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The dominance of human coronavirus OC43 and NL63 infections in infants

BACKGROUND: It is unknown to what extent the human coronaviruses (HCoVs) OC43, HKU1, 229E and NL63 infect healthy children. Frequencies of infections are only known for hospitalized children. OBJECTIVES: Comparing infection frequencies in children who have mild infections with frequencies in childre...

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Autores principales: Dijkman, Ronald, Jebbink, Maarten F., Gaunt, Eleanor, Rossen, John W.A., Templeton, Kate E., Kuijpers, Taco W., van der Hoek, Lia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier B.V. 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7108278/
https://www.ncbi.nlm.nih.gov/pubmed/22188723
http://dx.doi.org/10.1016/j.jcv.2011.11.011
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author Dijkman, Ronald
Jebbink, Maarten F.
Gaunt, Eleanor
Rossen, John W.A.
Templeton, Kate E.
Kuijpers, Taco W.
van der Hoek, Lia
author_facet Dijkman, Ronald
Jebbink, Maarten F.
Gaunt, Eleanor
Rossen, John W.A.
Templeton, Kate E.
Kuijpers, Taco W.
van der Hoek, Lia
author_sort Dijkman, Ronald
collection PubMed
description BACKGROUND: It is unknown to what extent the human coronaviruses (HCoVs) OC43, HKU1, 229E and NL63 infect healthy children. Frequencies of infections are only known for hospitalized children. OBJECTIVES: Comparing infection frequencies in children who have mild infections with frequencies in children needing hospital uptake will determine whether infection by one of the four HCoVs leads to more severe disease. In addition, the sequence of seroconversions can reveal whether infection by one HCoV protects from infection by other HCoVs. STUDY DESIGN: Two distinct study groups were monitored: healthy children and children hospitalized due to respiratory infection. HCoV natural infection rates in healthy children were obtained by serology in 25 newborns (followed 0–20 months). The frequencies of severe HCoVs infection was determined by real time RT-PCR among 1471 hospitalized infants (<2-years old) with acute respiratory tract disease. RESULTS: The majority of healthy children seroconverted for HCoV-OC43 (n = 19) and HCoV-NL63 (n = 17), less for HCoV-HKU1 (n = 9) and HCoV-229E (n = 5). Notably, HCoV-HKU1 seroconversion was absent after HCoV-OC43 infection. Also HCoV-229E infection was rarely observed after HCoV-NL63 infection (1 out of 5). In the hospital 207 (14%) out of 1471 children were HCoV positive. Again we observed most infection by HCoV-OC43 (n = 85) and HCoV-NL63 (n = 60), followed by HCoV-HKU1 (n = 47) and HCoV-229E (n = 15). CONCLUSIONS: HCoV-NL63 and HCoV-OC43 infections occur frequently in early childhood, more often than HCoV-HKU1 or HCoV-229E infections. HCoV-OC43 and HCoV-NL63 may elicit immunity that protects from subsequent HCoV-HKU1 and HCoV-229E infection, respectively, which would explain why HCoV-OC43 and HCoV-NL63 are the most frequently infecting HCoVs. There are no indications that infection by one of the HCoVs is more pathogenic than others.
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spelling pubmed-71082782020-03-31 The dominance of human coronavirus OC43 and NL63 infections in infants Dijkman, Ronald Jebbink, Maarten F. Gaunt, Eleanor Rossen, John W.A. Templeton, Kate E. Kuijpers, Taco W. van der Hoek, Lia J Clin Virol Article BACKGROUND: It is unknown to what extent the human coronaviruses (HCoVs) OC43, HKU1, 229E and NL63 infect healthy children. Frequencies of infections are only known for hospitalized children. OBJECTIVES: Comparing infection frequencies in children who have mild infections with frequencies in children needing hospital uptake will determine whether infection by one of the four HCoVs leads to more severe disease. In addition, the sequence of seroconversions can reveal whether infection by one HCoV protects from infection by other HCoVs. STUDY DESIGN: Two distinct study groups were monitored: healthy children and children hospitalized due to respiratory infection. HCoV natural infection rates in healthy children were obtained by serology in 25 newborns (followed 0–20 months). The frequencies of severe HCoVs infection was determined by real time RT-PCR among 1471 hospitalized infants (<2-years old) with acute respiratory tract disease. RESULTS: The majority of healthy children seroconverted for HCoV-OC43 (n = 19) and HCoV-NL63 (n = 17), less for HCoV-HKU1 (n = 9) and HCoV-229E (n = 5). Notably, HCoV-HKU1 seroconversion was absent after HCoV-OC43 infection. Also HCoV-229E infection was rarely observed after HCoV-NL63 infection (1 out of 5). In the hospital 207 (14%) out of 1471 children were HCoV positive. Again we observed most infection by HCoV-OC43 (n = 85) and HCoV-NL63 (n = 60), followed by HCoV-HKU1 (n = 47) and HCoV-229E (n = 15). CONCLUSIONS: HCoV-NL63 and HCoV-OC43 infections occur frequently in early childhood, more often than HCoV-HKU1 or HCoV-229E infections. HCoV-OC43 and HCoV-NL63 may elicit immunity that protects from subsequent HCoV-HKU1 and HCoV-229E infection, respectively, which would explain why HCoV-OC43 and HCoV-NL63 are the most frequently infecting HCoVs. There are no indications that infection by one of the HCoVs is more pathogenic than others. Published by Elsevier B.V. 2012-02 2011-12-19 /pmc/articles/PMC7108278/ /pubmed/22188723 http://dx.doi.org/10.1016/j.jcv.2011.11.011 Text en Crown copyright © 2011 Published by Elsevier B.V. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Dijkman, Ronald
Jebbink, Maarten F.
Gaunt, Eleanor
Rossen, John W.A.
Templeton, Kate E.
Kuijpers, Taco W.
van der Hoek, Lia
The dominance of human coronavirus OC43 and NL63 infections in infants
title The dominance of human coronavirus OC43 and NL63 infections in infants
title_full The dominance of human coronavirus OC43 and NL63 infections in infants
title_fullStr The dominance of human coronavirus OC43 and NL63 infections in infants
title_full_unstemmed The dominance of human coronavirus OC43 and NL63 infections in infants
title_short The dominance of human coronavirus OC43 and NL63 infections in infants
title_sort dominance of human coronavirus oc43 and nl63 infections in infants
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7108278/
https://www.ncbi.nlm.nih.gov/pubmed/22188723
http://dx.doi.org/10.1016/j.jcv.2011.11.011
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