Cargando…

The A–Z of Zika drug discovery

Despite the recent outbreak of Zika virus (ZIKV), there are still no approved treatments, and early-stage compounds are probably many years away from approval. A comprehensive A–Z review of the recent advances in ZIKV drug discovery efforts is presented, highlighting drug repositioning and computati...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mottin, Melina, Borba, Joyce V.V.B., Braga, Rodolpho C., Torres, Pedro H.M., Martini, Matheus C., Proenca-Modena, Jose Luiz, Judice, Carla C., Costa, Fabio T.M., Ekins, Sean, Perryman, Alexander L., Horta Andrade, Carolina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier Ltd. 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7108251/ https://www.ncbi.nlm.nih.gov/pubmed/29935345 http://dx.doi.org/10.1016/j.drudis.2018.06.014

Ejemplares similares

OpenZika: An IBM World Community Grid Project to Accelerate Zika Virus Drug Discovery
por: Ekins, Sean, et al.
Publicado: (2016)

Déjà vu: Stimulating open drug discovery for SARS-CoV-2
por: Ekins, Sean, et al.
Publicado: (2020)

Novel computational models offer alternatives to animal testing for assessing eye irritation and corrosion potential of chemicals
por: Silva, Arthur C., et al.
Publicado: (2021)

Natural Compounds as Non-Nucleoside Inhibitors of Zika Virus Polymerase through Integration of In Silico and In Vitro Approaches
por: Ramos, Paulo Ricardo Pimenta da Silva, et al.
Publicado: (2022)

Open drug discovery for the Zika virus
por: Ekins, Sean, et al.
Publicado: (2016)

QSAR-Based Virtual Screening: Advances and Applications in Drug Discovery
por: Neves, Bruno J., et al.
Publicado: (2018)

High Throughput and Computational Repurposing for Neglected Diseases
por: Hernandez, Helen W., et al.
Publicado: (2018)

Characterization of Placental Infection by Zika Virus in Humans: A Review of the Literature
por: Venceslau, Emanuella Meneses, et al.
Publicado: (2020)

Deep Learning-driven research for drug discovery: Tackling Malaria
por: Neves, Bruno J., et al.
Publicado: (2020)

STopTox: An in Silico Alternative to Animal Testing for Acute Systemic and Topical Toxicity
por: Borba, Joyce V.B., et al.
Publicado: (2022)

Computationally-guided drug repurposing enables the discovery of kinase targets and inhibitors as new schistosomicidal agents
por: Giuliani, Sandra, et al.
Publicado: (2018)

Repurposing of Tetracyclines for COVID-19 Neurological and Neuropsychiatric Manifestations: A Valid Option to Control SARS-CoV-2-Associated Neuroinflammation?
por: Chaves Filho, Adriano José Maia, et al.
Publicado: (2021)

Illustrating and homology modeling the proteins of the Zika virus
por: Ekins, Sean, et al.
Publicado: (2016)

Efficient detection of Zika virus RNA in patients’ blood from the 2016 outbreak in Campinas, Brazil
por: Judice, Carla Cristina, et al.
Publicado: (2018)

A diarylamine derived from anthranilic acid inhibits ZIKV replication
por: Silva, Suely, et al.
Publicado: (2019)

Machine Learning Model Analysis and Data Visualization with Small Molecules Tested in a Mouse Model of Mycobacterium tuberculosis Infection (2014–2015)
por: Ekins, Sean, et al.
Publicado: (2016)

A Lipidomics Approach in the Characterization of Zika-Infected Mosquito Cells: Potential Targets for Breaking the Transmission Cycle
por: Melo, Carlos Fernando Odir Rodrigues, et al.
Publicado: (2016)

In Silico Repositioning-Chemogenomics Strategy Identifies New Drugs with Potential Activity against Multiple Life Stages of Schistosoma mansoni
por: Neves, Bruno J., et al.
Publicado: (2015)

CHARMM Force Field Parameterization of Peroxisome Proliferator-Activated Receptor γ Ligands
por: Mottin, Melina, et al.
Publicado: (2016)

Pruned Machine Learning Models to Predict Aqueous Solubility
por: Perryman, Alexander L., et al.
Publicado: (2020)

Aedes mosquitoes and Zika virus infection: an A to Z of emergence?
por: Howard, Colin R
Publicado: (2016)

A to Z of Zika Virus: A Comprehensive Review for Clinicians
por: Arora, Harbir Singh
Publicado: (2020)

Specific Biomarkers Associated With Neurological Complications and Congenital Central Nervous System Abnormalities From Zika Virus–Infected Patients in Brazil
por: Kam, Yiu-Wing, et al.
Publicado: (2017)

QSAR-Based Virtual Screening of Natural Products Database for Identification of Potent Antimalarial Hits
por: Ferreira, Letícia Tiburcio, et al.
Publicado: (2021)

Computational and Experimental Approaches Identify Beta-Blockers as Potential SARS-CoV-2 Spike Inhibitors
por: Puhl, Ana C., et al.
Publicado: (2022)

Implications of Zika virus and congenital Zika syndrome for the number of live births in Brazil
por: Castro, Marcia C., et al.
Publicado: (2018)

Unveiling the Kinomes of Leishmania infantum and L. braziliensis Empowers the Discovery of New Kinase Targets and Antileishmanial Compounds
por: Borba, Joyce V.B., et al.
Publicado: (2019)

Duration of Zika Viremia in Serum
por: Fontaine, Albin, et al.
Publicado: (2018)

Adequate Placental Sampling for the Diagnosis and Characterization of Placental Infection by Zika Virus
por: Venceslau, Emanuella Meneses, et al.
Publicado: (2020)

Developmental Outcomes Among Young Children With Congenital Zika Syndrome in Brazil
por: Wheeler, Anne C., et al.
Publicado: (2020)

QSAR-Driven Design and Discovery of Novel Compounds With Antiplasmodial and Transmission Blocking Activities
por: Lima, Marilia N. N., et al.
Publicado: (2018)

Zika-related microcephaly in experimental models
por: Peron, Jean Pierre Schatzmann, et al.
Publicado: (2016)

Transcriptomics-Guided In Silico Drug Repurposing: Identifying New Candidates with Dual-Stage Antiplasmodial Activity
por: Borba, Joyce V. B., et al.
Publicado: (2023)

Outer Membrane Vesicles from Neisseria Meningitidis (Proteossome) Used for Nanostructured Zika Virus Vaccine Production
por: Martins, Paula, et al.
Publicado: (2018)

Zika Virus Replicons for Drug Discovery
por: Xie, Xuping, et al.
Publicado: (2016)

Blocking Zika virus vertical transmission
por: Mesci, Pinar, et al.
Publicado: (2018)

Zika fever and congenital Zika syndrome: An unexpected emerging arboviral disease
por: Chan, Jasper F.W., et al.
Publicado: (2016)

Collaboration for rare disease drug discovery research
por: Litterman, Nadia K., et al.
Publicado: (2014)

Asymptomatic Prenatal Zika Virus Infection and Congenital Zika Syndrome
por: Paixao, Enny S, et al.
Publicado: (2018)

Chimeric yellow fever 17D-Zika virus (ChimeriVax-Zika) as a live-attenuated Zika virus vaccine
por: Giel-Moloney, Maryann, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_iofk3nf6quajp52ark5hsjr9uk