The BAFF/APRIL system: Emerging functions beyond B cell biology and autoimmunity

The BAFF system plays a key role in the development of autoimmunity, especially in systemic lupus erythematosus (SLE). This often leads to the assumption that BAFF is mostly a B cell factor with a specific role in autoimmunity. Focus on BAFF and autoimmunity, driven by pharmaceutical successes with...

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Autores principales: Vincent, Fabien B., Saulep-Easton, Damien, Figgett, William A., Fairfax, Kirsten A., Mackay, Fabienne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7108297/
https://www.ncbi.nlm.nih.gov/pubmed/23684423
http://dx.doi.org/10.1016/j.cytogfr.2013.04.003
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author Vincent, Fabien B.
Saulep-Easton, Damien
Figgett, William A.
Fairfax, Kirsten A.
Mackay, Fabienne
author_facet Vincent, Fabien B.
Saulep-Easton, Damien
Figgett, William A.
Fairfax, Kirsten A.
Mackay, Fabienne
author_sort Vincent, Fabien B.
collection PubMed
description The BAFF system plays a key role in the development of autoimmunity, especially in systemic lupus erythematosus (SLE). This often leads to the assumption that BAFF is mostly a B cell factor with a specific role in autoimmunity. Focus on BAFF and autoimmunity, driven by pharmaceutical successes with the recent approval of a novel targeted therapy Belimumab, has relegated other potential roles of BAFF to the background. Far from being SLE-specific, the BAFF system has a much broader relevance in infection, cancer and allergy. In this review, we provide the latest views on additional roles of the BAFF system in health and diseases, as well as an update on BAFF and autoimmunity, with particular focus on current clinical trials.
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spelling pubmed-71082972020-03-31 The BAFF/APRIL system: Emerging functions beyond B cell biology and autoimmunity Vincent, Fabien B. Saulep-Easton, Damien Figgett, William A. Fairfax, Kirsten A. Mackay, Fabienne Cytokine Growth Factor Rev Article The BAFF system plays a key role in the development of autoimmunity, especially in systemic lupus erythematosus (SLE). This often leads to the assumption that BAFF is mostly a B cell factor with a specific role in autoimmunity. Focus on BAFF and autoimmunity, driven by pharmaceutical successes with the recent approval of a novel targeted therapy Belimumab, has relegated other potential roles of BAFF to the background. Far from being SLE-specific, the BAFF system has a much broader relevance in infection, cancer and allergy. In this review, we provide the latest views on additional roles of the BAFF system in health and diseases, as well as an update on BAFF and autoimmunity, with particular focus on current clinical trials. Elsevier Ltd. 2013-06 2013-05-15 /pmc/articles/PMC7108297/ /pubmed/23684423 http://dx.doi.org/10.1016/j.cytogfr.2013.04.003 Text en Copyright © 2013 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Vincent, Fabien B.
Saulep-Easton, Damien
Figgett, William A.
Fairfax, Kirsten A.
Mackay, Fabienne
The BAFF/APRIL system: Emerging functions beyond B cell biology and autoimmunity
title The BAFF/APRIL system: Emerging functions beyond B cell biology and autoimmunity
title_full The BAFF/APRIL system: Emerging functions beyond B cell biology and autoimmunity
title_fullStr The BAFF/APRIL system: Emerging functions beyond B cell biology and autoimmunity
title_full_unstemmed The BAFF/APRIL system: Emerging functions beyond B cell biology and autoimmunity
title_short The BAFF/APRIL system: Emerging functions beyond B cell biology and autoimmunity
title_sort baff/april system: emerging functions beyond b cell biology and autoimmunity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7108297/
https://www.ncbi.nlm.nih.gov/pubmed/23684423
http://dx.doi.org/10.1016/j.cytogfr.2013.04.003
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