metalloproteomic approach and further characterization on the interactions of bismuth drugs with these targets laid foundation in understanding the mechanism of action of bismuth drugs. Such studies would be beneficial in rational design of new potential drugs.
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spelling pubmed-71082382020-03-31 Recent advances in bioinorganic chemistry of bismuth Li, Hongyan Sun, Hongzhe Curr Opin Chem Biol Article Bismuth has been used in medicine for over two centuries for the treatment of various diseases, in particular for gastrointestinal disorders, owing to its antimicrobial activity. Recent structural characterization of bismuth drugs provides an insight into assembly and pharmacokinetic pathway of the drugs. Mining potential protein targets inside the pathogen via metallomic/metalloproteomic approach and further characterization on the interactions of bismuth drugs with these targets laid foundation in understanding the mechanism of action of bismuth drugs. Such studies would be beneficial in rational design of new potential drugs. Elsevier Ltd. 2012-04 2012-02-07 /pmc/articles/PMC7108238/ /pubmed/22322154 http://dx.doi.org/10.1016/j.cbpa.2012.01.006 Text en Copyright © 2012 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Li, Hongyan
Sun, Hongzhe
Recent advances in bioinorganic chemistry of bismuth
title Recent advances in bioinorganic chemistry of bismuth
title_full Recent advances in bioinorganic chemistry of bismuth
title_fullStr Recent advances in bioinorganic chemistry of bismuth
title_full_unstemmed Recent advances in bioinorganic chemistry of bismuth
title_short Recent advances in bioinorganic chemistry of bismuth
title_sort recent advances in bioinorganic chemistry of bismuth
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7108238/
https://www.ncbi.nlm.nih.gov/pubmed/22322154
http://dx.doi.org/10.1016/j.cbpa.2012.01.006
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