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The A–Z of Zika drug discovery
Despite the recent outbreak of Zika virus (ZIKV), there are still no approved treatments, and early-stage compounds are probably many years away from approval. A comprehensive A–Z review of the recent advances in ZIKV drug discovery efforts is presented, highlighting drug repositioning and computati...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier Ltd.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7108251/ https://www.ncbi.nlm.nih.gov/pubmed/29935345 http://dx.doi.org/10.1016/j.drudis.2018.06.014 |
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author | Mottin, Melina Borba, Joyce V.V.B. Braga, Rodolpho C. Torres, Pedro H.M. Martini, Matheus C. Proenca-Modena, Jose Luiz Judice, Carla C. Costa, Fabio T.M. Ekins, Sean Perryman, Alexander L. Horta Andrade, Carolina |
author_facet | Mottin, Melina Borba, Joyce V.V.B. Braga, Rodolpho C. Torres, Pedro H.M. Martini, Matheus C. Proenca-Modena, Jose Luiz Judice, Carla C. Costa, Fabio T.M. Ekins, Sean Perryman, Alexander L. Horta Andrade, Carolina |
author_sort | Mottin, Melina |
collection | PubMed |
description | Despite the recent outbreak of Zika virus (ZIKV), there are still no approved treatments, and early-stage compounds are probably many years away from approval. A comprehensive A–Z review of the recent advances in ZIKV drug discovery efforts is presented, highlighting drug repositioning and computationally guided compounds, including discovered viral and host cell inhibitors. Promising ZIKV molecular targets are also described and discussed, as well as targets belonging to the host cell, as new opportunities for ZIKV drug discovery. All this knowledge is not only crucial to advancing the fight against the Zika virus and other flaviviruses but also helps us prepare for the next emerging virus outbreak to which we will have to respond. |
format | Online Article Text |
id | pubmed-7108251 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Elsevier Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-71082512020-03-31 The A–Z of Zika drug discovery Mottin, Melina Borba, Joyce V.V.B. Braga, Rodolpho C. Torres, Pedro H.M. Martini, Matheus C. Proenca-Modena, Jose Luiz Judice, Carla C. Costa, Fabio T.M. Ekins, Sean Perryman, Alexander L. Horta Andrade, Carolina Drug Discov Today Article Despite the recent outbreak of Zika virus (ZIKV), there are still no approved treatments, and early-stage compounds are probably many years away from approval. A comprehensive A–Z review of the recent advances in ZIKV drug discovery efforts is presented, highlighting drug repositioning and computationally guided compounds, including discovered viral and host cell inhibitors. Promising ZIKV molecular targets are also described and discussed, as well as targets belonging to the host cell, as new opportunities for ZIKV drug discovery. All this knowledge is not only crucial to advancing the fight against the Zika virus and other flaviviruses but also helps us prepare for the next emerging virus outbreak to which we will have to respond. Elsevier Ltd. 2018-11 2018-06-20 /pmc/articles/PMC7108251/ /pubmed/29935345 http://dx.doi.org/10.1016/j.drudis.2018.06.014 Text en © 2018 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Mottin, Melina Borba, Joyce V.V.B. Braga, Rodolpho C. Torres, Pedro H.M. Martini, Matheus C. Proenca-Modena, Jose Luiz Judice, Carla C. Costa, Fabio T.M. Ekins, Sean Perryman, Alexander L. Horta Andrade, Carolina The A–Z of Zika drug discovery |
title | The A–Z of Zika drug discovery |
title_full | The A–Z of Zika drug discovery |
title_fullStr | The A–Z of Zika drug discovery |
title_full_unstemmed | The A–Z of Zika drug discovery |
title_short | The A–Z of Zika drug discovery |
title_sort | a–z of zika drug discovery |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7108251/ https://www.ncbi.nlm.nih.gov/pubmed/29935345 http://dx.doi.org/10.1016/j.drudis.2018.06.014 |
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