Maintaining the silence: reflections on long-term RNAi

Since the demonstration of RNA interference (RNAi) in mammalian cells, considerable research and financial effort has gone towards implementing RNAi as a viable therapeutic platform. RNAi is, without doubt, the most promising strategy for the treatment of human genetic disorders. Because many of the...

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Detalles Bibliográficos
Autores principales: Raemdonck, Koen, Vandenbroucke, Roosmarijn E., Demeester, Joseph, Sanders, Niek N., De Smedt, Stefaan C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2008
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7108305/
https://www.ncbi.nlm.nih.gov/pubmed/18620073
http://dx.doi.org/10.1016/j.drudis.2008.06.008
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author Raemdonck, Koen
Vandenbroucke, Roosmarijn E.
Demeester, Joseph
Sanders, Niek N.
De Smedt, Stefaan C.
author_facet Raemdonck, Koen
Vandenbroucke, Roosmarijn E.
Demeester, Joseph
Sanders, Niek N.
De Smedt, Stefaan C.
author_sort Raemdonck, Koen
collection PubMed
description Since the demonstration of RNA interference (RNAi) in mammalian cells, considerable research and financial effort has gone towards implementing RNAi as a viable therapeutic platform. RNAi is, without doubt, the most promising strategy for the treatment of human genetic disorders. Because many of the targets proposed for RNAi therapy require chronic treatment, researchers agree that the emphasis must now be placed on the safe and long-term application of RNAi drugs to reap the benefits at last.
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spelling pubmed-71083052020-03-31 Maintaining the silence: reflections on long-term RNAi Raemdonck, Koen Vandenbroucke, Roosmarijn E. Demeester, Joseph Sanders, Niek N. De Smedt, Stefaan C. Drug Discov Today Article Since the demonstration of RNA interference (RNAi) in mammalian cells, considerable research and financial effort has gone towards implementing RNAi as a viable therapeutic platform. RNAi is, without doubt, the most promising strategy for the treatment of human genetic disorders. Because many of the targets proposed for RNAi therapy require chronic treatment, researchers agree that the emphasis must now be placed on the safe and long-term application of RNAi drugs to reap the benefits at last. Elsevier Ltd. 2008-11 2008-08-07 /pmc/articles/PMC7108305/ /pubmed/18620073 http://dx.doi.org/10.1016/j.drudis.2008.06.008 Text en Copyright © 2008 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Raemdonck, Koen
Vandenbroucke, Roosmarijn E.
Demeester, Joseph
Sanders, Niek N.
De Smedt, Stefaan C.
Maintaining the silence: reflections on long-term RNAi
title Maintaining the silence: reflections on long-term RNAi
title_full Maintaining the silence: reflections on long-term RNAi
title_fullStr Maintaining the silence: reflections on long-term RNAi
title_full_unstemmed Maintaining the silence: reflections on long-term RNAi
title_short Maintaining the silence: reflections on long-term RNAi
title_sort maintaining the silence: reflections on long-term rnai
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7108305/
https://www.ncbi.nlm.nih.gov/pubmed/18620073
http://dx.doi.org/10.1016/j.drudis.2008.06.008
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